1971
DOI: 10.1111/j.1365-2141.1971.tb02705.x
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Persistent Mixed‐Field Polyagglutination

Abstract: Summary. An example of persistent mixed‐field polyagglutination of the Tn‐type is described, with particular reference to the value of plant seed agglutinins in the elucidation of polyagglutinable states. Extracts of the seeds of Dolichos biflorus, Bauhinia variegata and Wistaria sinensis strongly agglutinate Tn‐polyagglutinable cells. Inhibition studies indicate that N‐acetylgalactosamine may be an important determinant of Tn‐specificity. Positively charged polymers such as polybrene aggregate normal erythro… Show more

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Cited by 84 publications
(41 citation statements)
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“…Tn or T-activated red cells, as well as protease or neuraminidase-treated cells are not agglutinated by Polybrene [7,55,56]. This property has been used [7] to distinguish two cell populations within the same Tn-blood sample : (a) Polyprene-negative cells or true Tn-cells and (b) Polybrene-positive cells or nonTn cells, which are considered to be normal erythrocytes by some investigators [14] but abnormal by others Aggregation scores as in Table 1 [9].…”
Section: Erythrocyte Charge and Polybrene Aggregationmentioning
confidence: 99%
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“…Tn or T-activated red cells, as well as protease or neuraminidase-treated cells are not agglutinated by Polybrene [7,55,56]. This property has been used [7] to distinguish two cell populations within the same Tn-blood sample : (a) Polyprene-negative cells or true Tn-cells and (b) Polybrene-positive cells or nonTn cells, which are considered to be normal erythrocytes by some investigators [14] but abnormal by others Aggregation scores as in Table 1 [9].…”
Section: Erythrocyte Charge and Polybrene Aggregationmentioning
confidence: 99%
“…Since a limited amount of some of the Tn-bloods was available only 5 samples (Da, Go, Tr, Ma and Pi) were separated by the Polybrene procedure as described by Bird et al [7]. All reactions were conducted at 4 "C.…”
Section: Separation Of Tn-positive and Tn-negative Cells Inside A Tn mentioning
confidence: 99%
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“…We therefore concluded that the zeta potential population of peak I and peak II corresponded to the to RBCs and Tn RBCs, respectively. The zeta potential of RBCs reflects the net surface charge of the RBCs, which mainly depends on the sialic acid content of the RBCs surface (Bird et al 1971) and the RBCs with reduced zeta potential exhibit enhanced agglutinability (Myllyla et al 1971). The RBCs from Tn syndrome are deficient of sialic acid, depending on the incompletely synthesized oligosaccharide side chains of the glycophorins of Tn RBCs (Dahr et al 1974), so that the zeta potential of Tn RBCs would reduce rapidly.…”
Section: Discussionmentioning
confidence: 99%
“…The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes (Bird et at., 1971;Vainchenker et al, 1985). This disorder may be associated with a mild hemolytic anemia, leukopenia, or thrombocytopenia, but has also been described in some acute leukemias or myeloproliferative diseases (Bird et al, 1976;Baldwin et al, 1979;Ness et aI., 1979;Vainchenker et al, 1985).…”
Section: Introductionmentioning
confidence: 99%