pH dependent synthesis of two zinc(II) compounds derived from 5-aminotetrazole-1-isopropanoic acid for treatment of cancer cells

Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells

“…In previous studies, we have reported a series of tetrazole carboxylate–based complexes as nanoboosters, which can boost O 2 or H 2 O 2 to generate ROS to induce cancer cell apoptosis, exhibiting high toxicity and excellent biocompatibility for photodynamic therapy ( Yang G et al, 2018 ; Zhai et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2019 ; Xu et al, 2020 ; Yang et al, 2020 ). As an extension of our research, the tetrazole carboxylic acid ligand–based H 4 L ( Scheme 1 ) was selected for self-assembly with Gd(III)–Cu(II) ions, and a new heteronuclear complex [Gd 2 Cu(L) 2 (H 2 O) 10 ]·6H 2 O was obtained with good antitumor properties ( Scheme 1 ).…”

Synthesis, Characterization and Bioactivity of Three Tetrazole Carboxylate Based Co(II) Complexes

“…As a multifunctional material, coordination complexes have been widely prepared and actively used in the treatment of cancer, and the complexes based on tetrazole‐carboxylate have shown a good inhibitory effect on tumor cell proliferation in the application of anticancer. In a previous study, a series of tetrazole‐carboxylate‐based mononuclear ruthenium(II) complexes were synthesized, which exhibited low dark toxicity, high excited‐state reactivity and excellent biocompatibility when used in photodynamic therapy, and Cu(II), Sm(III), Ca(II) complexes based on these ligands also have low IC 50 values against cancer cells [20–25] . In this study, we focus on Co(II) complexes based on H 3 tzpha, Hpztzma and Hpytza (Scheme 1).…”

“…In a previous study, a series of tetrazole-carboxylate-based mononuclear ruthenium(II) complexes were synthesized, which exhibited low dark toxicity, high excited-state reactivity and excellent biocompatibility when used in photodynamic therapy, and Cu(II), Sm(III), Ca(II) complexes based on these ligands also have low IC 50 values against cancer cells. [20][21][22][23][24][25] In this study, we focus on Co(II) complexes based on H 3 tzpha, Hpztzma and Hpytza (Scheme 1). As a result, three complexes [Co 3 (tzpha) 2 (4,4'bipy) 3…”

Bifunctional tetrazole–carboxylate ligand based Zn(ii) complexes: synthesis and their excellent potential anticancer properties

“…From the Table 1, the IC 50 of the complexes 1 and 2 were superior to the other complexes with Zn( ii ) based complexes, and also other complexes based on tetrazole–carboxylate. 35,42–44 Although the role of Zn( ii ) in the regulation of apoptosis seems to be cell type specific, and most studies are focused on the inhibitory effect of on the proliferation of breast and prostate cancer cells. 39,40 Our results showed that Zn( ii ) complexes also have obvious inhibitory cytotoxicity on HeLa cells, which plays an important role in mediating drug resistance and stress-induced apoptosis inhibition in tumoral cells.…”