Pharmacognostic and pharmacological profile of Humulus lupulus L.

Zanoli, Paola; Zavatti, Manuela

doi:10.1016/j.jep.2008.01.011

Cited by 445 publications

(421 citation statements)

References 103 publications

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“…Quantification of xanthohumol, α-and β-acids in hop samples had been done by using HPLC with UV or MS detection (Berwanger et al, 2005;Zanoli & Zavatti, 2008;Kac & Vovk, 2007). The cis-and trans-iso-alphaacids of isomerized α-acids derivatives are known to have different UV-absorption spectra (Hughes, 2006).…”

Section: Characterization Of Bitter Acidsmentioning

confidence: 99%

“…Humulus lupulus L., Cannabaceae, (commonly named hops) is natural from central Europe and it is widely cultivated throughout the temperate regions of the world (Heinrich et al, 2004, Zanoli & Zavatti, 2008. The hop is one of major raw material in brewing, therefore, the economic value of the hop plant is derived from its worldwide application as an essential flavoring ingredient for the brewing of beer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic

Negri¹,

Santi²,

Tabach³

2010

Rev. bras. farmacogn.

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RESUMO:Humulus lupulus L., Cannabaceae, é usada como sedativo e ansiolítico na medicina popular. O método de HPLC-DAD-ESI-MS n representa uma ferramenta poderosa para a análise de produtos naturais, desde que ela fornece o espectro de UV e informações estruturais sobre os constituintes da mistura. O objetivo deste trabalho foi o de caracterizar os constituintes encontrados no extrato hidroalcoólico. Os constituintes 1-9 foram tentativamente caracterizados através do UV/DAD e ionização por electrospray (MS/MS) depois da separação usando fase reversa, tempo de retenção e dados da literatura. Os principais compostos fenólicos (baseados na área dos picos) foram caracterizados como ácido hulupínico (9), coulupona (8), dois alfaácidos amargos oxidados (principais constituintes), um deles sendo um derivado da coumulinona oxidada (5) e o outro um derivado da humulinona oxidada (7), junto com uma procianidina B (3) e os flavonoides rutina (4) e o canferol-7-O-rutinosídeo (6). Esta planta conhecida devido às suas propriedades ansiolíticas e por ser um componente da cerveja, mostrou derivados oxidados de alfa-ácidos, como principais constituintes do extrato hidroalcoólico. Unitermos: Humulus lupulus, flavonoides glicosídeos, derivados de alfa-ácidos amargos oxidados, HPLC/DAD/MS/MS.ABSTRACT: Humulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MS n represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.

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Section: Characterization Of Bitter Acidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic

Negri¹,

Santi²,

Tabach³

2010

Rev. bras. farmacogn.

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“…For example, the antioxidative activity of hops bitter acids and their analogues may contribute to a cancer preventive effect since they can quench free radicals which cause oxidation of the DNA in the body and thus cause genetic defects. Humulon has been known for its preventive effect against osteoporosis and for capability to hinder the growth of certain leukemia cells especially with the combination of vitamin D. The results of one recent study confirmed that beer components are protective against the genotoxic effects of heterocyclic amines on target organs associated with tumorigenesis "in vivo" [1,9]. It is also known that the isomerized bitter acids (isohumulones) might prevent the developments of noninsulin dependent diabetes and hyperlipidemia, improving insulin sensitivity in patients with type II diabetes [2].…”

Section: Introductionmentioning

confidence: 99%

“…Today, a wide range of the preparations containing hops extracts or hops-derived products are available on the market, in particular for use in the phytotherapy of sleep disorders or pain relief and in postmenopausal therapy. Increasing evidence reveals that the so-called hops bitter acids, which represent up to 30% of the total lupulin content of hops, prenylflavonoids and xanthohumol exhibit interesting effects on human health [1][2][3][4]. Also, it is well-known that hops and the brewing industry are strongly linked.…”

Section: Introductionmentioning

confidence: 99%

Supercritical carbon dioxide hops extracts with antimicrobial properties

et al. 2015

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Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 μg mL -1 . Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of α-acids, β-acids, iso-α-acids and xanthohumol in the samples were determined by HPLC.

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“…Among them its chemopreventive and anti-inflammatory properties are the most extensively investigated [1,2], and these are at least in part mediated via inhibition of the NFκB signaling pathway [3][4][5][6]. We have shown previously that XN inhibits hepatic inflammation and fibrosis in a murine model of non-alcoholic fatty liver disease (NAFLD) [6].…”

Section: Introductionmentioning

confidence: 99%