1987
DOI: 10.2165/00003088-198713030-00004
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Pharmacokinetics of Lignocaine and Bupivacaine in Surgical Patients Following Epidural Administration

Abstract: The pharmacokinetics of lignocaine (lidocaine) and bupivacaine following epidural administration were studied in 12 surgical patients using a stable isotope method. Shortly after epidural administration of the agent to be evaluated, a deuterium-labelled analogue was administered intravenously. Plasma concentrations of the unlabelled and the deuterium-labelled local anaesthetics were determined using gas chromatography and mass fragmentography. The pharmacokinetic behaviour of both agents was consistent with a … Show more

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Cited by 76 publications
(8 citation statements)
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“…This and the visible trends in the standardized regression residuals (Fig 3A and 3C and Fig 4A and 4C) warranted the rejection of the “null hypothesis” Model A despite its lower AIC value as compared to model B. Other investigators already have reported such biphasic absorption kinetics for lidocaine and other local anaesthetics in human beings [2226]. The mechanistic basis of this model cannot be ascertained from our data, but at least 4 options are possible.…”
Section: Discussionsupporting
confidence: 58%
“…This and the visible trends in the standardized regression residuals (Fig 3A and 3C and Fig 4A and 4C) warranted the rejection of the “null hypothesis” Model A despite its lower AIC value as compared to model B. Other investigators already have reported such biphasic absorption kinetics for lidocaine and other local anaesthetics in human beings [2226]. The mechanistic basis of this model cannot be ascertained from our data, but at least 4 options are possible.…”
Section: Discussionsupporting
confidence: 58%
“…When bupivacaine is administered as a bolus injection in the epidural space, the maximal intravenous concentrations will be reached after 18 min. Epidural injection of bupivacaine 150 mg will result in peak plasma concentration of, on average, (14). Therefore, the prolongation of atracurium-induced neuromuscular blockade in the present study may be caused by bupivacaine reaching the neuromuscular junction through the blood stream.…”
Section: Discussionmentioning
confidence: 63%
“…A pharmacokinetic study indicates that little or no ( 14). Bupivacaine enters the general circulation mainly via the veins.…”
Section: Discussionmentioning
confidence: 99%
“…These parameters present a large interindividual variability (>50%). Total plasma clearance and central volume of distribution of bupivacaine was described previously after epidural administration of bupivacaine in 12 surgical patients,[19] it was averaged 520 ml/min for clearance and 68 L for steady state volume of the central compartment. And following a 10 min intravenous infusion of the race mate (dose 30 mg) in 10 healthy males;[20] the total plasma clearance of R (+)-bupivacaine (395 ± 76 ml/min) was greater than that of S (−)-bupivacaine (317 ± 67 m1/min).…”
Section: Discussionmentioning
confidence: 99%