Permanent Work Disability in Crohn's Disease

Ananthakrishnan, Ashwin N.; Weber, Lydia R.; Knox, Josh F.; Skaros, Susan; Emmons, Jeanne; Lundeen, Sarah J.; Issa, Mazen; Otterson, Mary F.; Binion, David G.

doi:10.1111/j.1572-0241.2007.01561.x

Cited by 90 publications

(76 citation statements)

References 8 publications

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“…Furthermore, females have greater disease-related concerns and worries about being treated differently as a result of their disease (31) and are also more likely to report concerns related to attractiveness and body image (8,28) . Previous studies have shown that HRQOL is significantly impaired by work disability (2,3,17,42) . The work disability rates of IBD patients range between 1.3% and 34% (45) .…”

Section: Discussionmentioning

confidence: 99%

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QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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-Context -Inflammatory bowel disease causes physical and psychosocial consequences that can affect the health related quality of life. Objectives -To analyze the relationship between clinical and sociodemographic factors and quality of life in inflammatory bowel disease patients. Methods -Ninety two patients with Crohn's disease and 58 with ulcerative colitis, filled in the inflammatory bowel disease questionnaire (IBDQ-32) and a questionnaire to collect sociodemographic and clinical data. The association between categorical variables and IBDQ-32 scores was determined using Student t test. Factors statistically significant in the univariate analysis were included in a multivariate regression model. Results -IBDQ-32 scores were significantly lower in female patients (P<0.001), patients with an individual perception of a lower co-workers support (P<0.001) and career fulfillment (P<0.001), patients requiring psychological support (P = 0.010) and pharmacological treatment for anxiety or depression (P = 0.002). A multivariate regression analysis identified as predictors of impaired HRQOL the female gender (P<0.001) and the perception of a lower co-workers support (P = 0.025) and career fulfillment (P = 0.001). Conclusion -The decrease in HRQQL was significantly related with female gender and personal perception of disease impact in success and social relations. These factors deserve a special attention, so timely measures can be implemented to improve the quality of life of patients. HEADINGS -Inflammatory bowel diseases. Crohn disease. Ulcerative colitis. Quality of life. Questionnaires.

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Section: Discussionmentioning

confidence: 99%

“…The work disability rates of IBD patients range between 1.3% and 34% (45) . The frequent flares requiring hospitalization or surgical intervention often leads to sick leave and disability pensions (2,3,4,6,20,44) , which may be the main reason for the decreased career fulfillment in IBD patients.…”

Section: Discussionmentioning

confidence: 99%

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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“…15 We examined the use of concomitant immunosuppressive medications including azathioprine, 6-mercaptopurine, and methotrexate. Disease behavior was characterized according to the Montreal Classification as inflammatory, stricturing, or fistulizing disease.…”

Section: Variablesmentioning

confidence: 99%

“…13,14 In addition to these direct health costs, another important indirect economic consequence of this chronic illness in an economically productive age-group is the cost attributable to lost work productivity and permanent work disability. [15][16][17][18] Hence, measuring the long-term performance of CD drug therapy in routine clinical care needs to emphasize prevention of these CD-related complications. Evaluation of long-term use of infliximab in the routine clinical setting beyond 1 year and its ability to decrease these CD-related complications has been limited to date.…”

mentioning

confidence: 99%

Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohnʼs disease†

Stein

Ananthakrishnan

Issa

et al. 2010

Inflammatory Bowel Diseases

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“…By hand searching, only 9 out of 16 papers published in the English language were found to cover disability in CD. Overall, work is the only dimension of disability that has been widely assessed in IBD [18] . When compared to other disabling diseases, such as multiple sclerosis and rheumatoid arthritis, the consequences of impaired functions (disability) on the management of IBD have been clearly un derestimated.…”

Section: A Need To Develop the First Disability Index For Ibdmentioning

confidence: 99%

What Is the Patient’s Perspective: How Important Are Patient-Reported Outcomes, Quality of Life and Disability?

Peyrin–Biroulet

2010

Dig Dis

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Inflammatory bowel disease (IBD) is known to influence physical, psychological, familial and social dimensions of life. Over the past two decades, attention has been focused on the ability of IBD to alter patients’ quality of life. A number of general and disease-specific scales have been used to assess quality of life in patients with IBD. The Inflammatory Bowel Disease Questionnaire (IBDQ) is the most widely disease-specific tool used in clinical trials. Forty to fifty million individuals in the USA now live with potentially disabling conditions. Disability usually refers to an individual’s inability to perform a task successfully. Disability refers to the problems that are experienced in different areas or health domains, whereas quality of life refers to how the individual feels about these limitations and restrictions. Data about disability are objective descriptions that differ from subjective appraisals such as quality of life, well-being, and personal satisfaction with life. For instance, difficulties in walking (disability) may be in stark contrast to how the individual feels about this difficulty (quality of life). It should be emphasized that the concepts of health-related quality of life and disability are different but not mutually exclusive. When compared to quality of life, disability remains poorly investigated in IBD. Work is the only dimension of disability that has been widely assessed in IBD. Similar to multiple sclerosis and rheumatoid arthritis, developing a specific instrument capable of evaluating disability in IBD is a prerequisite to undertaking clinical trials aimed at identifying therapies capable of changing their clinical course.

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Permanent Work Disability in Crohn's Disease

Cited by 90 publications

References 8 publications

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohnʼs disease†

What Is the Patient’s Perspective: How Important Are Patient-Reported Outcomes, Quality of Life and Disability?

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