Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder

Tani, Hiroko; Hikami, Susumu; Iizuna, Sanae; Yoshimatsu, Maiko; Asama, Takashi; Ota, Hidetaka; Kimura, Yuka; Tatefuji, Tomoki; Hashimoto, Ken; Higaki, Kazutaka

doi:10.1021/jf4048435

Cited by 60 publications

(69 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, significant attention has been given to the derivatives of resveratrol to overcome these drawbacks. For example, a recent study on the pharmacokinetics of gnetin C, a resveratrol dimer, showed increased bioavailability when orally consumed compared with resveratrol (38). Since the oligostilbenes in the present study showed improved potency in cancer chemoprevention compared with resveratrol, further investigation of their bioavailability is warranted.…”

Section: Discussionmentioning

confidence: 74%

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Gao

2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Paeonia suffruticosa from the section Moutan of the genus Paeonia is an important Chinese medicinal herb. In our previous study, 10 oligostilbenes from the seeds of P. suffruticosa, including trans-resveratrol and its dimers and trimers, were isolated and identified. In the present study, the anti-proliferative effects of these 10 oligostilbenes were systemically evaluated in a panel of human lung, breast and bone cancer cell lines, and their apoptotic effects were analyzed using a high-content multiplex apoptosis assay and a fluorescent caspase-3/7 assay. Furthermore, their anti-metastasis effects were examined in an invasive breast cancer cell line. Among the ten compounds, two resveratrol dimers, trans-and cis-gnetin H, showed the most potent anti-proliferative and anti-metastasis effects. All trans-oligostilbenes were more effective than their cis-forms, and trimers of resveratrol were more effective than dimers and the resveratrol isomer. The structure-activity relationships revealed that the polymerization degree, the double bond in the stilbene skeleton, and the steric arrangement and conformation of oligostilbenes obviously affected their antitumor potential. The results from this study provide valuable information for future semi-synthesis of resveratrol derivatives to develop novel cancer chemopreventive agents.

show abstract

Section: Discussionmentioning

confidence: 74%

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Gao

2017

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…A previous study reported that it reduced tumor cell proliferation by 5% in patients with colorectal cancer 49) . In contrast, few studies have examined MSE, with only two demonstrating its safety 29, 50) .…”

Section: Discussionmentioning

confidence: 99%

Trans-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model

Chiba

Kimura

Suzuki

et al. 2016

J Atheroscler Thromb

Self Cite

View full text Add to dashboard Cite

Aim: Resveratrol is a popular ingredient in dietary supplements. Some patients concomitantly use dietary supplements and medicines in Japan. In the present study, we determined whether trans-resveratrol and melinjo (Gnetum gnemon L.) seed extract (MSE), which contains resveratrol dimers, interacted with drugs using a mouse model.Methods: Male C57BL/6J mice were fed experimental diets containing 0.005%, 0.05%, or 0.5% (w/w) trans-resveratrol or MSE for 1 or 12 weeks. The expression of liver cytochrome P-450 (CYP) mRNA and activity of liver microsomal CYP were measured. To determine the influence of resveratrol or MSE on drug efficacy, the anticoagulant activity of warfarin was examined in mice that were fed diets containing trans-resveratrol or MSE for 12 weeks.Results: When the mice were fed experimental diets for 1 week, none of the doses of trans-resveratrol and MSE affected body weight, liver weight, or plasma AST and ALT levels. Trans-resveratrol also did not affect CYP1A1, CYP1A2, CYP2C, or CYP3A activities. In contrast, 0.5% MSE slightly increased CYP1A1 activity. When the mice were fed experimental diets for 12 weeks, 0.05% trans-resveratrol increased CYP1A1, CYP2C, and CYP3A activities, whereas 0.5% MSE suppressed CYP3A activity. Under these conditions, 0.5% trans-resveratrol enhanced the anticoagulant activity of warfarin, although CYP2C activity increased. However, MSE did not affect the anticoagulant activity of warfarin.Conclusion: The 0.05% trans-resveratrol did not interact with warfarin in a mouse model, whereas 0.5% trans-resveratrol may have enhanced the anticoagulant activity of warfarin.

show abstract

“…Common stilbenoids which are contained in the seeds of Gnetum gnemon are gnetin C, GC, GL, gnemoside A, GMA, GMC, GMD [2] and trans-resveratrol [6]. Among these stilbenoids, resveratrol is a compound that was found in 1940 to have wide biological activities.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Resveratrol from Melinjo (Gnetum gnemon L.) Seeds Using Mixtures of Liquid Carbon Dioxide and Ethanol

Mishima

Siregar

Kawamura

et al. 2015

SERDJ

View full text Add to dashboard Cite

The extraction of resveratrol from Melinjo seeds (Gnetum gnemon L.) using mixtures of liquid carbon dioxide (CO 2 ) and ethanol was performed at 5, 20 and 25 ºC. The extraction pressure was from 8 to 14 MPa.The extraction yields were compared with the yields obtained by other solvent extraction methods, such as pure liquid CO 2 extraction and conventional aqueous alcohol (methanol or ethanol) extraction. We conducted qualitative and quantitative analyses for resveratrol in the extract using HPLC and analyzed the extraction behavior. The effect of three operating parameters, temperature, pressure and composition of ethanol in liquid CO 2 , on the extraction yield was investigated using the single-factor method. The yields of resveratrol in the extraction were significantly improved by adjusting the operating temperature and the amount of ethanol in liquid CO 2 .

show abstract

Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder

Cited by 60 publications

References 33 publications

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

<i>Trans</i>-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model

Extraction of Resveratrol from Melinjo (<i>Gnetum gnemon L</i>.) Seeds Using Mixtures of Liquid Carbon Dioxide and Ethanol

Contact Info

Product

Resources

About