Personalized medicine: potential impact on the biopharmaceutical industry

Malik, Nadeem A.; Khan, Yasmeen

doi:10.1016/j.drudis.2010.08.019

Cited by 7 publications

(5 citation statements)

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“…Due to the toxic and adverse side effects of synthetic drugs traditional herbal medicine has the potential as a source of new bioactive molecules. [1] In India, Western Ghats is a major biodiversity hotspot along the Western coast covering an area of 159,000 sq km. It is a niche for 4500-15,000 plant species.…”

Section: Introductionmentioning

confidence: 99%

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Sekhar¹,

Ruma²,

Kini³

et al. 2012

Phcog Commn

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Section: Introductionmentioning

confidence: 99%

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Sekhar¹,

Ruma²,

Kini³

et al. 2012

Phcog Commn

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“…In the era of genetically targeted agents, the cost for development of “biological” therapies is fast approaching the $1.2 billion cost per drug for conventional pharmaceutical development (Malik and Khan 2010). At the same time, large pharmaceutical companies have come to view genetically targeted therapy as a two-edged economic sword.…”

Section: The Lessons Of “Personalized Genetics” Relevant To “Personalmentioning

confidence: 99%

“…PARP inhibitors for BRCA mutant tumors) may not meet profitability thresholds set by pharmaceutical companies, or may be marketed for more broadly defined phenotypes where efficacy is more uncertain. While it is true that personalized genomics may improve treatment efficacy and decrease toxicity, a lesson of the genetics era is that the economic hurdles of the biological drug development pipeline remain significant (Malik and Khan 2010). …”

Section: The Lessons Of “Personalized Genetics” Relevant To “Personalmentioning

confidence: 99%

Personalized medicine: new genomics, old lessons

2011

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Personalized medicine uses traditional, as well as emerging concepts of the genetic and environmental basis of disease to individualize prevention, diagnosis and treatment. Personalized genomics plays a vital, but not exclusive role in this evolving model of personalized medicine. The distinctions between genetic and genomic medicine are more quantitative than qualitative. Personalized genomics builds on principles established by the integration of genetics into medical practice. Principles shared by genetic and genomic aspects of medicine, include the use of variants as markers for diagnosis, prognosis, prevention, as well as targets for treatment, the use of clinically validated variants that may not be functionally characterized, the segregation of these variants in non-Mendelian as well as Mendelian patterns, the role of gene–environment interactions, the dependence on evidence for clinical utility, the critical translational role of behavioral science, and common ethical considerations. During the current period of transition from investigation to practice, consumers should be protected from harms of premature translation of research findings, while encouraging the innovative and cost-effective application of those genomic discoveries that improve personalized medical care.

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“…Therefore a detailed study is very much important to authenticate such medicines for proper usage. 3,4 Plant based phytochemicals with known anti-microbial, pathogenic (antibiotic) against human pathogens, anti-bacterial activities. 5,6 Several advanced method are available to confirm the mechanism of action and characterize bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiling by UPLC-PDA-ESI/HDMS and antibacterial activity of Memecylon talbotianum Brandis

Bharathi¹,

Sekhar²,

Kumara³

et al. 2016

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Introduction: UPLC based metabolite profiling was employed to evaluate the chemical constituents of Memecylon talbotianum Brandis extract and its antibacterial activity was studied in vitro. Methods: Methanol extracts of M. talbotianum was subjected to UPLC-PDA-ESI/HDMS metabolite profiling. The antibacterial activity was determined against human pathogens through disc diffusion, Minimum inhibitory concentration (MIC), Minimum biofilm inhibitory concentration (MBIC) test as visualized by Alamar blue and confocal laser scanning microscopy. Results: UPLC-PDA-ESI/HDMS analysis identified eighteen metabolites, synapoyl-hexose-formic acid, kaempferol 3-O-feruloylhexosyl rhamnoside, 6-C-arabinosyl-8-C-glucosylapigenin and isorhamnetin-3-O-glycoside-7-O-glycoside as the main constituents for the first time from this plant. A broad spectrum of antibacterial activity against to test human pathogens (MIC=54 mg/ mL; Gram-positive bacteria) causing lysis at 24 h incubation was reported, resulting in nearly a 4 log 10 CFU / mL drop in cell viability at 1.6 X MIC (Gram-positive) for this extract. The extract at 2 fold MIC inhibited the bacterial biofilm formation and at 8 x MIC eradicated biofilms. However, a higher concentration of this extract was identified in this study for a similar effect on Gram-negative bacteria. Conclusion: The presence of these compounds could contribute to their in vitro inhibitory activities against pathogenic bacterial strains indicating its potential as medicinal agents in treatment and prevention of diseases of bacterial origin. INTRODUCTIONOver the last few decades, research into the traditional medicine system has gained importance in the field of herbal medicines. Traditional medicines are generally viewed as eco-friendly, profitable and comparatively safe due to their age-old usage compared to synthetic therapeutics. Ayurveda, Unani, Siddha and folk medicine are the chief healthcare systems in Indian society. These medicinal systems mainly depend on natural resources. Hence, medicinal plants have immense economic value due to the market for herbal medicine 1,2 However, there are several drawbacks in the growth of herbal medicine, including a lack of proper guidelines and information on medicinal plants, loss of biodiversity, computerization, certification and over-exploitation. Therefore a detailed study is very much important to authenticate such medicines for proper usage.3,4 Plant based phytochemicals with known anti-microbial, pathogenic (antibiotic) against human pathogens, anti-bacterial activities. 5,6 Several advanced method are available to confirm the mechanism of action and characterize bioactive compounds. Coupling of liquid chromatography/mass spectrometry (LC-MS/MS) with atmospheric pressure ionization techniques, i.e., electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), is one of the methods which has been demonstrated to be a powerful tool for the finger printing of total extracts of medicinal plants. These methods favor identification ...

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Personalized medicine: potential impact on the biopharmaceutical industry

Cited by 7 publications

References 0 publications

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Personalized medicine: new genomics, old lessons

Metabolite profiling by UPLC-PDA-ESI/HDMS and antibacterial activity of Memecylon talbotianum Brandis

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