Pharmacological Effects of Gardenia erubescens in Mice, Rats and Cats

Hussain, Mahrukh; Sokomba, Elijah; Shok, M.

doi:10.3109/13880209109082857

Cited by 20 publications

(12 citation statements)

References 3 publications

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“…The bark is rich in triterpene saponins, triterpenoids and sterols [ 37 ]. The leaves are used for the treatment of digestive parasites in small ruminants [ 78 ] and the bark of the trunk has analgesic and diuretic activity [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso

et al. 2016

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Background: Obesity is a global epidemic that affects both developed and developing countries. According to World Health Organization (WHO), in 2014, over 1.9 billion adults were overweight. Burkina Faso, like other countries, faces the problem of obesity, with a prevalence of 7.3%. The main cause is excessive intake of caloric foods combined with low physical activity, although genetic, endocrine and environmental influences (pollution) can sometimes be predisposing factors. This metabolic imbalance often leads to multiple pathologies (heart failure, Type II diabetes, cancers, etc.). Drugs have been developed for the treatment of these diseases; but in addition to having many side effects, locally these products are not economically accessible to the majority of the population. Burkina Faso, like the other countries bordering the Sahara, has often been confronted in the past with periods of famine during which populations have generally used anorectic plants to regulate their food needs. This traditional ethnobotanical knowledge has not been previously investigated. An ethnobotanical survey was conducted in Burkina Faso in the provinces of Seno (North) and Nayala (Northwest) to list the plants used by local people as an anorectic and/or fort weight loss. Methods: The survey, conducted in the two provinces concerned traditional healers, herbalists, hunters, nomads and resourceful people with knowledge of plants. It was conducted over a period of two months and data were collected following a structured interview with the respondents. The approach was based on dialogue in the language of choice of the respondent and the use of a questionnaire. The data have been structured and then statistically analyzed. Results: The fifty-five (55) respondents of the survey were aged between 40 and 80 years. Sixty-one (61) plant species, belonging to thirty-one (31) families were listed as appetite suppressants and/or for their anti-obesity properties. The main families of plants are Mimosaceae, Rubiaceae, Asclepiadaceae and Cesalpiniaceae. Fruits are the most used part of the plant organs. Consumption in the raw state or as a decoction are the two main forms of preparation. Conclusion: The great diversity of plants cited by informants demonstrates the existence of rich local knowledge to address obesity in Burkina Faso. Evaluation of the biochemical activity of the extracts of the most cited species could allow the development of a phytomedicine economically accessible to the majority of the population. This could allow for the preservation of biodiversity in this region which is weakened by climate change because some of the species cited are in fragile state or are threatened with extinction.

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso

et al. 2016

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“…Some species are used as a febrifuge 4 and a larvicide, 5 as well as for the treatment of headaches, 6 asthma 7 and malaria. 8 Extracts of various species exhibiting antiimplantation and abortifacient effects, 9 anti-ulcer, 10 antibacterial, 11 diuretic, 12 analgesic, 12 hypertensive, 12 and larvicidal activity 13 have been previously reported. Our investigations of G. coronaria and G. sootepensis 14 led to the isolation of four ring-A seco-cycloartanes, and the work on G. obtusifolia 15 yielded one ring-A seco-cycloartane, two cycloartanes and five flavones.…”

Section: Introductionmentioning

confidence: 98%

Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera

et al. 2004

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“…ex Kurz (also known as Khammok noi), a medicinal plant that is used as an antiulcer (Takase et al, 1989), antibacterial (Laurens et al, 1985), analgesic, antidiuretic, and hypotensive agent (Hussain et al, 1991). A pentamethoxyflavone isolated from this plant, 5, 6,7,8,, has been shown to exhibit activity against HIV and against various mammalian tumor cell lines (Tuchinda et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

et al. 2010

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Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3Ј-dihydroxy-3,6,7,8,4Ј-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-B (NF-B) pathway is linked to inflammation and tumorigenesis, we investigated the effect of PMF on this pathway. We found that PMF suppressed NF-B activation induced by inflammatory agents, tumor promoters, and carcinogens. This suppression was not specific to the cell type. Although PMF did not directly modify the ability of NF-〉 proteins to bind to DNA, it inhibited IB␣ (inhibitory subunit of NF-B) kinase, leading to suppression of phosphorylation and degradation of IB␣, and suppressed consequent p65 nuclear translocation, thus abrogating NF-B-dependent reporter gene expression.Suppression of the NF-B cell signaling pathway by the flavone led to the inhibition of expression of NF-B-regulated gene products that mediate inflammation (cyclooxygenase-2), survival (XIAP, survivin, Bcl-xL, and cFLIP), proliferation (cyclin D1), invasion (matrix metalloproteinase-9), and angiogenesis (vascular endothelial growth factor). Suppression of antiapoptotic gene products by PMF correlated with the enhancement of apoptosis induced by tumor necrosis factor-␣ and the chemotherapeutic agents cisplatin, paclitaxel, and 5-flurouracil. Overall, our results indicate that PMF suppresses the activation of NF-B and NF-B-regulated gene expression, leading to the enhancement of apoptosis. This is the first report to demonstrate that this novel flavone has anti-inflammatory and anticancer effects by targeting the IKK complex.

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Pharmacological Effects of Gardenia erubescens in Mice, Rats and Cats

Cited by 20 publications

References 3 publications

Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso

Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso

Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

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