2019
DOI: 10.1080/17425255.2019.1575361
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Pharmacokinetic considerations for anti-epileptic drugs in children

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Cited by 23 publications
(17 citation statements)
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“…The analysis was performed collecting blood samples of three healthy rats (Wistar rat) at four different times (1, 3, 8 and 24 h) after single retro-orbital bolus administration (20 mg) with a total activity of 50 mCi. The volume of distribution (Vd) which estimates the distribution into extravascular tissues (tissue deposition) [37] was 0.00442 mg/l. This indicates that for the analysed period, high amount of 198 AuNC remains in plasma while is poorly distributed into the body.…”
Section: Pharmacokineticmentioning
confidence: 99%
“…The analysis was performed collecting blood samples of three healthy rats (Wistar rat) at four different times (1, 3, 8 and 24 h) after single retro-orbital bolus administration (20 mg) with a total activity of 50 mCi. The volume of distribution (Vd) which estimates the distribution into extravascular tissues (tissue deposition) [37] was 0.00442 mg/l. This indicates that for the analysed period, high amount of 198 AuNC remains in plasma while is poorly distributed into the body.…”
Section: Pharmacokineticmentioning
confidence: 99%
“…RE is a chronic and debilitating disease of the nervous system with epileptic seizure caused by accidental discharge of cerebral neurons, which may lead to stigma in patients (19)(20)(21). Therefore, appropriate inhibition of neuronal excitability is the key in selection of AEDs in RE children (22).…”
Section: Discussionmentioning
confidence: 99%
“…AED treatment is invariability present, taking into account drug-drug interactions and side effects, mainly in polytherapy (133)(134)(135).…”
Section: Treatmentsmentioning
confidence: 99%