Perspective on oral exfoliative cytology and COVID-19

Mhaske, Shubhangi; Yuwanati, Monal; Mhaske, A. R.; Desai, Ami; Sarode, Sachin C.; Sarode, Gargi S

doi:10.1016/j.oraloncology.2020.104858

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…The results of this study showed that the presence of SARS‐CoV‐2 Spike protein can be demonstrated in desquamated epithelial cells from the dorsum of the tongue, one of the cell‐based disease models for COVID‐19 (Mhaske et al, 2020). It also highlighted that epithelial cells obtained from the dorsum of tongue of COVID‐19 patients show morphological alterations when compared with COVID‐19‐negative patients, although no morphological alterations classically associated with other viral infections were observed, as previously demonstrated (Parada et al, 2021).…”

Section: Discussionmentioning

confidence: 83%

Morphological alterations in tongue epithelial cells infected by SARS‐CoV‐2: A case–control study

et al. 2021

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Objective The aim of the present case–control study was to evaluate the morphological aspects of the epithelial cells from the dorsum of the tongue and the expression of the SARS‐CoV‐2 Spike protein in these cells, in patients with and without COVID‐19 infection. Methods 24 individuals with at least one symptom of COVID‐19 were recruited among inpatients from Hospital Universitário Pedro Ernesto (Rio de Janeiro, Brazil). 14 patients who tested positive for COVID‐19 by RT‐PCR were included in the case group, and 10 patients who tested negative were included in the control group. Cytological smears from the dorsum of the tongue were obtained from all patients and analyzed using immunohistochemistry directed against SARS‐CoV‐2‐Spike protein. Morphological changes in epithelial cells were analyzed using light microscopy. Results Immunohistochemistry showed that 71% of the COVID‐19 patients presented epithelial cells positive for the presence of the SARS‐CoV‐2 Spike protein, and all cells coming from patients in the control group were negative. Cytological analysis showed significant differences when comparing epithelial cells from COVID‐19‐positive and COVID‐19‐negative patients. Conclusion COVID‐19 may generate dimensional changes in tongue epithelial cells; however, further studies are necessary to understand how this happens.

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Section: Discussionmentioning

confidence: 83%

Morphological alterations in tongue epithelial cells infected by SARS‐CoV‐2: A case–control study

et al. 2021

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“…Obviously, the analogic impression is probably more contaminated on the corresponding site of OML because of the many microbes involved in them (opportunistic fungal infections, HSV-1, HSV-2, varicella zoster virus, Coxsackie viruses, HPV) and generally plaque-associated infective agents. Concurrent oral exfoliative cytology and intraoral scanning would be very interesting, easy to use, and advantageous approaches to screening asymptomatic patients and drug therapy efficacy [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

Pros and Cons of CAD/CAM Technology for Infection Prevention in Dental Settings during COVID-19 Outbreak

Barenghi

Garagiola

et al. 2021

Sensors

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The purpose of this commentary is to update the evidence reported in our previous review on the advantages and limitations of computer-aided design/computer-aided manufacturing technology in the promotion of dental business, as well as to guarantee patient and occupational safety. The COVID-19 pandemic led to an unprecedented focus on infection prevention; however, waves of COVID-19 follow one another, asymptomatic cases are nearly impossible to identify by triage in a dental setting, and the effectiveness of long-lasting immune protection through vaccination remains largely unknown. Different national laws and international guidelines (mainly USA-CDC, ECDC) have often brought about dissimilar awareness and operational choices, and in general, there has been very limited attention to this technology. Here, we discuss its advantages and limitations in light of: (a) presence of SARS-CoV-2 in the oral cavity, saliva, and dental biofilm and activation of dormant microbial infections; (b) the prevention of SARS-CoV-2 transmission by aerosol and fomite contamination; (c) the detection of various oral manifestations of COVID-19; (d) specific information for the reprocessing of the scanner tip and the ward from the manufacturers.

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“…Intriguingly, ACE-2 expression has been reported at various sites in the oral cavity and is regarded as one of the potential modes of entry for the virus and its infectivity [3]. Moreover, differential expression of ACE-2 expression in various pathologies prompt researcher to draw many speculative conclusion in pathologies such as oral squamous cell carcinoma (OSCC), oral submucous fibrosis (OSMF), periodontitis, etc [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions

Varadarajan¹,

Balaji²,

Sarode

et al. 2020

Medical Hypotheses

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Perspective on oral exfoliative cytology and COVID-19

Cited by 4 publications

References 8 publications

Morphological alterations in tongue epithelial cells infected by SARS‐CoV‐2: A case–control study

Morphological alterations in tongue epithelial cells infected by SARS‐CoV‐2: A case–control study

Pros and Cons of CAD/CAM Technology for Infection Prevention in Dental Settings during COVID-19 Outbreak

EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions

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