Pharmacological evaluation of sedative–hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins

Liu, Zhen; Gao, Wenyuan; Man, Shuli; Wang, Jieyin; Li, Nan; Yin, Shuangshuang; Wu, Shanshan; Liu, Changxiao

doi:10.1016/j.jep.2012.08.027

Cited by 33 publications

(20 citation statements)

References 28 publications

(28 reference statements)

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“…However, regarding its hypotoxic and gastric stimulus side effects [9], drug combination screening was carried out. Subsequently, water extract of turmeric (T) showed a well synergistic effect on RPS's antitumor activity.…”

Section: Discussionmentioning

confidence: 99%

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Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice

Man

Chai

Qiu

et al. 2015

Pathology - Research and Practice

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Section: Discussionmentioning

confidence: 99%

“…Rhizoma paridis saponins (RPS), extracted from Paris polyphylla, exhibited good antitumor effects in our previous research [15]. However, low bioavailability [33] and side effects, such as hypotoxicity and gastric stimulus, limited its application [9].…”

Section: Introductionmentioning

confidence: 99%

Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice

Man

Chai

Qiu

et al. 2015

Pathology - Research and Practice

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“…RPS as effective and toxic nature produces in many famous traditional Chinese medicines exhibited anticancer, antibacterial, and anti‐inflammatory effects (Man et al, ). However, hypotoxicity of RPS limited their utility (Liu et al, ). Curcumin, a phenolic natural product isolated from turmeric, was well known to exhibit antioxidant, antitumor, anti‐inflammatory, and gene‐regulatory activity (Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Rhizoma Paridis saponins (RPS) are the major active compounds in many traditional Chinese medicines (Man et al, ), such as Yunnan‐Bai Yao, Yifei‐Kangliu Yin, and so forth. In traditional clinical usage, excessive ingestion of RPS could cause side effects such as nausea, vomiting, diarrhea, gastric stimulus, and even heart palpitations and convulsions (Liu et al, ). In our previous research, combination of Rhizoma Curcuma longa (turmeric) with RPS not only overcame the low oral bioavailability of RPS but also improved their anticancer effect (Liu et al, ; Man et al, ).…”

Section: Introductionmentioning

confidence: 99%

Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats

Man

Liu

et al. 2015

Environ. Toxicol.

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Rhizoma Paridis saponins (RPS), as steroid saponins, are the main components in Paris polyphylla. Curcumin (diferuloylmethane) is the most important component in the spice turmeric. In our previous research, RPS exhibited side effects such as nausea, vomiting, diarrhea, and so forth. Combination with curcumin not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumor cells and enhanced their anticancer effect. This study evaluated subchronic toxicity of 45 dietary of RPS and curcumin on histopathology, biochemistry, and antioxidant index. As a result, RPS-treatment caused a slight liver injury (the elevation of serum AST, alkaline phosphatase (AKP), alanine transaminase (ALT), and gamma glutamyl transpeptidase (γ-GT), histopathological changes in liver section), oxidative stress (the enhancement of reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-2-deoxyguanosine (8-OHdG), separation of thioredoxin (Trx) and thioredoxin-interacting protein (TXNIP), but enhancement of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and nuclear factor-regulated factor 2 (Nrf2)), and inflammation (up-regulation of cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and nuclear factor kappaB (NF-κB)). However, these changes were alleviated through co-treatment with curcumin. In conclusion, our work provided useful data for further research and new drug exploration of RPS and curcumin. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1935-1943, 2016.

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“…It appeared with the name ''ZaoXiu'', and many wellknown formulary Chinese Medicines contain Rhizoma Paridis, such as Yunnan Baiyao Powder and Gongxuening Capsules produced by Yunnan Baiyao Group Ltd. Co. (Yunnan, China), Loulian Capsules (Tonghua Wantong Pharmaceutical Ltd. Co., Tonghua, China), Jidesheng Sheyao Tablet (Nantong Jinghua Pharmaceutical Ltd. Co., Nantong, China). Rhizoma Paridis saponins (RPS) (Man et al, 2009a), as steroidal saponins, are the main and the active components in PPY (Liu et al, 2012;Qin et al, 2012;Zhang et al, 2010). They recently attracted particular interests because modern pharmacology research indicated these steroidal saponins appeared to exhibit a variety of biological activities, such as antitumor (Man et al, 2009b(Man et al, , 2011a, antifungal activity (Deng et al, 2008), inhibitory activities against abnormal uterine bleeding (Fu et al, 2008) and anthelmintic activity (Wang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Preparative separation and purification of steroidal saponins inParis polyphyllavar.yunnanensisby macroporous adsorption resins

Liu

Wang

Gao

et al. 2013

Pharmaceutical Biology

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Context: Saponins are active compounds in natural products. Many researchers have tried to find the method for knowing their concentration in herbs. Some methods, such as solid-liquid extraction and solvent extraction, have been developed. However, the extraction methods of the steroidal saponins from Paris polyphylla Smith var. yunnanensis (Liliaceae) are not fully researched. Objective: To establish a simple extraction method for the separation of steroidal saponins from the rhizomes of P. polyphylla Smith var. yunnanensis. Materials and methods: Macroporous adsorption resins were used for the separation of steroidal saponins. To select the most suitable resins, seven kinds of macroporous resins were selected in this study. The static adsorption and desorption tests on macroporous resins were determined. Also, we optimized the temperature and the ethanol concentration in the extraction method by the contents of five kinds of saponins. Then, we compared the extraction method with two other methods. Results: D101 resin demonstrated the best adsorption and desorption properties for steroidal saponins. Its adsorption data fits best to the Freundlich adsorption model. The contents of steroidal saponins in the product were 4.83-fold increased with recovery yields of 85.47%. Discussion and conclusion: The process achieved simple and effective enrichment and separation for steroidal saponins. The method provides a scientific basis for large-scale preparation of steroidal saponins from the Rhizoma Paridis and other plants.

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Pharmacological evaluation of sedative–hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins

Cited by 33 publications

References 28 publications

Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice

Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice

Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats

Preparative separation and purification of steroidal saponins inParis polyphyllavar.yunnanensisby macroporous adsorption resins

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