Pharmacodynamics of Propofol in Female Patients

Vuyk, Jaap; Engbers, Frank H. M.; Lemmens, Harry J. M.; Burm, A. G. L.; Vletter, A. A.; Gladines, M. P. R. R.; Bovill, J. G.

doi:10.1097/00000542-199207000-00002

Cited by 147 publications

(67 citation statements)

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“…The hypotensive property of propofol is dose dependent 8 and more obvious in elderly patients 9 . There is some evidence that the use of fentanyl with propofol induction may potentiate the hypotensive effect of propofol 10 .…”

Section: Discussionmentioning

confidence: 99%

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Rabadi¹

2013

Rev. Bras. Anestesiol.

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Background and objective: To compare the effect of prophylactic administration of normal saline against the hypotensive effect of propofol in female patients booked for gynecological procedures. Method: Sixty nine ASA (I, II) patients were randomly allocated into two groups, group 1 received 5 mL.kg -1 of 0.9% normal saline 10 minutes before induction, whereas group 2 received nothing (control). Anesthesia was induced with propofol and fentanyl then maintained with propofol and remifentanil. We measured hemodynamic variables pre and post general anesthesia induction. Results: Both groups had signifi cant drops in post induction mean arterial blood pressure (P < 0.001). Also both groups had signifi cant drops in post induction heart rate ((P < 0.02 in sample group and P < 0.001 in control group), and 35% of patients in the control group had more than 25% drop in the pre induction mean arterial blood pressure, compared with only 17% of patients in the saline group (P < 0.04). Conclusion: The prophylactic administration of normal saline could decrease the percentage of patients who had a signifi cant drop in their blood pressure after propofol induction of general anesthesia.

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Section: Discussionmentioning

confidence: 99%

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Rabadi¹

2013

Rev. Bras. Anestesiol.

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“…For example, the Cp 50 of propofol to prevent movement on skin incision is 16 μg/ml, but this is markedly decreased by increased concentrations of fentanyl or alfentanyl. 19,20,21 This level is further reduced to 2.5 μg/ml when combined with benzodiazepines (as premedication), 22 and to 1.7 μg/ml when lorazepam has been replaced as premedication by morphine (0.15 mg/ kg). 23 ICU patients are often sedated with a combination of a benzodiazepine and morphine.…”

Section: Intravenous Anaesthesiamentioning

confidence: 99%

Anaesthesia for ICU-based procedures: the advantages of and options available for inhalational anaesthesia

Kruger

2010

Southern African Journal of Anaesthesia and Analgesia

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“…However, it can promote a reduction in blood pressure (BP) and systemic vascular resistance (SVR), and as a rule those changes are not followed by a compensatory increase in heart rate (HR) 9,10,16 .…”

Section: Pharmacologymentioning

confidence: 99%