Persistence of Colorado Tick Fever Virus in Red Blood Cells

Hughes, Lyndahl E.; Casper, Elizabeth A.; Clifford, Carleton M.

doi:10.4269/ajtmh.1974.23.530

Cited by 46 publications

(12 citation statements)

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“…Mother-to-child transmission was reported in pregnant women (Attoui et al 2005). In children, severe encephalitis and hemorrhages do occur and viremia can be persistent up to 120 days because of virus survival within maturing erythrocytes (Hughes et al 1974). Pericarditis and myocarditis have also been reported (Emmons 1988).…”

Section: Colorado Tick Fevermentioning

confidence: 97%

Rodent-borne diseases and their risks for public health

Meerburg¹,

Singleton²,

Kijlstra³

2009

Critical Reviews in Microbiology

823

722

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Rodents are the most abundant and diversified order of living mammals in the world. Already since the Middle Ages we know that they can contribute to human disease, as black rats were associated with distribution of plague. However, also in modern times rodents form a threat for public health. In this review article a large number of pathogens that are directly or indirectly transmitted by rodents are described. Moreover, a simplified rodent disease model is discussed.

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Section: Colorado Tick Fevermentioning

confidence: 97%

Rodent-borne diseases and their risks for public health

Meerburg¹,

Singleton²,

Kijlstra³

2009

Critical Reviews in Microbiology

823

722

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“…The antigenic variation observed in our study was manifested as one-way differences among strains of CTF virus, although several strains exhibited two-way differences. CTF virus induces viraemias of long duration in human infections, in naturally infected lower animals, and in animals infected experimentally (Bowen et al, 1981a, b;Burgdorfer, 1959;Emmons, 1966;Emmons et al, 1972;Hughes et al, 1974). In addition, CTF virus has been isolated during the viraemic stage in which homologous antibody is present (Emmons et al, 1972;Hughes et al, 1974).…”

mentioning

confidence: 99%

Antigenic Variants of Colorado Tick Fever Virus

Karabatsos

Poland

Emmons

et al. 1987

Journal of General Virology

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SUMMARYTwenty strains of Colorado tick fever (CTF) virus, isolated from ticks, mammals and humans, and two antigenic relatives of CTF virus were compared in crossneutralization tests. Viruses were tested using single-inoculation sera prepared in hamsters. Antigenic variation, as measured by differences detected in the neutralization test, was noted among the virus isolates identified as strains of CTF virus. The virus strains isolated from humans appeared to vary the most in serological reactions. The two antigenic relatives of CTF virus are clearly distinct from strains of CTF and are different from each other. Antigenic relationships between these two viruses were established using two sets of single-inoculation antisera and both complement fixation and neutralization tests. Six distinct antigenic variants of CTF virus isolated from humans and the virus strain from ticks (75V1906) that showed the least antigenic variation, were tested against 49 coded serum pairs from clinically diagnosed cases of CTF. Significant differences were noted in the number of convalescent-phase sera that reacted with each virus strain and in the number of seroconversions observed with each test virus strain. Convalescent phase sera that reacted with multiple virus strains often varied significantly in antibody titre from one virus strain to another. This indicates that, in some instances, antibody was probably produced in response to infection by different antigenic variants of CTF virus.

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“…The remaining steps of the test were carried out as previously described. Ten paired sera obtained from the set of Calisher and others 15 (recovered from American individuals infected by the CTF virus with the following numbers: 2,10,18,21,22,23,26,30,31, and 32) were tested. The acute-stage sera were designated by the letter (a) and were collected between days 0 and 4 after the clinical onset of the disease, and the convalescent sera were designated by the letter (c) and were collected between days 13 and 49 after the clinical onset of the disease.…”

Section: Methodsmentioning

confidence: 99%

Serologic and molecular diagnosis of Colorado tick fever viral infections.

Attoui¹,

Billoir²,

Bruey³

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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Abstract. Molecular and serologic methods usable for the biological diagnosis of Coltivirus infection are reported. We designed a multiplex reverse transcription-polymerase chain reaction system that allowed the simultaneous and specific amplification of three genomic segments from as little as 0.01 plaque-forming units. Another system in the S2 viral segment permitted the differential diagnosis of American and European viral isolates. We also discuss some improvements of previous ELISAs, and the results obtained with paired sera from Colorado tick fever (CTF) virusinfected individuals. Western blot analysis was developed that allowed the detection of antibodies to a 38-kD viral protein in all tested sera. It also enabled the detection of anti-CTF virus antibodies in ELISA-negative sera. Specific IgM antibodies against a synthetic viral peptide could be detected in sera at the acute stage of the infection. Together, these results should permit the diagnosis of Coltivirus infection at any stage of the pathology.Colorado tick fever (CTF) is a severe tick-borne disease that is usually self-limited. This disease occurs in 11 western states in the United States and has also been reported in Canada. 1 Yearly, 200-400 cases are reported throughout the endemic states in the United States. 1,2 The clinical manifestations appear following the bite of the infected adult Rocky Mountain wood tick Dermacentor andersoni 3 and were first reported in the Rocky Mountain region. 1 It has an abrupt onset with flu-like manifestations and some complications of the disease have been reported, particularly in children. [4][5][6][7] Since the first reports in 1875 to reports of Keiffer and Becker in 1906 and 1926, respectively, 8 on a tick bite-generated biphasic fever having clinical symptoms that does not conform to those of Rocky Mountain spotted fever (RMSF), CTF was recognized as being a separate clinical entity from RMSF. Furthermore, the isolation and characterization of the causative agent, CTF virus, by Florio and others 9 in the 1940s established the viral etiology of the disease. In 1990, the genus Coltivirus was created within the family Reoviridae, encompassing those viruses isolated from vertebrates and invertebrates exhibiting a 12-segment double-stranded (ds) RNA genome. At present, this genus includes the CTF virus, the Eyach virus isolated in Germany in 1976, 10 the two Eyach antigenic variants Ar/T577 and Ar/T578 that were isolated in France in 1981 11 , and other members isolated in Indonesia 12 and China. 13The Eyach virus has been suspected to be involved in some neurologic manifestations since antibodies to this virus were detected in sera of patients with polyradiculonevritis. 14 The diagnosis of CTF virus infection is made using various procedures. Isolation and characterization by animal inoculation and neutralization were reported to be the most reliable techniques. 8,15 However, serologic detection by ELI-SA has also been developed. 15 Moreover, many strains were reported 16, 17 that could be detected by RN...

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Persistence of Colorado Tick Fever Virus in Red Blood Cells

Cited by 46 publications

References 0 publications

Rodent-borne diseases and their risks for public health

Rodent-borne diseases and their risks for public health

Antigenic Variants of Colorado Tick Fever Virus

Serologic and molecular diagnosis of Colorado tick fever viral infections.

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