Pharmacologic treatment of psychiatric disorders associated with epilepsy

Blumer, Dietrich; Zielinski, Janusz J.

doi:10.1016/s0896-6974(88)80119-1

Cited by 39 publications

(22 citation statements)

References 16 publications

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“…As expected from our previous experience (29,30), both preoperative and postoperative psychiatric complications of partial epilepsy responded well to antidepressant or double antidepressant medication. This result is of major importance, because chronic mesial temporal epilepsy in general, and its surgical treatment in particular, are associated with a high incidence of psychiatric complications.…”

Section: Discussionsupporting

confidence: 84%

Psychiatric Outcome of Temporal Lobectomy for Epilepsy: Incidence and Treatment of Psychiatric Complications

et al. 1998

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Summary: Purpose: To determine the incidence of psychiatric disorders before and after surgical treatment for partial epilepsy and to document the effectiveness of their treatment.Methods: Fifty consecutive patients treated surgically for focal epilepsy (44 temporal and six frontal) were evaluated by established neuropsychiatric methods before surgery and over a mean period of 2 years after surgery. The patients with interictal dysphoric disorders, with or without psychotic episodes, were treated witli tricyclic antidepressant medication alone or combined with serotonin selective reuptake inhibitors and, if necessary, with the addition of risperidone.Results: Before surgery, 25 (57%) of the 44 patients with temporal lobe epilepsy had dysphoric disorders. After surgery, 17 (

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Section: Discussionsupporting

confidence: 84%

Psychiatric Outcome of Temporal Lobectomy for Epilepsy: Incidence and Treatment of Psychiatric Complications

et al. 1998

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“…For example, certain patient series have shown that up to 80% of patients with epilepsy report feelings of depression (1, 2, 7), while endogenous depression has been found in up to 40% of patients in some epilepsy centers (2,8). Some investigators have suggested that 20% of temporal lobe epilepsy (TLE) patients become depressed and that up to 62% of patients with intractable complex partial seizures (CPSs) have had a history of a depressive episode, which, at times, may be recurrent (9,10).…”

Section: What Neurologists Should Know About the Epidemiologic Aspectmentioning

confidence: 99%

“…Furthermore, the clinical evidence shows that depressive symptoms in epileptic patients can be treated with modest doses of ADs, equivalent to half of the doses required for depressive disorders in nonepileptic patients. Thus, patients should be started at low doses with small increments until the desired clinical response is reached; this will minimize the risk of causing and/or exacerbating seizures (10,105,106).…”

Section: Proconvulsant Properties Of Adsmentioning

confidence: 99%

Depression in Epilepsy: A Common but Often Unrecognized Comorbid Malady

Kanner

Palac

2000

Epilepsy & Behavior

152

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“…Timely use of psychopharmacological agents such as antidepressant medications is recommended, and an attempt to achieve carbamazepine mono therapy in the epileptic patient with pseudoseizures is rewarding at times (Blumer and Zielinski, 1988;Trimble, 1986).…”

Section: Treatmentmentioning

confidence: 99%

Convulsive Pseudoseizures: A Review of Current Concepts

Savard

Andermann

1990

Behavioural Neurology

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Convulsive pseudoseizures thought to represent psychiatric disease can usually be detected early if they are considered in the epileptologist's differential diagnosis. No single diagnostic criterion for this behavioural disorder is known to be pathognomonic. Epilepsy and all physiological explanations have to be thoroughly ruled out and positive evidence of relevant psychopathology has to be gathered. The presence of pseudo seizures often heralds severe psychopathology, most frequently major affective disorder and major personality disorder, and occasionally, factitious disorder. Pseudoseizures can coexist with epileptic seizures and are often triggered by anticonvulsant toxicity. Diagnostic problems are more likely to be encountered in patients with frontal or parietal epilepsies, and in patients whose severe psychopathology is refractory to psychiatric intervention.

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Pharmacologic treatment of psychiatric disorders associated with epilepsy

Cited by 39 publications

References 16 publications

Psychiatric Outcome of Temporal Lobectomy for Epilepsy: Incidence and Treatment of Psychiatric Complications

Psychiatric Outcome of Temporal Lobectomy for Epilepsy: Incidence and Treatment of Psychiatric Complications

Depression in Epilepsy: A Common but Often Unrecognized Comorbid Malady

Convulsive Pseudoseizures: A Review of Current Concepts

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