Pharmaceutical Dissolution Testing

Banakar, Umesh V.

doi:10.1201/b14198

Cited by 90 publications

(69 citation statements)

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“…Drug content in dissolution sample was determined by calibration curve. [15,16] RESULTS AND DISCUSSION …”

Section: Disintegration Timementioning

confidence: 99%

“…Tablet was placed in the cylinder and complete dispersion of tablet in the cylinder was recorded as the disintegration time. [15,16] 9. Dissolution studie Sample volume of 10 ml was withdrawn at regular time intervals from a zone midway between the surface of dissolution medium and the top of rotating paddle not less than 1 cm apart from the vessel wall.…”

Section: Disintegration Timementioning

confidence: 99%

“…The wetted tablet was then weighed. Water absorption ratio R was determined using following equation: [15,16] (Wb -Wa) R = ------------------------- …”

Section: Water Absorption Ratiomentioning

confidence: 99%

See 2 more Smart Citations

Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

Aglawe¹

2017

WJPR

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The concept of Mouth Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouthdissolving tablets of oxcarbazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared. A mouth dissolving tablet was prepared by using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations F8 emerged as the best formulation and showed maximum dissolution rate.

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“…Drug content in dissolution sample was determined by calibration curve. [15,16] RESULTS AND DISCUSSION …”

Section: Disintegration Timementioning

confidence: 99%

Section: Disintegration Timementioning

confidence: 99%

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Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

Aglawe¹

2017

WJPR

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“…Dissolution efficiency (DE) (Banakar 1992) after 8 h of release test was used to compare the results of dissolution tests of different formulations:…”

Section: Data Fittingmentioning

confidence: 99%

Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel¹,

Chavda

2010

Braz. arch. biol. technol.

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“…and Japanese Pharmacopoeia as an official apparatus to study the dissolution profile of pharmaceutical solid dosage forms (47). The FTC reportedly has ideal hydrodynamic conditions for homogenous, mild agitation (48). It is of interest to explore this assertion and characterize the hydrodynamics within the apparatus, and studies have been conducted using CFD and velocimetric methods.…”

Section: Flow-through Dissolution Apparatusmentioning

confidence: 99%

Characterization and Simulation of Hydrodynamics in the Paddle, Basket and Flow-Through Dissolution Testing Apparatuses - A Review

Todaro¹,

Pearsons²,

Grove³

et al. 2017

Dissolution Technol.

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Fluid velocity local to the dissolving surface will affect the dissolution rate. It is difficult to anticipate what local fluid velocities are present within compendial dissolution apparatuses from set flow rates or stirring rates. A range of qualitative and quantitative velocimetric techniques are available to assess and characterize hydrodynamics. These methods are frequently used in combination with computational fluid dynamics simulations to characterize and simulate hydrodynamics. Dosage form location and motion varies between apparatuses, and the presence of the dosage form itself can impact local hydrodynamics. Each apparatus described has identified hydrodynamic features which may also vary with agitation rate. This review describes the methods used to simulate and characterize hydrodynamics and summarizes some of the main findings from studies investigating hydrodynamics in the paddle, basket, and flowthrough dissolution apparatuses.

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Pharmaceutical Dissolution Testing

Cited by 90 publications

References 0 publications

Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

Formulation and evaluation of glipizide floating-bioadhesive tablets

Characterization and Simulation of Hydrodynamics in the Paddle, Basket and Flow-Through Dissolution Testing Apparatuses - A Review

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