Pharmacological Activity of a Few Transition Metal Complexes: A Short Review

Selvaganapathy, Muthusamy; Raman, Natarajan

doi:10.4172/2572-0406.1000108

Cited by 75 publications

(46 citation statements)

References 173 publications

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“…In addition, this chelating agent shows better anti‐tumour activity through chelation with metal ions. This will be more permeable through cell membranes eventually behave as carriers of anti‐tumour agents . The results of our study supported the finding that chelation of metal ions Cu(II), Cd(II), Ni(II), Co(II), Cr(III), Fe(III) and Mn(II) with HL and 1,10‐phen enhanced the activity compared with 1,10‐phen itself.…”

Section: Resultssupporting

confidence: 87%

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

El‐Halim

Mohamed

Anwar³

2017

Applied Organom Chemis

104

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A new Schiff base ligand (HL) was prepared via a condensation reaction of quinoline-2-carboxaldhyde with 2-aminophenol in a molar ratio of 1:1. Its transition metal mixed ligand complexes with 1,10-phenanthroline (1,10-phen) as co-ligand were also synthesized in a 1:1:1 ratio. HL and its mixed ligand complexes were characterized using elemental analysis, infrared, 1 H NMR, mass and UV-visible spectroscopies, molar conductance, magnetic measurements, solid reflectance, thermal analysis, electron spin resonance and X-ray diffraction. Molar conductance measurements showed that all complexes have an electrolytic nature, except Cd(II) complex. From elemental and spectral data, the formulae [M(L)(1,10-phen)(H 2 O)] Cl x ⋅nH 2 O (where M = Cr(III) (x = n = 2), Mn(II) and Ni(II) (x = 1, n = 2), Fe(III) (x = n = 2), Co(II), Cu(II) and Zn(II) (x = 1, n = 2)) and [Cd(L)(1,10-phen) Cl]⋅3H 2 O for the metal complexes have been proposed. The geometric structures of complexes were found to be octahedral. Powder X-ray diffraction reflected the crystalline nature of the complexes; however, the Schiff base is amorphous. HL and its mixed ligand complexes were screened against Gram-positive bacteria (Streptococcus pneumoniae and Bacillus subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). Antifungal activity was determined against Aspergillus fumigatus and Candida albicans, the data showing that most complexes had activity less than that of the Schiff base while Mn(II), Fe(III) and Ni(II) complexes showed no significant antifungal activity. The anticancer activity of HL and its metal complexes was also studied against breast and colon cell lines. The metal complexes showed IC 50 higher than that of HL, especially the Cu(II) complex which showed the highest IC 50 against breast cell line.

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Section: Resultssupporting

confidence: 87%

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

El‐Halim

Mohamed

Anwar³

2017

Applied Organom Chemis

104

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“…Schiff bases are characterized as bidentate, tridentate, tetradentate and polydentate ligands. If these ligands contain functional groups such as ‐OH, ‐NH 2 , ‐SH, they can form stable complexes with transition metal ions …”

Section: Introductionmentioning

confidence: 99%

“…When the N‐ligands are attached with metal ions, they form strong σ‐donors but their П‐character depends on the frameworks. In addition to N‐, O‐, S‐ and P‐ ligands also exist, where O‐ligands classified as hard but S‐ and P‐ ligands are considered soft based on hard‐soft acid base Pearson's scale …”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Structures and Various Biological Applications of New Zn(II) Complexes Having Different Coordination Modes Controlled by the Drug Furosemide in Presence of Bioactive Nitrogen Based Ligands

Raymoni

Ali

2018

Applied Organom Chemis

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Novel Zn(II) complexes with the general formula: [Zn(furo) 2 (L) n ], n = 1 or 2, (furo = furosemide = (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid) were prepared. The complexes [Zn(furo) 2 (MeOH) 2 ] (1; MeOH = methanol), [Zn(furo) 2 (2-ampy) 2 ] (2; 2-ampy = 2-aminopyridine), [Zn(furo) 2 (2-ammepy) 2 ] (3; 2-ammepy = 2-aminomethylpyridine), [Zn(furo) 2 (H 2 O)(2,2-bipy)] (4; 2,2′bipy = 2,2′-bipyridine), [Zn(furo) 2 (H 2 O)(4,4′-bipy)] (5; 4,4′-bipy = 4,4′bipyridine), [Zn(furo) 2 (1,10-phen)] (6; 1,10-phen = 1,10-phenanthroline),[Zn(furo) 2 (2,9-dmp)] (7; 2,9-dmp = 2,9-dimethyl-1,10-phenanthroline), and [Zn (furo) 2 (quin) 2 ] (8; quin = quinoline) were synthesized and characterized using different techniques such as IR, UV-Vis, 1 H NMR, 13 C NMR, LC/MS and others. The crystal structure of complex (4) was determined using singlecrystal X-ray diffraction.The anti-bacterial activity of complexes (1-8) was tested using agar diffusion method against three gram-positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram-negative bacteria (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa). The obtained results showed different Inhibition Zone Diameters (IZD) with various anti-bacterial activities against the selected gram-positive and gram-negative bacteria. In addition, the rate of bis-(4-nitrophenyl) phosphate hydrolysis was measured at different temperatures, different pH values and different concentrations. The rates for the eight complexes were in the following order: complex 4 > 2 > 5 > 8 > 7 > 6 > 3 > 1. KEYWORDS anti-bacterial activity, bioactive nitrogen based ligands, bis-(4-nitrophenyl) phosphate, furosemide, zinc(II) complexes

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“…2,2-bipyridine have widely used as a chelating donor site during such bridging ligand because its robust redox stability and relative ease of functionalization [2] .Mixed ligand which contain 2,2-bipyridine and other bidentate ligand are antineoplastic agents ,these compounds exhibit cytotoxicity, antitumor effect and genotoxicity also have been bactericidal, bacteriostatic toward many grampositive bacteria but they are ineffective against gram-negative organism [3][4] . Generally the organosilane is active at both end ,R is amino group(NH 2 ), mercapto (SH), or isocyanato (NCO).This functionality reacted with other functional groups in industrial or biomolecule for example peptides or oligonucleotides [5][6][7] .While the other end consist of alkoxy silane.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of mixed- ligand complexes containing 2,2-Bipyridine and 3-aminopropyltriethoxysilane

Mihsen

Shareef

2018

J. Phys.: Conf. Ser.

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Pharmacological Activity of a Few Transition Metal Complexes: A Short Review

Cited by 75 publications

References 173 publications

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

Synthesis, Structures and Various Biological Applications of New Zn(II) Complexes Having Different Coordination Modes Controlled by the Drug Furosemide in Presence of Bioactive Nitrogen Based Ligands

Synthesis, characterization of mixed- ligand complexes containing 2,2-Bipyridine and 3-aminopropyltriethoxysilane

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