pH‐Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer

He, Xinyu; Yu, Haijun; Bao, Xiaoyue; Cao, Haiqiang; Yin, Qi; Zhang, Zhiwen; Li, Yaping

doi:10.1002/adhm.201500626

Cited by 34 publications

(23 citation statements)

References 59 publications

(69 reference statements)

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“…The nanochain could specifically target metastases in the liver and lung in a highly aggressive breast cancer tumor model. Similarly, we designed a pH‐sensitive wormlike micelle of succinobucol with a diameter of 20 nm and length in the range of 50–300 nm . The wormlike micelles could be specifically delivered to the sites of metastatic lesions in the lung, leading to remarkable prevention of lung metastasis in a 4T1 metastatic breast cancer model.…”

Section: Rational Regulation Of the Physicochemical Properties Of Nanmentioning

confidence: 99%

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhang

Wang

Tan

et al. 2018

Adv Funct Materials

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132

106

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The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment of tumor metastasis. This review outlines the current approaches and summarizes the rational design of nanoparticles with deep tumor penetration capacity for anti-metastasis treatment. There are two ways to achieve better tumor penetration; through rational regulation of the physicochemical properties of nanoparticles and through remodeling of the tumor microenvironment, including the tumor vasculature and stromal environment. Moreover, biomimetic strategies that integrate the advantages of nanoparticles and metastasis-homing molecules during cancer cell metastasis are discussed. These efforts have led to promising results in facilitating intratumoral permeation of various nanoparticles to enhance antitumor effects. The considerations and some feasible future directions for deep tumor penetration strategies are proposed to improve tumor metastasis therapies.

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Section: Rational Regulation Of the Physicochemical Properties Of Nanmentioning

confidence: 99%

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhang

Wang

Tan

et al. 2018

Adv Funct Materials

Self Cite

132

106

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“…To evaluate the in vivo targeting capability of IPMs to tumor sites and metastatic lymph nodes, the in vivo distribution was evaluated in a metastatic breast cancer model ( Figure 3A). The 4T1 murine cells, one of the most aggressive metastatic breast cancer cell lines, were used to develop the metastatic breast cancer model [29][30][31][32] . Free IR-780 easily precipitated in PBS (pH 7.4) at 0.15 mg/mL (as shown in Figure 2A), thus preventing its applicability for various in vivo measurements.…”

Section: In Vivo Targeting To Lymphatic Metastasis In Breast Cancermentioning

confidence: 99%

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

Tan

et al. 2017

Acta Pharmacol Sin

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Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer.

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“…The same group further developed SCB-loaded pH-responsive wormlike micelles for lung metastasis treatment. 161 …”

Section: Tumour Vascular Abnormalitiesmentioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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pH‐Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer

Cited by 34 publications

References 59 publications

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

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