Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Zhang, Guozhe; Qi, Wen; Xu, Liangyu; Kano, Yoshihiro; Yuan, Dan

doi:10.1016/j.jchromb.2015.09.040

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…Currently, there are also some reports on identification of drug metabolites using hybrid mass analyzers, such as quadrupole/time-of-fight (QqTOF), linear ion trap/Orbitrap (LTQ-Orbitrap) ion-trap/time-of-flight (IT/TOF) and linear IT/FTICR (LTQ-FT-ICR), which provide accurate mass measurements in structural assignments that help with data interpretation. [17][18][19][20][21][22][23][24][25][26][27] On the basis of accurate tandem mass spectrometry (MS/MS) spectra and the known structures of AL and PR, we proposed the chemical structures for the metabolites detected.…”

mentioning

confidence: 99%

Identification of allocryptopine and protopine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Huang

Xiao

Sun

et al. 2016

Rapid Comm Mass Spectrometry

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mentioning

confidence: 99%

Identification of allocryptopine and protopine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Huang

Xiao

Sun

et al. 2016

Rapid Comm Mass Spectrometry

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“…In addition, calycosin was not detected in rat plasma, probably resulting from its strong phase II metabolism in liver. It was often found that high levels of phase II metabolites circulated in blood with trace amounts of aglycone in the pharmacokinetic profiles of isoflavones (Bai, Qu, Lu, Kano, & Yuan, ; Hosoda, Furuta, & Ishii, ; Qu et al, ; Tian et al, ; Wang, Gong, et al, ; Yuan et al, ; Zhang, Qi, Xu, Kano, & Yuan, ). Considerably different pharmacokinetics of CAG and calycosin have been published in the literature after rats were treated with TCM consisting of Huangqi (Liu et al, ; Liu et al, ; Shaw et al, ; Shi et al, ; Tao, Huang, Yang, Li, & Cai, ; Zeng et al, ; Zhang, Yang, Lin, & Hu, ).…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of major components of Huangqi–Honghua extract in rat plasma using LC–MS/MS and application to a pharmacokinetic study

Wang

Qiao

et al. 2019

Biomedical Chromatography

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A sensitive and reliable LC-MS/MS method was developed and validated for simultaneous quantification of the major components of Huangqi-Honghua extact in rat plasma, including hydroxysafflor yellow A (HSYA), astragaloside IV (ASIV), calycosin-calycosin-3′-O-sulfate (C-3′-S). After extraction by protein precipitation with acetonitrile and methanol from plasma, the analytes were separated on a Hypersil BDS C 18 column by gradient elution with acetonitrile and 5 mM ammonium acetate. The detection was carried out on a triple quadrupole tandem mass spectrometer equipped with electrospray ionization source switched between negative and positive modes.HSYA was monitored in negative ionization mode from 0 to 4.9 min, and ASIV, CAG, calycosin, C-3′-G and C-3′-S were determined in positive ionization mode from 4.9 to 10 min. The lower limits of quantification of the analytes were 6.25 ng/mL for HSYA, 0.781 ng/mL for CAG and 1.56 ng/mL for ASIV and calycosin. The intra-and inter-assay precision (RSD) values were within 13.43%, and accuracy (RE) ranged from −8.75 to 9.92%. The validated method was then applied to the pharmacokinetic study of HSYA, ASIV, CAG, calycosin, C-3′-G and C-3′-S in rat after an oral administration of Huangqi-Honghua extract.

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“…For example, after oral administration of kakkalide, many related metabolites were detected in rat plasma, and kakkalide only accounted for a small part of the content of metabolites [29]. Many metabolites were also detected in the plasma of rat after oral administration of irisolidone, especially glucuronide metabolites and sulfate metabolites [23].…”

Section: Application Of Pharmacokinetic Study In Wistar Ratsmentioning

confidence: 99%

Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin

Zhang

Sun

et al. 2020

Journal of Analytical Methods in Chemistry

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Puerarin is the main biologically active isoflavone in Pueraria lobata and has a wide range of biological activities. However, due to its poor water solubility and low oral bioavailability, its clinical applications are restricted. Compared with puerarin, the Pueraria lobata extract (PLE) has better water solubility, lower toxicity, and less side effects. In this study, the pharmacokinetics of orally administered puerarin (100 mg/kg) and PLE (763 mg/kg, equivalent to 100.0 mg/kg of puerarin) to rats was investigated by the UHPLC-MS/MS method. Results showed that when the rats were administered PLE, the area under the concentration-time curve from zero to infinity (AUC0-inf) dramatically increased from 219.83 ± 64.37 μg h/L to 462.62 ± 51.74 μg h/L (p<0.01). The elimination half-time (t1/2) also increased from 1.60 ± 0.38 h to 12.04 ± 5.10 h (p<0.01). The maximum concentration (Cmax) of puerarin decreased from 101.64 ± 41.82 ng/mL to 48.64 ± 21.47 ng/mL (p<0.01), and time to reach the maximum plasma concentration (Tmax) of puerarin decreased from 1.46 ± 1.08 h to 0.54 ± 0.30 h (p<0.01). Results indicated that the pharmacokinetics of puerarin in Pueraria lobata may be dramatically different from pure puerarin in the plasma of rat, and oral bioavailability of puerarin may be increased when PLE was administrated to rats.

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Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Cited by 9 publications

References 22 publications

Identification of allocryptopine and protopine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Identification of allocryptopine and protopine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Simultaneous determination of major components of Huangqi–Honghua extract in rat plasma using LC–MS/MS and application to a pharmacokinetic study

Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin

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