Population Pharmacokinetics of Tobramycin in Horses

Milanova, Aneliya; Bakalov, Dinyo; Hubenov, H.; Lashev, L.

doi:10.1016/j.jevs.2011.12.010

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…And it was reported that adding body weight and creatinine clearance as covariates could improve the prediction ability. In contrast, gender as another covariate did not improve the prediction ability of the model ( 18 ). In another population pharmacokinetics study in the trout, it was found that the ploidy of fish had an impact on the pharmacokinetic results of enrofloxacin ( 19 ).…”

Section: Discussionmentioning

confidence: 81%

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

et al. 2022

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This study aimed to determine the population pharmacokinetics of danofloxacin in healthy Yellow River carp (Cyprinus carpio Haematopterus) after single oral administration at 10 mg/kg body weight (BW). A sparse sampling was applied in this study and plasma samples were randomly collected from the tail veins of six carp at 0.25, 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72, 96, 120 and 144 h after administration. A maximum of four plasma samples was collected from each carp. Then the concentrations of danofloxacin in plasma samples were determined through an HPLC method. Danofloxacin could be quantified in plasma up to 144 h after administration. The corresponding population pharmacokinetic modeling was developed according to the non-linear mixed effect method, including covariate and covariance models to explain some variations from unknown sources and improve the prediction ability. On the premise of sparse sampling, the typical values of the population (fixed effect) and inter-individual variation (random effect) were described by the current population pharmacokinetic model. The estimated typical values and coefficient of variation between individuals (CV%) of absorption rate constant (tvKa), apparent distribution volume (tvV) and clearance (tvCL) were 2.48 h−1 and 0.203%, 47.8 L/kg and 8.40%, 0.694 L/h/kg and 4.35%, respectively. The current danofloxacin oral dosing (10 mg/kg BW) can provide suitable plasma concentrations to inhibit those pathogens with MIC values below 0.016 μg/ml based on the calculated PK/PD indices of AUC/MIC or Cmax/MIC. Further studies are still needed to determine the in vitro and in vivo antibacterial efficacy of danofloxacin against pathogens isolated from Yellow River carp and finally draw a reasonable dosing regimen.

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Section: Discussionmentioning

confidence: 81%

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

et al. 2022

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“…Over the past 15 years, several peer‐reviewed NLME analyses in veterinary pharmacology have been published. The most recent examples include the study of topiramate in epileptic dogs (Vuu et al., ); nonsteroidal anti‐inflammatory drug (NSAIDs) in dogs and cats with osteoarthritis (Cox, Liao, Payne‐Johnson, Zielinski, & Stegemann, ; Fink et al., ; Pelligand, Soubret, King, Elliott, & Mochel, ; Silber et al., ); tobramycin in horses (Haritova, Bakalov, Hubenov, & Lashev, ); valnemulin and cefquinome in pigs (Zhao et al., , ); tulathromycin in lactating goats (Lin, Cuneo et al., ; Lin, Gehring et al., ); and penicillin G in cattle and swine (Li et al., ).…”

Section: Applications In Veterinary Medicinementioning

confidence: 99%

“…It proved to be particularly useful in the context of large interindividual variability, or where drug PK could be affected by the disease process or the drug itself (Sheiner, 1985). Because this modeling approach is amenable to sparsely sampled blood or tissue samples (Sheiner & Beal, 1983), it was later recognized to be of value in veterinary pharmacology to explore the impact of covariates such as age, sex, and disease status on drug PK (Martin-Jimenez & Riviere, 1998 (Haritova, Bakalov, Hubenov, & Lashev, 2012); valnemulin and cefquinome in pigs (Zhao et al, 2013(Zhao et al, , 2014; tulathromycin in lactating goats (Lin, Cuneo et al, 2016;; and penicillin G in cattle and swine (Li et al, 2014).…”

Section: Applications In Veterinary Medicinementioning

confidence: 99%

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed‐effects to characterize and quantify variability in drug pharmacokinetics

Bon

Toutain

Concordet

et al. 2017

Vet Pharm & Therapeutics

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A common feature of human and veterinary pharmacokinetics is the importance of identifying and quantifying the key determinants of between‐patient variability in drug disposition and effects. Some of these attributes are already well known to the field of human pharmacology such as bodyweight, age, or sex, while others are more specific to veterinary medicine, such as species, breed, and social behavior. Identification of these attributes has the potential to allow a better and more tailored use of therapeutic drugs both in companion and food‐producing animals. Nonlinear mixed effects (NLME) have been purposely designed to characterize the sources of variability in drug disposition and response. The NLME approach can be used to explore the impact of population‐associated variables on the relationship between drug administration, systemic exposure, and the levels of drug residues in tissues. The latter, while different from the method used by the US Food and Drug Administration for setting official withdrawal times (WT) can also be beneficial for estimating WT of approved animal drug products when used in an extralabel manner. Finally, NLME can also prove useful to optimize dosing schedules, or to analyze sparse data collected in situations where intensive blood collection is technically challenging, as in small animal species presenting limited blood volume such as poultry and fish.

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Doxycycline pharmacokinetics in mammalian species of veterinary interest – an overview

Mileva

Milanova

2022

BJVM

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Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies for refining dosage regimens in order to use this antibiotic reasonably. Additionally, the available data about population pharmacokinetics are reviewed as this approach exhibits a number of benefits in terms of determination of drug pharmacokinetics, prediction of drug disposition and interpretation of the variations in the pharmacokinetic parameters. Further research with animal species of veterinary interest and pathogens causing diseases in animals is needed to clarify the pharmacokinetics and pharmacodynamics of doxycycline.

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Population Pharmacokinetics of Tobramycin in Horses

Cited by 3 publications

References 20 publications

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed‐effects to characterize and quantify variability in drug pharmacokinetics

Doxycycline pharmacokinetics in mammalian species of veterinary interest – an overview

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