pH-responsive materials for optical monitoring of wound status

Gamerith, Clemens; Luschnig, Daniel; Ortner, Andreas; Pietrzik, Nikolas; Guse, Jan; Burnet, Michael; Haalboom, Marieke; Palen, Job van der; Heinzle, Andrea; Sigl, Eva; Gübitz, Georg

doi:10.1016/j.snb.2019.126966

Cited by 39 publications

(23 citation statements)

References 47 publications

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“…However, this study did not incorporate wearable devices. Gamerith et al [ 148 ] presented a pH-responsive indicator that changes from yellow to green to blue with rising pH. They demonstrated sensing swabs that could simultaneously be used for wound cleansing and pH sensing, thereby providing important information about the wound status.…”

Section: Key Wound Marker Detectionmentioning

confidence: 99%

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

Sun

Zhang

et al. 2021

Biosensors

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Chronic wounds that are difficult to heal can cause persistent physical pain and significant medical costs for millions of patients each year. However, traditional wound care methods based on passive bandages cannot accurately assess the wound and may cause secondary damage during frequent replacement. With advances in materials science and smart sensing technology, flexible wearable sensors for wound condition assessment have been developed that can accurately detect physiological markers in wounds and provide the necessary information for treatment decisions. The sensors can implement the sensing of biochemical markers and physical parameters that can reflect the infection and healing process of the wound, as well as transmit vital physiological information to the mobile device through optical or electrical signals. Most reviews focused on the applicability of flexible composites in the wound environment or drug delivery devices. This paper summarizes typical biochemical markers and physical parameters in wounds and their physiological significance, reviews recent advances in flexible wearable sensors for wound detection based on optical and electrical sensing principles in the last 5 years, and discusses the challenges faced and future development. This paper provides a comprehensive overview for researchers in the development of flexible wearable sensors for wound detection.

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Section: Key Wound Marker Detectionmentioning

confidence: 99%

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

Sun

Zhang

et al. 2021

Biosensors

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“…The lower pH within an infected site may be used for real-time monitoring of the infection status of wounds because early detection of incipient infections is a crucial step of wound treatment. 271 Bacterial infections create an acidic microenvironment (pH ≤ 6.0) that can trigger the release of antimicrobial therapeutics. 272,273 The efficacy of antimicrobial therapy may be improved by means of targeted delivery.…”

Section: Multidimensional Applications Inmentioning

confidence: 99%

“…This property is utilized for detection and delivery of drug based on pH-sensitivity. The lower pH within an infected site may be used for real-time monitoring of the infection status of wounds because early detection of incipient infections is a crucial step of wound treatment . Bacterial infections create an acidic microenvironment (pH ≤ 6.0) that can trigger the release of antimicrobial therapeutics. , …”

Section: Multidimensional Applications In Regenerative Medicinementioning

confidence: 99%

Biofabricated Nanostructures and Their Composites in Regenerative Medicine

Makvandi

Ghomi

Padil

et al. 2020

ACS Appl. Nano Mater.

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Biosynthesis of nanomaterials is gaining attention as a sustainable, environmentally friendly, and reliable method for manufacturing a extensive array of nanostructures, such as metal/metal oxides and organic and hybrid materials. Green synthesis is considered a crucial tool to reduce the harsh effects associated with conventional synthesis. Nanocomposite materials containing biosynthesized nanostructures are highly sought after in regenerative medicine. In the present Review, biosynthesis of metal/metal oxides and carbon-based nanomaterials using microorganisms (e.g., bacteria and fungi) and natural compounds (e.g., polysaccharides, proteins, fruit juices, and plant extracts) is highlighted. The toxicity of biosynthesized nanoparticles for biomedical application is also reviewed in depth. The applications of bionanocomposites prepared from these ecofriendly nanoparticles in tissue engineering are reviewed to provide readers with a background for future studies.

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“…Some MSAs, based on flexible wearable electronics, for in situ measurement of wound pH, uric acid, temperature, and/or moisture were reported [ 169 , 176 , 177 , 178 , 179 , 180 , 181 ]; unfortunately, no natural compounds were suggested as bioreceptors in such MSAs. In several studies, discussed below, natural compounds were used as the base of a MSA.…”

Section: Application Of Msss and Msasmentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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pH-responsive materials for optical monitoring of wound status

Cited by 39 publications

References 47 publications

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

Biofabricated Nanostructures and Their Composites in Regenerative Medicine

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

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