Pharmaceutical and Personal Care Products (PPCPs) in the environment: Plant uptake, translocation, bioaccumulation, and human health risks

Keerthanan, S.; Jayasinghe, Chamila; Biswas, Jayanta Kumar; Vithanage, Meththika

doi:10.1080/10643389.2020.1753634

Cited by 174 publications

(66 citation statements)

References 134 publications

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“…Though there are countable reports on direct human health implications by these pharma compounds but can gradually lead to antibiotic resistance in them. The witnessed trend in drug distribution as in this case is similar to previous reports (Zheng et al 2020;Keerthanan et al 2020).…”

Section: Ecological Risk Assessment Of Pharmaceutical Compoundssupporting

confidence: 91%

Quantitative assessment of pharmaceutical drugs in a municipal wastewater and overview of associated risks

2022

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Pharmaceuticals compounds are the emerging contaminants known for their refractory and environmental persistence, which pose threat to flora and fauna. In the present study, the occurrence and possible contamination sources of four drugs, namely paracetamol, diclofenac, salbutamol and ceftriaxone in wastewater of Mysuru, India, were investigated. The said pharma compounds were analyzed in the effluent of select health care establishments and municipal wastewater treatment plant (MWWTP). The results revealed that diclofenac was omnipresent in all the samples with the peak concentration of 4.2 µg/mL, whereas salbutamol and ceftriaxone were in the range of 0.7–18.7 µg/mL and 1.25–29.15 µg/mL, respectively. In addition, paracetamol was detected only at the inlet of MWWTP with a concentration of 4.6 µg/mL. Surprisingly, the presence of relative amounts of these drugs in the treated water released from MWWTP was observed. Further, the ‘risk quotient method’ for ecological risk assessment was adopted to assess the magnitude of risk toward aquatic species. Next, the study employed the concept of citizen science to gather information on disposal and management methods of unused and expired medications at household and health care centers. This survey revealed that hospital discharges and community disposal of unused medicines contributed to incidence of pharmaceutical compounds in the local environment. Finally, a precise perspective and future challenge for the safe management of drugs are presented.

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Section: Ecological Risk Assessment Of Pharmaceutical Compoundssupporting

confidence: 91%

Quantitative assessment of pharmaceutical drugs in a municipal wastewater and overview of associated risks

2022

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“…Emerging pollutants and contaminants include disinfection byproducts, pharmaceuticals and Personal Care Products (PPCPs), and antimicrobial resistance, which are commonly found in municipal wastewater effluents [78,79], or even microplastics [80,81], found in terrestrial and aquatic environments [82][83][84]. These substances, through the trophic chain, also threaten biodiversity and risk humans' health [85][86][87]. An essential category of pollutants are the endocrine-disrupting compounds (EDCs) that can impair plant growth and soil microorganisms [88,89].…”

Section: Water Quality and Use Of Nonconventional Water Resourcesmentioning

confidence: 99%

Water Quality Focusing on the Hellenic World: From Ancient to Modern Times and the Future

Angelakιs

Dercas

Tzanakakis

2022

Water

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Water quality is a fundamental issue for the survival of a city, especially on dry land. In ancient times, water availability determined the location and size of villages and cities. Water supply and treatment methods were developed and perfected along with the evolution of urbanization. In Europe, after the fall of the Roman Empire, water supply and sewage systems went through fundamental changes. However, in medieval times, the lack of proper sanitation and low water quality increased the spreading and effects of epidemics. The importance of potable water quality was established during modern times. In Greece, the significance of water filtration and disinfection was not understood until the beginning of the 20th century. Moreover, the beneficial effects of water quality and sanitation on human health and especially on life expectancy are considered. In Greece and other countries, a dramatic increase in life expectancy mainly after the 2nd World War is probably due to the improvement of potable water quality and hygiene conditions. However, since the mid-20th century, new water quality issues have emerged, such as eutrophication, the improvement of water treatment technologies, as well as chemical and microbiological water pollution problems. This study, in addition to the historical evolution of water quality, highlights and discusses the current issues and challenges with regard to the management and protection of water quality, including global changes in population and urbanization, lack of infrastructure, use of nonconventional water resources, spreading of emerging pollutants and contaminants (e.g., antibiotics and microplastics), and climatic variability impacts. Against these, a review of the main proposed strategies and measures is presented and discussed to protect water quality and maintain water supplies for the future. Understanding the practices and solutions of the past provides a lens with which to view the present and future.

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“…Alongside the essential compounds, potentially toxic substances can also be accumulated and translocated in different plant organs if the growing medium used is contaminated. The mechanisms of PPCP uptake by plants have been studied recently due to the potentially harmful effects of consuming contaminated products sold on markets [72]. Ibuprofen, caffeine, and BPA were among the compounds that were frequently detected in plant samples.…”

Section: Frequently Detected Ppcps In Plantsmentioning

confidence: 99%

Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes

Reyes

Geronimo

Yano

et al. 2021

Water

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The procedures for analyzing pharmaceuticals and personal care products (PPCPs) are typically tedious and expensive and thus, it is necessary to synthesize all available information from previously conducted research. An extensive collection of PPCP data from the published literature was compiled to determine the occurrence, pathways, and the effectiveness of current treatment technologies for the removal of PPCPs in water and wastewater. Approximately 90% of the compiled published papers originated from Asia, Europe, and the North American regions. The incomplete removal of PPCPs in different water and wastewater treatment processes was widely reported, thus resulting in the occurrence of PPCP compounds in various environmental compartments. Caffeine, carbamazepine, diclofenac, ibuprofen, triclosan, and triclocarban were among the most commonly reported compounds detected in water and solid matrices. Trace concentrations of PPCPs were also detected on plants and animal tissues, indicating the bioaccumulative properties of some PPCP compounds. A significant lack of studies regarding the presence of PPCPs in animal and plant samples was identified in the review. Furthermore, there were still knowledge gaps on the ecotoxicity, sub-lethal effects, and effective treatment processes for PPCPs. The knowledge gaps identified in this study can be used to devise a more effective research paradigm and guidelines for PPCP management.

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Pharmaceutical and Personal Care Products (PPCPs) in the environment: Plant uptake, translocation, bioaccumulation, and human health risks

Cited by 174 publications

References 134 publications

Quantitative assessment of pharmaceutical drugs in a municipal wastewater and overview of associated risks

Quantitative assessment of pharmaceutical drugs in a municipal wastewater and overview of associated risks

Water Quality Focusing on the Hellenic World: From Ancient to Modern Times and the Future

Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes

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