Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment

Lian-kui, Wen; Miao, X. Y.; Di, Jia; Tong, Xin; Wang, Yuzhu; He, Ya‐Ling; Zheng, Fei

doi:10.3389/fnut.2023.1113099

Cited by 9 publications

(3 citation statements)

References 136 publications

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“…Malathion exposure has the potential to disrupt this delicate balance, possibly escalating the aberrant changes associated with tauopathies such as AD. [ 155 ] In another experimental study by Moyano et al showed that exposure to the CP at a dose of 30 μM boosted GSK‐3β expression and activity in septal SN56 basal forebrain cholinergic neurons. This elevated GSK‐3β activity resulted in an increase in the phosphorylation of the tau protein.…”

Section: Effect Of Opps On Glial Cellsmentioning

confidence: 99%

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

Yadav,

Kaur,

Yadav

et al. 2024

J Biochem & Molecular Tox

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The most widespread neurodegenerative disorder, Alzheimer's disease (AD) is marked by severe behavioral abnormalities, cognitive and functional impairments. It is inextricably linked with the deposition of amyloid β (Aβ) plaques and tau protein in the brain. Loss of white matter, neurons, synapses, and reactive microgliosis are also frequently observed in patients of AD. Although the causative mechanisms behind the neuropathological alterations in AD are not fully understood, they are likely influenced by hereditary and environmental factors. The etiology and pathogenesis of AD are significantly influenced by the cells of the central nervous system, namely, glial cells and neurons, which are directly engaged in the transmission of electrical signals and the processing of information. Emerging evidence suggests that exposure to organophosphate pesticides (OPPs) can trigger inflammatory responses in glial cells, leading to various cascades of events that contribute to neuroinflammation, neuronal damage, and ultimately, AD pathogenesis. Furthermore, there are striking similarities between the biomarkers associated with AD and OPPs, including neuroinflammation, oxidative stress, dysregulation of microRNA, and accumulation of toxic protein aggregates, such as amyloid β. These shared markers suggest a potential mechanistic link between OPP exposure and AD pathology. In this review, we attempt to address the role of OPPs on altered cell physiology of the brain cells leading to neuroinflammation, mitochondrial dysfunction, and oxidative stress linked with AD pathogenesis.

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Section: Effect Of Opps On Glial Cellsmentioning

confidence: 99%

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

Yadav,

Kaur,

Yadav

et al. 2024

J Biochem & Molecular Tox

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“…Insecticides, including organophosphates and pyrethroids, act by binding to specific receptors in the central nervous system, primarily acetylcholinesterase . According to recent studies, prolonged exposure to these chemicals can disrupt normal levels of monoamines. − This may increase the risk of neurological and developmental disorders. ,− …”

Section: Introductionmentioning

confidence: 99%

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

Kumar,

Sinha,

Gouda

2024

J. Am. Soc. Mass Spectrom.

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For the simultaneous determination of monoamine neurotransmitters (NTs) like dopamine, serotonin, noradrenaline, and epinephrine, and their metabolites (metanephrine, normetanephrine, 3-methoxytyramine, vanillylmandelic acid, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindoleacetic acid), a robust liquid chromatography method coupled with tandem mass spectrometry (LC–MS/MS) was introduced as the analytical method. This analytical method proved to be accurate for the simultaneous measurement of the amounts of 11 NTs and their metabolites in biological samples. The method proved to be more efficient and better than the previously reported method in terms of precision, recovery, sample requirement, and extraction procedure. The reported method requires only 100 μL of blood and 200 μL of urine, and the extraction procedure requires acetonitrile precipitation, filtration, drying, and reconstitution in water. The separation of all analytes was performed on an C18 column (4.6 mm × 150 mm and 1.8 μm). A 10 min gradient elution program with a mobile phase consisting of phase A (0.2% formic acid in water) and phase B (methanol) was used. The positive ionization mode was used for the detection of all analytes in multiple reaction monitoring (MRM). The proposed method was validated with an internal standard and yielded lower limits of detection and quantification ranges of 0.0182–0.0797 ng/mL and 0.0553–0.2415 ng/mL, respectively, with a good linearity (R 2) between 0.9959 and 0.9994. The recoveries ranged from 73.37% to 116.63% in blood and from 80.9% to 115.33% in urine. For the NTs and metabolites, the intra- and interday % CV were 0.24–9.36 and 0.85–9.67, respectively. The developed LC–MS/MS method was successfully used for the determination of trace amounts of endogenous compounds in human blood and urine samples.

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“…In above 65 years aged population is 11.7% and 10.8% of patients between 45-64 years of age [3]. Environmental pollutants i.e., pesticides are one of the risk factors for the development of cognitive impairment [4]. Current experimental evidence also revealed that the herbicide also causes cognitive dysfunction in rats via synaptic impairment and hippocampal neuron damage [5].…”

Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

Muthuraman

2023

BJSTR

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Rutin is a bioflavonoid and plant pigment. It is found in various fruits and vegetables. Chemically, it is known as rutoside, quercetin-3-O-rutinoside, sophorin, and vitamin P. It has antioxidant, anti-inflammatory, and immunomodulation-associated neuroprotective and anti-Alzheimer actions. The role of rutin against glyphosate-induced cognitive dysfunction in adult zebrafish has not been studied yet. The present study focused on the role of rutin on glyphosate-induced cognitive dysfunction in adult zebrafish. The glyphosate (GYP, 0.5 mg/L), rutin (50, 100, and 150 µg/L), and donepezil (DP, 1 µg/mL) for 30 minutes/day were exposed for 14 consecutive days. On the 14th day, the neurobehavioural changes were assessed by three horizontal compartment test, optokinetic motor response (OMR), startle response (SR), and T-maze tests. On the 15th day, animals were sacrificed and brain biomarker changes i.e., brain acetylcholinesterase (AChE) activity, thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) levels were estimated. The exposure to rutin ameliorated the GYP-induced cognitive dysfunctions and changes in tissue biomarkers. The results are similar to DP-exposed animals. Hence, rutin can be useful for the treatment of herbicide toxicity like GYP-associated neurocognitive disorders viz anti-oxidant, anti-lipid peroxidation, and modulatory action of cholinergic neurotransmitter activities.

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Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment

Cited by 9 publications

References 136 publications

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

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