Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

Iljazović, Aida; Roy, Urmi; Galvez, Eric; Lesker, Till Robin; Zhao, Bei; Gronow, Achim; Amend, Lena; Will, Sabine Eva; Hofmann, Julia; Pils, Marina C.; Schmidt‐Hohagen, Kerstin; Neumann‐Schaal, Meina; Strowig, Till

doi:10.1038/s41385-020-0296-4

Cited by 289 publications

(210 citation statements)

References 83 publications

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“…Of the species not initially isolated from humans, P. albensis , P. brevis , P. bryantii and P. ruminicola were all isolated from ruminants; P. pectinovora from pig feces; P. falsenii from the oral cavity of monkeys; and P. paludivivens from plant residue and rice roots [ 62 , 63 ]. Recently, three novel species, P. muris , P. rodentium , and P. intestinalis , were isolated from mouse colonic content [ 64 ]. Interestingly, 16S rRNA gene sequencing results of samples derived from the gut of moths and marine deep sediments have been shown to have 98.8 and 99.3% sequence identity to P. copri and P. tannerae , respectively [ 62 ].…”

Section: Prevotella Within the Gut Microbial Comentioning

confidence: 99%

“…One possible way might be through its association with short chain fatty acid (SCFA)-mediated mucosal immune homeostasis. Prevotella produces acetate as an end product of anaerobic microbial fermentation in the intestine [ 64 , 93 ]. Acetate is utilized by other commensals such as Roseburia and Faecalibacterium to produce butyrate [ 91 ].…”

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

“…In addition, there is a growing body of evidence in humans suggesting a link between the increase in Prevotella spp. at the intestinal mucosal site to localized and systemic disease [ 30 , 64 ]. Iljazovic et al [ 64 ] investigated the potential causal role of P. intestinalis nov. sp.…”

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

“…at the intestinal mucosal site to localized and systemic disease [ 30 , 64 ]. Iljazovic et al [ 64 ] investigated the potential causal role of P. intestinalis nov. sp. strain in intestinal dysbiosis and inflammation.…”

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

“…Colonization with P. intestinalis decreased IL-18 production, which exacerbated colonic inflammation in immunocompetent mice [ 64 ]. Strikingly, when recombinant IL-18 was administered back to these mice, colitis symptoms, including inflammation, were decreased [ 64 ]. This study highlights the need for mechanistic experiments to determine the causal role(s) Prevotella spp.…”

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

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Prevotella in Pigs: The Positive and Negative Associations with Production and Health

et al. 2020

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A diverse and dynamic microbial community (known as microbiota) resides within the pig gastrointestinal tract (GIT). The microbiota contributes to host health and performance by mediating nutrient metabolism, stimulating the immune system, and providing colonization resistance against pathogens. Manipulation of gut microbiota to enhance growth performance and disease resilience in pigs has recently become an active area of research in an era defined by increasing scrutiny of antimicrobial use in swine production. In order to develop microbiota-targeted strategies, or to identify potential next-generation probiotic strains originating from the endogenous members of GIT microbiota in pigs, it is necessary to understand the role of key commensal members in host health. Many, though not all, correlative studies have associated members of the genus Prevotella with positive outcomes in pig production, including growth performance and immune response; therefore, a comprehensive review of the genus in the context of pig production is needed. In the present review, we summarize the current state of knowledge about the genus Prevotella in the intestinal microbial community of pigs, including relevant information from other animal species that provide mechanistic insights, and identify gaps in knowledge that must be addressed before development of Prevotella species as next-generation probiotics can be supported.

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Section: Prevotella Within the Gut Microbial Comentioning

confidence: 99%

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

Section: Prevotella and The Intestinal Immune Smentioning

confidence: 99%

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Prevotella in Pigs: The Positive and Negative Associations with Production and Health

et al. 2020

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The relationship between pinworm (Trypanoxyuris) infection and gut bacteria in wild black howler monkeys (Alouatta pigra)

Martínez-Mota

Righini

Mallott

et al. 2021

American J Primatol

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Gut bacteria may coexist with other groups of organisms, such as nematode parasites, that inhabit the gastrointestinal tract of primates; however, the possible effects of endoparasites on bacterial communities are frequently overlooked. Here we explored whether infection with Trypanoxyuris, an oxyurid gastrointestinal parasite, is associated with changes in the gut bacterial community of wild black howler monkeys (Alouatta pigra), by comparing gut bacterial communities of consistently infected individuals and individuals that never tested positive for Trypanoxyuris throughout different months across the year. We additionally controlled for other sources of variation reported to influence the primate microbiome including individual identity, social group, and seasonality. Trypanoxyuris infection was not related to differences in gut bacterial alpha diversity, but was weakly associated with differences in gut bacterial community structure. In contrast, among the covariates considered, both individual identity and social group were more strongly associated with variation in the howler gut bacterial community. Our results suggest that gastrointestinal parasites may be associated, to some extent, with shifts in the gut bacterial communities hosted by free-ranging primates, although a causal link still needs to be established. Further studies of wild primate hosts infected with parasite species with different pathogenicity are needed to better elucidate health-related consequences from the parasite-microbiome interplay.

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Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

2022

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Background: About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obesity has several long-lasting adverse health effects on the offspring, including increasing offspring's breast cancer risk and mortality. Gut microbiota is a player in obesity as well as may impact breast carcinogenesis. Gut microbiota is established early in life and the microbial composition of an infant's gut becomes permanently dysregulated because of maternal obesity. Metabolites from the microbiota, especially short chain fatty acids (SCFAs), play a critical role in mediating the effect of gut bacteria on multiple biological functions, such as immune system, including tumor immune responses.Recent Findings: Maternal obesity can pre-program daughter's breast cancer to be more aggressive, less responsive to treatments and consequently more likely to cause breast cancer related death. Maternal obesity may also induce poor response to immune checkpoint inhibitor (ICB) therapy through increased abundance of inflammation associated microbiome and decreased abundance of bacteria that are linked to production of SCFAs. Dietary interventions that increase the abundance of bacteria producing SCFAs potentially reverses offspring's resistance to breast cancer therapy. Conclusion:Since immunotherapies have emerged as highly effective treatments for many cancers, albeit there is an urgent need to enlarge the patient population who will be responsive to these treatments. One of the factors which may cause ICB refractoriness could be maternal obesity, based on its effects on the microbiota markers of ICB therapy response among the offspring. Since about 40% of children are born to obese mothers in the Western societies, it is important to determine if maternal obesity impairs offspring's response to cancer immunotherapies.

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Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

Cited by 289 publications

References 83 publications

Prevotella in Pigs: The Positive and Negative Associations with Production and Health

Prevotella in Pigs: The Positive and Negative Associations with Production and Health

The relationship between pinworm (Trypanoxyuris) infection and gut bacteria in wild black howler monkeys (Alouatta pigra)

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

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