Pharmacokinetic study of schisandrin, schisandrol <scp>B</scp>, schisantherin <scp>A</scp>, deoxyschisandrin, and schisandrin <scp>B</scp> in rat plasma after oral administration of <scp>S</scp>hengmaisan formula by <scp>UPLC</scp>‐<scp>MS</scp>

Sun, Hui; Wu, Fangfang; Zhang, Aihua; Wei, Wenfeng; Han, Ying; Wang, Xijun

doi:10.1002/jssc.201200887

Cited by 37 publications

(35 citation statements)

References 21 publications

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“…UHPLC-MS was validated for simultaneous quantification of the five main bioactive components (i.e., schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B) in rat plasma after oral administration of SMS [71]. Validation proved the repeatability of the method was good and recovery was satisfactory.…”

Section: Pharmacokineticsmentioning

confidence: 95%

UHPLC-MS for the analytical characterization of traditional Chinese medicines

Wang

Zhang

et al. 2014

TrAC Trends in Analytical Chemistry

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Section: Pharmacokineticsmentioning

confidence: 95%

UHPLC-MS for the analytical characterization of traditional Chinese medicines

Wang

Zhang

et al. 2014

TrAC Trends in Analytical Chemistry

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“…Recently, mass spectrometry (MS) has been recognized as a tool yielding huge potential for high‐throughput discovery of lead compounds from HM . MS is highly critical to drug discovery and preclinical development needs.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry‐driven drug discovery for development of herbal medicine

Zhang

Sun

Wang

2016

Mass Spectrometry Reviews

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141

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Herbal medicine (HM) has made a major contribution to the drug discovery process with regard to identifying products compounds. Currently, more attention has been focused on drug discovery from natural compounds of HM. Despite the rapid advancement of modern analytical techniques, drug discovery is still a difficult and lengthy process. Fortunately, mass spectrometry (MS) can provide us with useful structural information for drug discovery, has been recognized as a sensitive, rapid, and high-throughput technology for advancing drug discovery from HM in the post-genomic era. It is essential to develop an efficient, high-quality, high-throughput screening method integrated with an MS platform for early screening of candidate drug molecules from natural products. We have developed a new chinmedomics strategy reliant on MS that is capable of capturing the candidate molecules, facilitating their identification of novel chemical structures in the early phase; chinmedomics-guided natural product discovery based on MS may provide an effective tool that addresses challenges in early screening of effective constituents of herbs against disease. This critical review covers the use of MS with related techniques and methodologies for natural product discovery, biomarker identification, and determination of mechanisms of action. It also highlights high-throughput chinmedomics screening methods suitable for lead compound discovery illustrated by recent successes.

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“…Professor Xijun Wang has been proved to be helpful to illuminate the effective constituents and metabolites of complex herbs and TCM prescription . It is suggested that only constituents absorbed into the blood have the opportunity to become active constituents after oral administration of TCM . Thus, developing a reliable and rapid analytical method for the characterization of the compounds from Radix Polygalae is necessary.…”

Section: Introductionmentioning

confidence: 99%

High‐throughput ultra high performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry method for the rapid analysis and characterization of multiple constituents of Radix Polygalae

Liu

Zhang

et al. 2016

J of Separation Science

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Radix Polygalae, the dried roots of Polygala tenuifolia and P. sibirica, is one of the most well-known traditional Chinese medicinal plants. It is an important medicinal plant that has been used as a sedative and to improve memory for a number of years in most of Asia. However, the in vivo constituents of the multiple constituents from Radix Polygalae remain unknown. In the current study, ultra high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and the MarkerLynx software combined with multiple data processing approach were used to study the constituents in vitro and in vivo. A rapid and efficient method for the characterization of multiple constituents in the herbal medicine Radix Polygalae by ultra high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry is described. In total, 35 compounds in the Radix Polygalae and 13 compounds absorbed into blood were characterized. Of the 35 compounds in vitro, ten were reported for first time. In the 13 compounds in vivo, six were prototype components and seven were metabolites were also elucidated for first time. This work narrowed the range of screening the potentially bioactive components and provided a basis for the quality control and mechanism of action.

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Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC‐MS

Cited by 37 publications

References 21 publications

UHPLC-MS for the analytical characterization of traditional Chinese medicines

UHPLC-MS for the analytical characterization of traditional Chinese medicines

Mass spectrometry‐driven drug discovery for development of herbal medicine

High‐throughput ultra high performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry method for the rapid analysis and characterization of multiple constituents of Radix Polygalae

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