pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Han, Kai; Zhang, Weiyun; Zhang, Jin; Han, Heyou

doi:10.1002/adhm.201700470

Cited by 41 publications

(22 citation statements)

References 45 publications

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“…When DOX was encapsulated in nanocarriers, its self-fluorescence was quenched because of a concentrated DOX aggregates in local microenvironment. The similar results were also obtained in these publications [26,27].…”

Section: Drug Crystal Property Inside Curdox-npssupporting

confidence: 90%

pH-sensitive polymeric nanoparticles of mPEG-PLGA-PGlu with hybrid core for simultaneous encapsulation of curcumin and doxorubicin to kill the heterogeneous tumour cells in breast cancer

Yuan

ZhuGe

Tong

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107.5 nm and zeta potential of -13.7 mV, determined by DLS. Drug-loading efficiency for curcumin and doxorubicin was reaching to 80.30% and 96.2%, respectively. Moreover, a cascade sustained-release profiles with the faster release of CUR followed by a slower release of DOX was observed in normal pH7.4 condition. Moreover, a pH-sensitive release profile for each cargo was seen in pH5.0 condition. The anti-tumour effect of CURDOX-NPs on CSCs-enriching MCF-7/ADR mammospheres was confirmed by in vitro. Moreover, a significant regression of tumour growth after treatment with CURDOX-NPs was also observed in Xenograft mice model. The percentage of CSCs in tumour significantly decreased from 39.9% in control group to 6.82% after treatment with CURDOX-NPs. The combinational delivery of CUR and DOX may a potentially useful therapeutic strategy for refractory breast cancer.

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Section: Drug Crystal Property Inside Curdox-npssupporting

confidence: 90%

pH-sensitive polymeric nanoparticles of mPEG-PLGA-PGlu with hybrid core for simultaneous encapsulation of curcumin and doxorubicin to kill the heterogeneous tumour cells in breast cancer

Yuan

ZhuGe

Tong

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Additionally, in the last decade, an extensive study concerning the use of active metals such as ruthenium [45], copper [32,46], zinc, cobalt [47,48], or indium-based compounds [49] has received intensive attention as an alternative to cisplatin in order to reduce its cytotoxic effect and increase anticancer properties. The formed coordination bonds have adequate pH-response ability and can release drug molecules under small pH variations [50][51][52][53][54].…”

Section: Design Of Ncps Nano-formulationsmentioning

confidence: 99%

Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

Novio

2020

Molecules

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Conventional cancer chemotherapy presents notable drug side effects due to non-selective action of the chemotherapeutics to normal cells. Nanoparticles decorated with receptor-specific ligands on the surface have shown an important role in improving site-selective binding, retention, and drug delivery to the cancer cells. This review summarizes the recent reported achievements using nanostructured coordination polymers (NCPs) with active targeting properties for cancer treatment in vitro and in vivo. Despite the controversy surrounding the effectivity of active targeting nanoparticles, several studies suggest that active targeting nanoparticles notably increase the selectivity and the cytotoxic effect in tumoral cells over the conventional anticancer drugs and non-targeted nanoparticle platform, which enhances drug efficacy and safety. In most cases, the nanocarriers have been endowed with remarkable capabilities such as stimuli-responsive properties, targeting abilities, or the possibility to be monitored by imaging techniques. Unfortunately, the lack of preclinical studies impedes the evaluation of these unique and promising findings for the translation of NCPs into clinical trials.

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“…Further, coordination polymers comprising organic ligands and metal ions can also be used for efficient monitoring of drug release in tumors. Fe 3+ and polyphenol gallic acid can form a polygonal nanoscale coordination polymer with extremely high Dox loading efficacy (up to 48.3%) in aqueous solution, which exhibits potent antitumor effect [62]. In vitro studies demonstrated that the Dox fluorescence was efficiently quenched once loaded on the coordination polymer.…”

Section: Macromolecule-based Drug Release Monitoringmentioning

confidence: 99%

Recent advances in drug release monitoring

et al. 2019

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Monitoring drug release in vitro and in vivo is of paramount importance to accurately locate diseased tissues, avoid inappropriate drug dosage, and improve therapeutic efficiency. In this regard, it is promising to develop strategies for real-time monitoring of drug release inside targeted cells or even in living bodies. Thus far, many multi-functional drug delivery systems constructed by a variety of building blocks, such as organic molecules, polymeric nanoparticles, micelles, and inorganic nanoparticles, have been developed for drug release monitoring. Especially, with the advancements in imaging modalities relating to nanomaterials, there has been an increasing focus on the use of non-invasive imaging techniques for monitoring drug release and drug efficacy in recent years. In this review, we introduce the application of fluorescence imaging, magnetic resonance imaging (MRI), surface-enhanced Raman scattering (SERS), and multi-mode imaging in monitoring drug release, involving a variety of nanomaterials such as organic or inorganic nanoparticles as imaging agents; their design principles are also elaborated. Among these, a special emphasis is placed on fluorescence-based drug release monitoring strategies, followed by a brief overview of MRI, SERS, and multi-mode imaging-based strategies. In the end, the challenges and prospects of drug release monitoring are also discussed.

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pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Cited by 41 publications

References 45 publications

pH-sensitive polymeric nanoparticles of mPEG-PLGA-PGlu with hybrid core for simultaneous encapsulation of curcumin and doxorubicin to kill the heterogeneous tumour cells in breast cancer

pH-sensitive polymeric nanoparticles of mPEG-PLGA-PGlu with hybrid core for simultaneous encapsulation of curcumin and doxorubicin to kill the heterogeneous tumour cells in breast cancer

Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

Recent advances in drug release monitoring

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