Peut-on prévenir ou guérir les cancers d’origine infectieuse ?

Gisserot, O.; Romeo, Elisabetta L.; Boudin, Laurys; Tsogou, P. Tsitsi Nding; Abed, Soumeya; Bladé, J; Jauréguiberry, J.P. de

doi:10.1016/j.revmed.2013.11.014

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Epidemiological reports have founded several well-defined potential factors for the growth and development of cancer such as heredity, age, use of tobacco, diet, inflammation, and chronic infections with pathogens. Infection is the cause for approximately 16% of all malignancies worldwide [ 19 ]. A number of bacteria have shown the capacity to alter many pathways and molecules of host cells for their intracellular survival in the host.…”

Section: Discussionmentioning

confidence: 99%

Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

et al. 2016

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Accumulating evidence has recently supported the association of bacterial infection with the growth and development of cancers, particularly in organs that are constantly exposed to bacteria such as the lungs, colon, cervical cancer etc. Our in silico study on the proteome of Chlamydia pneumoniae suggests an unprecedented idea of the etiology of lung cancer and have revealed that the infection of C. pneumoniae is associated with lung cancer development and growth. It is reasonable to assume that C. pneumoniae transports its proteins within host-intracellular organelles during infection, where they may work with host-cell proteome. The current study was performed for the prediction of nuclear targeting protein of C. pneumoniae in the host cell using bioinformatics predictors including ExPASy pI/Mw tool, nuclear localization signal (NLS) mapper, balanced sub cellular localization predictor (BaCeILo), and Hum-mPLoc 2.0. We predicted 47/1112 nuclear-targeting proteins of C. pneumoniae connected with several possible alterations in host replication and transcription during intracellular infection. These nuclear-targeting proteins may direct to competitive interactions of host and C. pneumoniae proteins with the availability of same substrate and may be involved as etiological agents in the growth and development of lung cancer. These novel findings are expected to access in better understanding of lung cancer etiology and identifying molecular targets for therapy.

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Section: Discussionmentioning

confidence: 99%

Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

et al. 2016

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“…Various studies have revealed the different possible factors involved in the development of cancer, including genetic factors, gender, age, diet, consumption of tobacco, inflammation, and infections by various pathogens. Infection is considered a leading factor involved in the development of about 16% of cancers [33]. It has confirmed that various specific bacterial strains have the ability to alter numerous pathways and molecular events in the host cell for their own survival and involved in the growth and development of different types of cancer [10,32,34].…”

Section: Discussionmentioning

confidence: 99%