Pharmacokinetics of plantamajoside and acteoside from Plantago asiatica in rats by liquid chromatography–mass spectrometry

Li, Yujuan; Gan, Lu; Li, George Q.; Deng, Li; Zhang, Xinshi; Deng, Yulin

doi:10.1016/j.jpba.2013.11.014

Cited by 45 publications

(31 citation statements)

References 19 publications

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“…Employing a protocol based on previous pharmacokinetic research methods (Li et al, 2014), analytes were separated on an Agilent Zorbax C18 column (Santa Clara, CA). As to the mobile phase, it contained solvent A (methyl alcohol) and solvent B (the content of methane acid in ddH 2 O being 0.1%).…”

Section: Methodsmentioning

confidence: 99%

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Zhao

Wang

et al. 2015

Mol Pharmacol

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Pneumolysin (PLY), an essential virulence factor of Streptococcus pneumoniae (pneumococcus), can penetrate the physical defenses of the host and possesses inflammatory properties. The vital role PLY plays in pneumococcus pathogenesis makes this virulence factor one of the most promising targets for the treatment of pneumococcal infection. Verbascoside (VBS) is an agent that does not exhibit bacteriostatic activity but has been shown to inhibit PLY-mediated cytotoxicity. The results from molecular dynamics simulations and mutational analysis indicated that VBS binds to the cleft between domains 3 and 4 of PLY, thereby blocking PLY's oligomerization and counteracting its hemolytic activity. Moreover, VBS can effectively alleviate PLY-mediated human alveolar epithelial (A549) cell injury, and treatment with VBS provides significant protection against lung damage and reduces mortality in a pneumococcal pneumonia murine model. Our results demonstrate that VBS is a strong candidate as a novel therapeutic in the treatment of Streptococcus pneumoniae infection.

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Section: Methodsmentioning

confidence: 99%

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Zhao

Wang

et al. 2015

Mol Pharmacol

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“…Its moderate elimination made less possibility of organ injury [130,131]. Interestingly, double peaks were seen from concentration-time curve of 121 in rat plasma [131,132]. And its absolute bioavailability was 0.12% [133].…”

Section: Pharmacokinetics Of Echinacoside (117) and Acteoside (121)mentioning

confidence: 99%

“…The pharmacokinetic results showed 138 was quickly absorbed in rats with the time of 16.7 min to maximum plasma concentration (C max , 172.3˘35.1 ng/mL). The elimination rate constants was 0.28˘0.01 L/h and T 1/2 was 2.46˘1.0 h [132]. Pharmacokinetics of tyrosol galactoside (140) following oral and i.v.…”

Section: Pharmacokinetics Of Other Phgsmentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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“…The structure of acteoside ( Fig. 1) was identified by spectroscopic techniques (HPLC and NMR) (9). The purity of acteoside was ≥99% based on the HPLC analysis with a wavelength of 333 nm.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of acteoside against X-ray-induced damage in human skin fibroblasts

Yang

Yao

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. To investigate the protective effects of acteoside against apoptosis induced by X-ray radiation in human skin fibroblasts (HSFs), the cells were divided into the following groups: Control group; X-ray radiation group; acteoside group, in which the confluent cells were preincubated with 50 µg/ml acteoside for 2 h followed by radiation; and positive control group, in which the cells were preincubated with 50 µg/ml paeoniflorin followed by radiation. For the radiation, HSF cells preincubated with acteoside or paeoniflorin were exposed to X-ray beams at a dose-rate of 3 Gy/min (16 Gy in total). Cell viability, apoptosis and intracellular alteration of redox were monitored by MTT and flow cytometry. Compared with the radiation group, the number of cells arrested at the G0/G1 phase was significantly reduced in the acteoside and paeoniflorin groups, respectively (P<0.05). X-ray radiation induced marked apoptosis in HSF cells and acteoside reversed this effect. Compared with the radiation group, the generation of intracellular reactive oxygen species (ROS) was abrogated by pre-incubation with acteoside or paeoniflorin (P<0.05). In addition, the upregulation of pro-caspase-3 induced by radiation was reversed by acteoside or paeoniflorin. Radiation could induce upregulation of Bax and downregulation of Bcl-2; however, it was reversed completely after administration of acteoside or paeoniflorin. Furthermore, the enhanced expression of ERK and JNK induced by radiation was reversed by acteoside or paeoniflorin. Acteoside could protect the cells from X-ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen-activated protein kinase signaling pathways.

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Pharmacokinetics of plantamajoside and acteoside from Plantago asiatica in rats by liquid chromatography–mass spectrometry

Cited by 45 publications

References 19 publications

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Protective effects of acteoside against X-ray-induced damage in human skin fibroblasts

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