Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound dressings

Miranda-Calderon, Laura; Yus, Cristina; Landa, Guillermo; Mendoza, Gracia; Arruebo, Manuel; Irusta, Silvia

doi:10.1016/j.ijpharm.2022.122003

Cited by 27 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the pH in chronic wounds varies between 5.45 and 8.65, due to the alkaline shift [ 57 ] caused by dissolved CO 2 , a reduction in oxygen tension and, possibly, by alkaline anions accumulation from bacterial metabolism. Therefore, pH-responsiveness of TC release at different pHs was suitable for wound healing with antibiotic exerting different release kinetics which will be perfectly matched for each wound type [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Hajidariyor

Nuntawad

Somsaen

et al. 2023

IJMS

View full text Add to dashboard Cite

Cryo-induced hydrogel from cellulose is a new class of biomaterials for drug delivery, cell delivery, bone and skin tissue engineering for cell proliferation and regeneration applications. This research aimed to synthesize cryo-induced hydrogel from cellulose and carboxymethyl cellulose (CMC) produced from empty bunch’s cell wall of Elaeis guineensis. First, the experiment was to produce cellulose-rich material using hot-compressed water extraction followed by alkaline delignification and bleaching with H2O2. The obtained bleached EFB cellulose was used as the substrate for CMC, and the optimal condition with the highest degree of carboxyl substitution (DS) of 0.75 was achieved when varying NaOH and monochloroacetic acid concentration as well as etherification temperature using fractional factorial design. For cryogelation study, hydrogels were synthesized from cellulose, CMC and beta-cyclodextrin (β-CD) by dissolving cellulose-based matrix in a NaOH/urea system, and the cellulose (CEL) solution was frozen spontaneously at −40 °C followed by high speed mixing to loosen cellulose fibrils. Epichlorohydrin (ECH) and Polyethylene glycol diglycidyl ether (PEGDE) were used as a cross-linker. First, the ratio of cellulose and CMC with different amounts of ECH was investigated, and subsequently the proper ratio was further studied by adding different crosslinkers and matrices, i.e., CMC and β-CD. From the result, the ECH crosslinked CMC-CEL (E-CMC-CEL) gel had the highest swelling properties of 5105% with the average pore size of lyophilized hydrogel of 300 µm. In addition, E-CMC-CEL gel had the highest loading and release capability of tetracycline in buffer solution at pH 7.4 and 3.2. At pH 7.4, tetracycline loading and release properties of E-CMC-CEL gel were 65.85 mg g−1 dry hydrogel and 46.48 mg g−1 dry hydrogel (70.6% cumulative release), respectively. However, at pH 3.2, the loading and release capabilities of Tetracycline were moderately lower at 16.25 mg g−1 dry hydrogel and 5.06 mg g−1 dry hydrogel, respectively. The findings presented that E-CMC-CEL hydrogel was a suitable material for antibiotic tetracycline drug carrying platform providing successful inhibitory effect on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Hajidariyor

Nuntawad

Somsaen

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…To what extent proton-sensing G protein–coupled receptors contribute to the detection of an external pH e gradient and pH tactic behavior is yet to be investigated in detail. In consideration of the chronic wound’s characteristic pH profile, both modulating pH e by applying pH-restoring hydrogel-like dressings [ 75 ] and the application of pH e responsive wound dressings have been recognized as a potential therapeutic strategy [ 50 , 103 ].…”

Section: Ph Taxis—directional Migration Along a Ph Gradientmentioning

confidence: 99%

pH-regulated single cell migration

Stock

2024

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Over the last two decades, extra- and intracellular pH have emerged as fundamental regulators of cell motility. Fundamental physiological and pathological processes relying on appropriate cell migration, such as embryonic development, wound healing, and a proper immune defense on the one hand, and autoimmune diseases, metastatic cancer, and the progression of certain parasitic diseases on the other, depend on surrounding pH. In addition, migrating single cells create their own localized pH nanodomains at their surface and in the cytosol. By this means, the migrating cells locally modulate their adhesion to, and the re-arrangement and digestion of, the extracellular matrix. At the same time, the cytosolic nanodomains tune cytoskeletal dynamics along the direction of movement resulting in concerted lamellipodia protrusion and rear end retraction. Extracellular pH gradients as found in wounds, inflamed tissues, or the periphery of tumors stimulate directed cell migration, and long-term exposure to acidic conditions can engender a more migratory and invasive phenotype persisting for hours up to several generations of cells after they have left the acidic milieu. In the present review, the different variants of pH-dependent single cell migration are described. The underlying pH-dependent molecular mechanisms such as conformational changes of adhesion molecules, matrix protease activity, actin (de-)polymerization, and signaling events are explained, and molecular pH sensors stimulated by H+ signaling are presented.

show abstract

“…CHXD-loaded L100-55 dressings are designed for use in infected chronic wounds, whereas the RIF-loaded S100 dressing is appropriate for acute wounds. 104…”

Section: Other Types Of Ph-responsive Wound Dressingsmentioning

confidence: 99%

“…98 Microneedles (MNs) are minimally invasive delivery systems that painlessly deliver drugs into subcutaneous tissues and are mainly used for the controlled and sustained release of hydrophilic drugs. 119–121 Ullah et al created a PLGA layer on stainless steel MNs and then coated them with Eudragit S100 (a type of pH-responsive material mentioned above 104 ), which enabled the pH-responsiveness of MNs. 99 Gelatin sponge is a frequently-used degradable wound dressing, in the study of Cui et al , CuO 2 was loaded into gelatin sponges.…”

Section: Other Types Of Ph-responsive Wound Dressingsmentioning

confidence: 99%