Pharmacognostic Evaluation and Establishment of Quality Parameters of Leaves of Prosopis cineraria

Singh, Varsha; Sara, Udaivir Singh; Rizvi, Aleza

doi:10.52711/0974-360x.2022.00102

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…More research is needed to isolate and characterise specific antioxidant chemicals found in these extracts, as well as to investigate their potential applications in functional foods, medicines, and natural health products. Antioxidants are essential for protecting cells and tissues against oxidative damage, which has been linked to a variety of health problems, including ageing and chronic diseases [24,25] . The variance in antioxidant activity reported here highlights the importance of considering both the plant part and the solvent utilised when studying or using plant extracts for antioxidant potential.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Effect of extraction solvent and plant part on the yield of phenolic compounds, plumbagin and biological activity of Plumbago zeylanica

Dwivedi,

Singh,

Singh

2023

J Pharmacogn Phytochem

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Plants have always been important in traditional medicine, providing an extensive range of bioactive chemicals that are still of interest to science today. The present study evaluates the effect of several extraction solvents and plant parts (i.e., leaf, stem, and root) on the production of phenolic compounds, flavonoids, plumbagin and biological activity of Plumbago zeylanica L. Bioactive components were extracted using solvents ranging in polarity from non-polar hexane to polar water. The study found significant changes in extract yields depending on the solvent and plant part used, with aqueous extraction giving the most chemicals. Plumbagin, which is predominantly contained in the root, was extracted most effectively with hexane, chloroform, and acetone solvents. Water extracts were notably high in phenolics, whereas ethanolic extracts were high in flavonoids. The study also assessed the biological activities of the extracts, including their antioxidant, antibacterial, and antifungal effects. Results indicated that acetone extracts displayed the highest antioxidant activity, with leaves generally exhibiting superior properties compared to stems and roots. The antibacterial activity against Grampositive bacteria was observed in hexane, chloroform, and acetone extracts, with plumbagin showing substantial antibacterial potential. In the case of antifungal activity, chloroform and acetone root extracts displayed significant inhibitory effects against Candida species, indicating potential use against fungal pathogens. This study focuses on the possible applications of Plumbago zeylanica L. and its constituents in medicine, pharmaceuticals, and other industries, highlighting the need of choosing the right solvent and plant part to produce the therapeutic benefits that are desired.

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Section: Antioxidant Activitymentioning

confidence: 99%

Effect of extraction solvent and plant part on the yield of phenolic compounds, plumbagin and biological activity of Plumbago zeylanica

Dwivedi,

Singh,

Singh

2023

J Pharmacogn Phytochem

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Preparation and Evaluation of Capsules containing Standardized Extract of Wild Hawthorn (Crataegus azarolus)

Badr

Muhammad

Ibrahim

2023

RJPT

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Wild Hawthorn (Crataegus azarolus) is a popular medicinal plant, rich in polyphenols and flavonoids, and has been associated with many beneficial properties including anticancer, cardioprotective, and antidepressant effects. This study aimed to prepare a standardized aqueous-alcoholic extract of the deried ariel parts of C. azarolus using two different extraction methods ((Magnetic mixer (MA), and ultrasonic-assisted extraction (Us)), determine the total phenolic and flavonoid content of the obtained extracts, and compare it with the international product, and prepare capsules containing this extract to investigate the effect of different types and concentrations of disintegrating agents on the release profile of this capsules. The findings showed that the yield obtained by both extraction methods is almost the same (MA: 19.9 %, US: 18.4 %) we obtained the flavonoids of the following components (MA extract: powder of the externally marketed drug: prepared dry drug powder) used at a concentration (10 : 350: 352) mg on (36.95: 4.56: 2.299) as a percentage of flavonoids Four different formulations were filled in the hard gelatin capsules using 120 mg of the prepared extract as an active ingredient. The effect of three types of superdisintigrant (croscarmellose Sodiuom ccNa, Microcrystallin cellouse 101, Sodiuom Strach Glycolate SSG) on the dissolution rate of the active ingredient was then investigated. The study showed that the formulation without superdisintigrant released its content faster than others, but all formulations release their content after 45 min. A comparison dissolution test was performed between the Capsules containing the best formulation and the capsules containing a powder of the local Crataegus plant as well as international marketed capsules containing the powder of the Crataegus plant. The study showed that the capsules filled wih the extract released it’s content better than the other after 45 min.

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Phytochemical, Antioxidant, and Cytotoxicity screenings of n-hexane extract from Blumea balsamifera L leaves

Rawati

Ginting

Maulana

et al. 2023

RJPT

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The significance of phytomedicine in the field of medicine has encouraged researchers to investigate the potential medicinal properties of plants. Of which, phytoconstituents of Blumea balsamifera have been reported to possess multiple pharmacological benefits. Unfortunately, recent published reports only cover the essential oils of B. balsamifera, obtained from hydro-distillation. Hence, our research aimed to explore the bioactivities of B. balsamifera leaves extracted with n-hexane solvent through partitioning. Firstly, simplicial powder of B. balsamifera leaves was macerated using methanol, and followed by partitioning in a separating funnel with n-hexane solvent. The sample was assayed with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and brine shrimp (Artemia salina) lethality test for antioxidant activity and cytotoxicity, respectively. Lastly, the phytochemical profile of the n-hexane extract was analyzed using gas chromatography – mass spectrometry (GC-MS). In the results, we found the n-hexane extract as a weak antioxidant (IC50=281.707ppm) and moderately cytotoxic agent (LC50=44.47ppm). GC chromatogram revealed the dominance of two phytoconstituents – borneol L (33.77%) and veridiflorol (22.57%), where both are known to have anticancer activities. In conclusion, bioactive and phytochemical screenings of n-hexane extract from Blumea balsamifera leaves suggested its anticancer potential. Future research involving purification of the phytocompound and investigation using cancer cell lines is encouraged.

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Pharmacognostic Evaluation and Establishment of Quality Parameters of Leaves of Prosopis cineraria

Cited by 3 publications

References 10 publications

Effect of extraction solvent and plant part on the yield of phenolic compounds, plumbagin and biological activity of Plumbago zeylanica

Effect of extraction solvent and plant part on the yield of phenolic compounds, plumbagin and biological activity of Plumbago zeylanica

Preparation and Evaluation of Capsules containing Standardized Extract of Wild Hawthorn (Crataegus azarolus)

Phytochemical, Antioxidant, and Cytotoxicity screenings of n-hexane extract from Blumea balsamifera L leaves

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