Phadiatop—a novel IgE antibody screening test

Merrett, J.; Merrett, T. G.

doi:10.1111/j.1365-2222.1987.tb02034.x

Cited by 60 publications

(33 citation statements)

References 7 publications

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“…In case of a negative SPT, patients were tested for aeroallergens and food allergens by the Phadiatop blood test (Pharmacia Diagnostics AB, Uppsala, Sweden). 30,31 In case of negative outcomes of both the SPT and Phadiatop test, patients were assigned to the case group. For each case 4 control subjects were selected, matched for age and gender.…”

Section: Patients and Proceduresmentioning

confidence: 99%

Clinical differences between atopic and atopiform dermatitis

Brenninkmeijer

Spuls

Legierse

et al. 2008

Journal of the American Academy of Dermatology

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Section: Patients and Proceduresmentioning

confidence: 99%

Clinical differences between atopic and atopiform dermatitis

Brenninkmeijer

Spuls

Legierse

et al. 2008

Journal of the American Academy of Dermatology

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“…Among the study subjects, only the preva lence of seasonal rhinitis + conjunctivitis symptoms ever ( 14.5% in males and 17.6% in females) differed signi ficantly by sex. Seasonal asthma symptoms ever were reported by 7.2% of our subjects, asthma diagnosed by a doctor by 6.8% .…”

Section: Prevalence O F Rhinitis Hay Fever Symptoms and Asthma Accormentioning

confidence: 99%

“…Sweden). Phadiatop detects the presence o f specific serum IgE against common inhalant allergens (pollens, house dust mites, moulds and animal epi thelial [6].…”

Section: Serological Examinationsmentioning

confidence: 99%

Prevalence of Atopy and Pollinosis in the Adult Population of Switzerland (SAPALDIA Study)

Wüthrich

Schindler

Leuenberger

et al. 1995

Int Arch Allergy Immunol

307

170

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The Swiss SAPALDIA study is a large multicenter cross-sectional study initiated in 1991 to evaluate the relationship between environment and respiratory symptoms and diseases in adults, and included subjects from eight areas in Switzerland with distinctive environmental characteristics. We present here prevalence data for atopy, pollinosis and atopic asthma obtained from a random sample of 8,357 adults (18–60 years) assessed by standardized computer-based interview as well as by allergy skin prick tests (SPTs) (performed with Phazet) to grass, birch and Parietaria pollen, house dust mite, cat and dog epithelia and the moulds Alternaria and Cladosporium and by an in vitro allergy screen test (Phadiatop CAP FEIA system). On the basis of a positive Phadiatop (total 28.9%; males 32.9%, females 25.0%; p < 0.001) and/or a positive SPT (total 23%; males 25.0%, females 20.8%; p < 0.001), 32.3% of the study population were considered atopic (males 35.7%, females 28.8%; p < 0.001). Concerning the prevalence of skin sensitization (SPT wheal ≥ 3 mm), the highest rate was observed for grass (12.7%), followed by house dust mite (8.9%), silver birch (7.9%), cat (3.8%) and dog (2.8%), whereas moulds and Parietaria elicited less than 1% positive SPTs. The prevalence of atopic rhinitis (rhinitis symptoms associated with atopy) was 13.5% (males 14.3%, females 12.6%; p < 0.05) and the prevalence of current hay fever varied between 9.1% (questionnaire answer and a positive SPT to at least one pollen), 11.2% (questionnaire answer and presence of atopy) to 14.2% (questionnaire answer only) with no significant difference by sex. However, a significant difference for the prevalence rate of hay fever was observed between Swiss citizens with 11.6% and foreign citizens living in Switzerland with 8.7% (p < 0.01). Pollen-induced asthma (seasonal asthma symptoms and presence of a positive SPT to pollen) was judged to be present in at least 4.3%. These data confirm the high rate of atopy and atopic respiratory diseases in a western country. Taking into consideration the main differences in prevalence rates recorded in 1926 (0.82%), 1958 (4.8%) and 1986 (9.6%), the present survey demonstrates a further increase in self-reported current hay fever in Switzerland.

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“…Using asthma incidence definition from JACQUEMIN et al [30] (which corresponds to definition 3b except the outcome is based on self-report and may reflect undiagnosed asthma) Definition 3b except the outcome is based on self-report [29,32,33]. Allergically sensitised subjects with doctor-diagnosed asthma were considered as having allergic asthma.…”

Section: Definitionmentioning

confidence: 99%

Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

et al. 2015

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A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland and its relation to sex, taking into account age and allergic sensitisation.We assessed incidence of self-report of doctor-diagnosed asthma between 1991/1992 and 2010/2011 in 5128 subjects without asthma, aged 18-60 years at baseline. The age-related probability of asthma onset was analysed by logistic regression adjusting for potential confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was 1.99 (95% CI 1.54-2.57) overall, 3.21 (95% CI 2.12-4.85) among nonsensitised subjects, and 1.43 (95% CI 1.02-2.02) in sensitised subjects. The probability of asthma onset decreased with increasing baseline age in women but not in men. The higher probability of new asthma in sensitised compared with nonsensitised men was unrelated to age, whereas in women it decreased with age.Asthma incidence was higher in women than in men but decreased with increasing age. The female predominance was considerably stronger in nonsensitised adults compared with those with allergic sensitisation. @ERSpublications Female predominance in new-onset adult asthma decreased with age and was more pronounced in nonsensitised subjects

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Phadiatop—a novel IgE antibody screening test

Cited by 60 publications

References 7 publications

Clinical differences between atopic and atopiform dermatitis

Clinical differences between atopic and atopiform dermatitis

Prevalence of Atopy and Pollinosis in the Adult Population of Switzerland (SAPALDIA Study)

Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

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