Pharmacological actions of Thespesia populnea relevant to Alzheimer's disease

Mani, Vasudevan; Parle, Milind

doi:10.1016/j.phymed.2006.01.007

Cited by 82 publications

(59 citation statements)

References 45 publications

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“…Abnormal accumulation of cholesterol increases Ab in cellular and most animal models of Alzheimer disease, and drugs that inhibit cholesterol synthesis lower Ab in these models (Mori et al, 2001;Puglielli et al, 2003). Our previous finding indicated that the animals treated with TPE showed significant reduction in cholesterol levels in young and aged mice compared with control group (Vasudevan & Parle, 2007). Therefore, it seems likely that Thespesia populnea may prove to be a useful anti-Alzheimer agent, in view of its memoryenhancing property observed in the current study.…”

Section: Discussionsupporting

confidence: 55%

“…Selective loss of cholinergic neurons and decrease in cholinacetyltransferase activity was reported to be a characteristic feature of senile dementia of the Alzheimer type (Agnolli et al, 1983). The results of our previous study indicated that TPE showed elevation of acetylcholine level by significant reduction of cholinesterase activity in brain of young and aged mice (Vasudevan & Parle, 2007).…”

Section: Discussionmentioning

confidence: 90%

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Memory-Enhancing Activity ofThespesia populnea. in Rats

Mani

Parle

2007

Pharmaceutical Biology

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Thespesia populnea Soland ex. Correa (Malvaceae) is a large tree found in the tropical regions and coastal forests of India. Various parts of Thespesia populnea are found to possess useful medicinal properties such as antifertility, antibacterial, anti-inflammatory, antioxidant, purgative, and hepatoprotective activities. The current study was undertaken to investigate the effects of Thespesia populnea bark on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-, and ageing-induced amnesia served as the interoceptive behavioral models. The ethanol extract of Thespesia populnea (TPE) was administered orally in three doses (100, 200, and 400 mg=kg) for 7 successive days to different groups of young and aged rats. TPE (200 and 400 mg=kg, p.o.) resulted in significant improvement in memory of young and aged rats. TPE also reversed the amnesia induced by scopolamine (0.4 mg=kg, i.p.) and diazepam (1 mg=kg, i.p.). Cholesterol-lowering, anticholinesterase, anti-inflammatory, and antioxidant properties of Thespesia populnea may favorably contribute to its memory-enhancement effect. Therefore, Thespesia populnea bark appears to be a promising candidate for improving memory, and it would be worthwhile to explore the potential of this plant in the management of Alzheimer patients.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 90%

Memory-Enhancing Activity ofThespesia populnea. in Rats

Mani

Parle

2007

Pharmaceutical Biology

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“…Learning means obtaining knowledge and memory is considered as the retention of the acquired knowledge, which can be recalled as and when needed 1 . Memory is the capability of an individual to record sensory stimuli, events, information etc., which can be stored over a short or a long period of time and recalled when needed 2 .…”

Section: Introductionmentioning

confidence: 99%

Commiphora Berryi Ameliorating Effect on Scopolamine-Induced Memory Impairments in Mice

Dhivya¹,

Selvamani²,

Latha³

2017

Int. Res. J. Pharm.

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In the present study, we studied the effects of the ethanol extract of Commiphora berryi bark on drug-induced learning and memory-impaired mice using Y-maze task and passive avoidance task. On pretreatment with the ethanol extract of Commiphora berryi at 100mg/Kg p.o significantly ameliorated scopolamine-induced cognitive impairments which were revealed by the reversal in the reduction of spontaneous alteration in the Y -maze task and by significant improvement in latency time in passive avoidance task. This confirms the presence of bioactive phytoconstituents in Commiphora berryi which could be useful to decline the cognitive deficits in memory-impaired mice.

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“…An ayurvedic preparation contains Thespesia populnea, namely "panchvalkala" posses' free radical scavenging activity [17]. The barks and flowers posses astringent, hepatoprotective, antioxidant and anti-inflammatory activities in rats [18], [19], [20], [21] and also supposed to improve the memory [22].…”

Section: Introduction:-mentioning

confidence: 99%

“…Seeds encased in plant contains monoterpenes (α-pinene, Sabinene) [16][17], diterpenes (Helikauranoside) [18], oleic acid, triacyl glycerol, alkaloids, cyanogenic glycosides, saponins, cardiac glycosides, tannins, fixed oils, flavanoids [19], sesquiterpenes lactones [18] and alkaloids [20]. Flowers contain quercimeritrin, anthocyanin, abundant amount of cholin and betain, triterpene [21] and saponins [22]. Seeds contain 45 to 48 percent fixed oil, tannins [23] and polyphenols [24].…”

Section: Introduction:-mentioning

confidence: 99%