“…In our study, using a population approach, experimental data were fitted to a two-compartmental model, in accordance with earlier reports on tobramycin disposition [4,14,15]. Estimated mean value of population for systemic clearance of tobramycin is very close to previously published data in horses [4]. Similar range of values have been reported for humansdsystemic clearance between 0.041 and 0.071 L/hr/kg; Vd ranged from 0.49 to 0.94 L/kg, and V 1 ranged from 0.294 to 0.335 L/kg [16,17].…”