Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations

Koç, Feride; Üney, Kamil; Atamanalp, Muhammed; Tumer, I.; Kaban, Güzin

doi:10.1016/j.aquaculture.2009.06.004

Cited by 45 publications

(50 citation statements)

References 20 publications

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“…Following PO administration, the T 1/2ka (0.13 hr) of ENR was shorter compared with 0.82 hr in snakehead fish (Fang et al., ), 1.394 hr in Korean catfish (Kim et al., ), 1.99 hr in turbot scophthalmus maximus (Liang et al., ) and 6.03 hr in seabass (Intorre et al., ); this indicated that ENR was rapidly absorbed in crucian carp after gavage. T 1/2β and AUC of ENR in crucian carp treated orally were 62.17 hr and 162.72 μg hr/ml, respectively; the values were considerably higher than those determined in Korean catfish (Kim et al., ), brown trout (Koc, Uney, Atamanalp, Tumer, & Kaban, ) and snakehead fish (Fang et al., ), while they were considerably lower than those of turbot scophthalmus maximus (Liang et al., ) and European eel (Fang, Yu, Cai, Zhou, & Huang, ). The reason for those differences is not clear.…”

Section: Pharmacokinetic Parameters Of Enrofloxacin and Ciprofloxacinmentioning

confidence: 75%

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Fan

Wang

et al. 2017

Vet Pharm & Therapeutics

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The pharmacokinetics of enrofloxacin (ENR) was studied in crucian carp (Carassius auratus gibelio) after single administration by intramuscular (IM) injection and oral gavage (PO) at a dose of 10 mg/kg body weight and by 5 mg/L bath for 5 hr at 25°C. The plasma concentrations of ENR and ciprofloxacin (CIP) were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR or CIP concentrations using WinNonlin 6.1 software. After IM, PO and bath administration, the maximum plasma concentration (Cmax) of 2.29, 3.24 and 0.36 μg/ml was obtained at 4.08, 0.68 and 0 hr, respectively; the elimination half‐life (T1/2β) was 80.95, 62.17 and 61.15 hr, respectively; the area under the concentration–time curve (AUC) values were 223.46, 162.72 and 14.91 μg hr/ml, respectively. CIP, an active metabolite of enrofloxacin, was detected and measured after all methods of drug administration except bath. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in the crucian carp using IM, PO and bath immersion administration.

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Section: Pharmacokinetic Parameters Of Enrofloxacin and Ciprofloxacinmentioning

confidence: 75%

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Fan

Wang

et al. 2017

Vet Pharm & Therapeutics

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“…administration was 63.5 and 62.7 h, respectively; the values were considerably longer compared with 17.44 and 38.43 h in Korean catfish (Kim et al. , 2006) and 19.14 and 22.09 h in brown trout (Koc et al. , 2009).…”

Section: Discussionmentioning

confidence: 88%

Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio

Fang¹,

Liu²,

Liu³

et al. 2011

Vet Pharm & Therapeutics

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The pharmacokinetics of enrofloxacin (EF) was investigated after single intravenous (i.v.) and oral (p.o.) administration of 10 mg/kg body weight (b.w.) in 300 healthy allogynogenetic silver crucian carp at 24-26°C. The plasma concentrations of EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. After i.v. administration, the plasma concentration-time data were described by an open two-compartment model. The elimination half-life (T(1/2β)), area under the concentration-time curve (AUC) and total body clearance of EF were 63.5 h, 239.6 μg·h/mL and 0.04 L/h/kg, respectively. Following p.o. administration, the plasma concentration-time data showed a double peak-shaped curve, indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp. The maximum plasma concentration (C(max)), T(1/2β) and AUC of EF were 4.5 μg/mL, 62.7 h and 205.9 μg·h/mL, respectively. Absorption of EF was very good with a bioavailability (F) of 86%, which could be correlated with the unique structure of the alimentary canal in allogynogenetic silver crucian. CF, an active metabolite of EF, was not detected in this study.

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“…In previous studies, the pharmacokinetics of enrofl oxacin in different fi sh species have been described. The two-compartment model was found suitable for simulation in several studies after intravenous or oral administration (Intorre et al, 2000;Gore et al, 2005;Wu et al, 2006;Koc et al, 2009), while a one-compartment pharmacokinetic model was suitable for others (Bowser et al, 1992;Jian et al, 2005;Udomkusonsri et al, 2007). These differences might be due to different fi sh species, different water temperatures and/or different experimental protocols.…”

Section: The Comparative Pharmacokinetics Of Enrofl Oxacinmentioning

confidence: 96%

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

Liang

Zhao

et al. 2012

Chin. J. Ocean. Limnol.

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Turbot Scophthalmus maximus , an important aquaculture species in China, currently suffers from epizootic diseases because of high density aquaculture. Enrofl oxacin has been used to treat various systemic bacterial fi sh infections. However, studies concerning the pharmacokinetics of enrofl oxacin in turbot are limited. In this study, the pharmacokinetics of enrofl oxacin and its metabolite ciprofl oxacin, were investigated in the turbot following intravenous and oral administration at 10 mg enrofl oxacin/kg body weight, at 16°C and 10°C water temperatures. The concentrations of enrofl oxacin and ciprofl oxacin in the main tissues (plasma, muscle, liver and kidney) were detected by HPLC. The results show that the plasma concentration-time data for enrofl oxacin were best described as a two-compartment open model after intravenous and oral administration. Three pharmacokinetic equations were established between the concentrations and temperatures. The kinetic profi le of enrofl oxacin was temperature dependent. The absorption half-life of enrofl oxacin was 1.99 h and 2.17 h after oral administration, whereas the elimination half-life of the drug was 98.63 h and 136.59 h at 16°C and 10°C, respectively. The peak concentration of enrofl oxacin in plasma and tissues was higher at 16°C than that at 10°C, and the peak plasma concentration time in the liver was the shortest at both temperatures among those of other tissues. The plasma C max /MIC ratio varied between 11.08 and 5 540.00 at 16°C; and between 7.92 and 3 960.00 at 10°C. The AUC/MIC ratio was 467.82-280 690.00 at 16°C, and 359.48-215 690.00 at 10°C. These ratios indicate that it is possible to obtain therapeutic effi cacy. Very low levels of ciprofl oxacin were detected. The AUC ratios of ciprofl oxacin and enrofl oxacin in plasma suggest that plasma ciprofl oxacin might play a minor role in enrofl oxacin treatment for turbot.

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Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations

Cited by 45 publications

References 20 publications

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

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