pH responsive graft copolymers of chitosan

Yilmaz, Elvan; Yalinca, Zulal; Yahya, Kovan; Sirotina, Uliana

doi:10.1016/j.ijbiomac.2015.10.003

Cited by 18 publications

(8 citation statements)

References 31 publications

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“…The pH-responsive nanoparticles can release drugs rapidly in the tumor site and slowly or even not at all in the peripheral circulation [28,29,30]. The pH-responsive release of nanoparticles was investigated by two different buffer solutions (pH = 5.5 and pH = 7.4) in vitro.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery

2019

Polymers

251

136

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Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) are well recognized as an ideal drug delivery carrier for their biocompatibility and biodegradability. In order to overcome the disadvantage of drug burst release, chitosan (CS) was used to modify the PLGA nanoparticles. In this work, CS-PLGA nanoparticles with different ratio of CS to PLGA were prepared using high-gravity rotating packed bed (RPB). With the increase of amount of CS, the particle size increased from 132.8 ± 1.5 nm to 172.7 ± 3.2 nm, zeta potential increased from −20.8 ± 1.1 mV to 25.6 ± 0.6 mV, and drug encapsulation efficiency increased from 65.8% to 87.1%. The initial burst release of PLGA NPs reduced after being modified by CS, and the cumulative release was 66.9%, 41.9%, 23.8%, and 14.3%, after 2 h, respectively. The drug release of CS-modified PLGA NPs was faster at pH5.5 than that at pH 7.4. The cellular uptake of CS-modified PLGA NPs increased compared with PLGA NPs, while cell viability was reduced. In conclusion, these results indicated that CS-modified, PTX-loaded PLGA NPs have the advantages of sustained drug release and enhanced drug toxicity, suggesting that CS-modified NPs can be used as carriers of anticancer drugs.

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Section: Resultsmentioning

confidence: 99%

Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery

2019

Polymers

251

136

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“…It should be noted that Table 1 is focused on summarizing synthetic organic monomer subunits. There is also a range of literature focused on naturally occurring materials that have been modified to include charged functional groups, like chitosan [7,8].…”

Section: General Polyampholyte Characteristicsmentioning

confidence: 99%

“…At the same time, much of the recent work in polyampholyte mediated drug delivery takes advantage of the pH responsive behavior of polyampholyte systems. For example, chitosan based polyampholytes have recently been shown to have potential in protein delivery applications, as they have exhibited the ability to adsorb and desorb bovine serum albumin (BSA) in a pH dependent manner [7,8]. However, a combination of design characteristics is required to optimize drug delivery that include biocompatibility, multifunctionality, and responsiveness to the microenvironment.…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Polyampholyte Hydrogels in Biomedical Applications

Haag

Bernards

2017

Gels

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Polyampholytes are a class of polymers made up of positively and negatively charged monomer subunits. Polyampholytes offer a unique tunable set of properties driven by the interactions between the charged monomer subunits. Some tunable properties of polyampholytes include mechanical properties, nonfouling characteristics, swelling due to changes in pH or salt concentration, and drug delivery capability. These characteristics lend themselves to multiple biomedical applications, and this review paper will summarize applications of polyampholyte polymers demonstrated over the last five years in tissue engineering, cryopreservation and drug delivery.

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“…A large number of biopolymers have been grafted with monomers to create pH‐sensitive hydrogel matrices . However, the choice of biopolymer as base matrix has a significant impact in terms of its physical characteristics and its impact on the grafting process.…”

Section: Introductionmentioning

confidence: 99%

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

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Graft polymerization of itaconic acid on tragacanth gum (TG) was carried out using potassium persulfate as initiator to develop smart hydrogels for drug delivery systems. The effect of the grafting parameters on the degree of grafting was investigated. The grafting was significantly influenced by the reaction medium, the reaction temperature and the monomer concentration. The monomer dependency of the system was found to be 1.52. The hydrogels were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and X‐ray diffraction. The grafted TG had an amorphous nature and exhibited excellent swelling in water and strong dependence on the pH of the medium. The grafted TG showed pH‐dependent release of ciprofloxacin which offers the possibility of using these materials in colon‐specific drug targeting for human healthcare systems. © 2018 Society of Chemical Industry

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pH responsive graft copolymers of chitosan

Cited by 18 publications

References 31 publications

Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery

Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery

Polyampholyte Hydrogels in Biomedical Applications

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

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