Personalized psychiatry with human iPSCs and neuronal reprogramming

Bardy, Cédric; Greenberg, Zarina; Perry, Seth W.; Licinio, Júlio

doi:10.1016/b978-0-12-813176-3.00012-2

Cited by 8 publications

(4 citation statements)

References 188 publications

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“…Finally, we should point out that recent progress in human-induced pluripotent stem cell (iPSC) technologies provide excellent novel platforms for modeling the genetic mechanisms underlying MDD [118]. These models could be useful especially for studying individual differences and for developing personalized therapies [119]. Furthermore, single-cell models allow the quantitative analysis of synaptic transmission and the plasticity of different cell lines (i.e., GABA-or glutamatergic neurons) and these models are also valuable for compound screening [120].…”

Section: Hippocampal Formationmentioning

confidence: 99%

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Khan

Geiger

Wiborg

et al. 2020

Cells

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Major depressive disorder (MDD) is a severe illness imposing an increasing social and economic burden worldwide. Numerous rodent models have been developed to investigate the pathophysiology of MDD. One of the best characterized and most widely used models is the chronic mild stress (CMS) model which was developed more than 30 years ago by Paul Willner. More than 2000 published studies used this model, mainly to assess novel compounds with potential antidepressant efficacy. Most of these studies examined the behavioral consequences of stress and concomitant drug intervention. Much fewer studies focused on the CMS-induced neurobiological changes. However, the stress-induced cellular and molecular changes are important as they may serve as potential translational biomarkers and increase our understanding of the pathophysiology of MDD. Here, we summarize current knowledge on the structural and molecular alterations in the brain that have been described using the CMS model. We discuss the latest neuroimaging and postmortem histopathological data as well as molecular changes including recent findings on microRNA levels. Different chronic stress paradigms occasionally deliver dissimilar findings, but the available experimental data provide convincing evidence that the CMS model has a high translational value. Future studies examining the neurobiological changes in the CMS model in combination with clinically effective antidepressant drug intervention will likely deliver further valuable information on the pathophysiology of MDD.

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Section: Hippocampal Formationmentioning

confidence: 99%

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Khan

Geiger

Wiborg

et al. 2020

Cells

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“…Patient-derived iPSCs are increasingly popular pre-clinical models of neurological and psychiatric disorders ( Bardy et al., 2020 ; Chailangkarn et al., 2016 ; Israel et al., 2012 ; Mertens et al., 2016 ; Sarkar et al., 2018 ; Tran et al., 2020 ; van den Hurk and Bardy, 2019 ). Two-dimensional monolayer models offer reproducible and relatively high-throughput drug screening capabilities.…”

Section: Discussionmentioning

confidence: 99%

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

et al. 2022

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“…We suggest using brains from animals like nonhuman primates or infertile cattle with an extra X chromosome [ 10 ] or neuronal tissue generated using human induced pluripotent stem cells, preferably from women with TXS and differences in the psychiatric phenotype. The use of human induced pluripotent stem cells harbors the promise of discovering new treatment options for neuropsychiatric disorders [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor

et al. 2022

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Personalized psychiatry with human iPSCs and neuronal reprogramming

Cited by 8 publications

References 188 publications

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor

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