Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Sakai, Masashi; Yamatoya, Hideyuki; Kudo, Satoshi

doi:10.3177/jnsv.42.47

Cited by 37 publications

(22 citation statements)

References 14 publications

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“…Even though the acyl-groups of Soy-PS are quite different from that of BC-PS, studies using drug-induced amnesic and aged rodents have suggested that the effects of Soy-PS on cognitive function are identical to that of BC-PS [13–16]. …”

Section: Introductionmentioning

confidence: 99%

Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Kato-Kataoka

Sakai

Ebina

et al. 2010

J. Clin. Biochem. Nutr.

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Soybean-derived phosphatidylserine (Soy-PS) is a phosphatidylserine made from soybean lecithin by enzymatic reaction with L-serine. A double-blind, randomized controlled study was conducted to investigate the effects of Soy-PS on the cognitive functions of the elderly Japanese subjects with memory complaints. Seventy-eight elderly people with mild cognitive impairment (50–69 years old) were randomly allocated to take Soy-PS (100 mg, 300 mg/day) or placebo for 6 months. As a result, there was no difference in blood markers and vital signs during Soy-PS treatment and any side effect caused by Soy-PS treatment was not observed. Neuropsychological test scores were similarly increased in all groups including placebo group. However, in the subjects with relatively low score at baseline, the memory scores in PS treated groups were significantly increased against the baseline, while those of placebo group remained unchanged. And the memory improvements in Soy-PS-treated groups were mostly attributed to the increase in delayed verbal recall, a memory ability attenuated in the earliest stage of dementia. In conclusion, Soy-PS used in this study is considered as safety food ingredient and 6 months of Soy-PS supplementation could improve the memory functions of the elderly with memory complaints.

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Section: Introductionmentioning

confidence: 99%

Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Kato-Kataoka

Sakai

Ebina

et al. 2010

J. Clin. Biochem. Nutr.

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“…Clinical investigations have also shown that B-PS treatment can improve Alzheimer's disease (AD) and related cognitive disorders (8,9). Sakai et al (10) prepared soybean leci thin transphosphatidylated phosphatidylserine (SB-tPS) from soybean phosphatidylcholine by transphosphati dylation using phospholipase D, and they found that the intravenous or intraperitoneal administration of SB-tPS increases brain glucose concentrations in mice and antagonizes amnesic effects of scopolamine (SCP) in rats, as did B-PS.…”

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confidence: 99%

“…SB-tPS was prepared from soybean phosphatidyl choline (PC80TM; Croklaan b.v., Wormerveer, Holland) as reported in a previous paper (10). SCP, CYH and THA were obtained from Sigma Chemicals (St. Louis, MO, USA).…”

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confidence: 99%

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Furushiro

Shishido

Sakai

et al. 1997

Japanese Journal of Pharmacology

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ABSTRACT-Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cyclohex imide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

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“…SB-tPS was prepared from soybean phosphatidylcholine and L-serine by transphosphatidylation using phospholipase D as reported previously (8). SB-tPS emulsified by sonication in isotonic saline was orally administered (50 mg / kg) with a probe according to each experimental schedule.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Learning of Normal Adult Rodents by Repeated Oral Administration of Soybean Transphosphatidylated Phosphatidylserine

Kataoka-Kato¹,

Ukai²,

Sakai³

et al. 2005

J Pharmacol Sci

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Abstract. Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) is already known to improve the learning ability of aged or drug-induced amnesic rodents. In this study, its effect on normal adult rodents was evaluated using several learning tasks. Firstly, three behavioral tests (open-field, Y-maze, and active avoidance test) were consecutively carried out after the daily oral administration of SB-tPS (50 mg / kg per day, for 34 days). Repeated oral administration of SB-tPS did not affect either exploratory behavior in the open-field test or spontaneous alternation behavior in the Y-maze test, while mice pretreated with SB-tPS showed significant enhancement of conditioned avoidance response. Secondly, the brightness discrimination test was used to evaluate the effect of SB-tPS on learning ability. The daily oral administration of SB-tPS (50 mg / kg per day, for 27 days) to normal rats significantly increased the correct response ratio in the brightness discrimination test. Finally, to elucidate the necessity of SB-tPS pretreatment, another active avoidance test was carried out, and no enhancement of conditioned avoidance response was observed in non-pretreated mice. These results suggest that repeated administration of SB-tPS could enhance the learning ability of normal adult rodents as those of aged ones.

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Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Cited by 37 publications

References 14 publications

Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Enhanced Learning of Normal Adult Rodents by Repeated Oral Administration of Soybean Transphosphatidylated Phosphatidylserine

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