Pharmacological Evaluation of Zafirlukast in Experimentally Induced Global Cerebral Ischemia/Reperfusion Injury in Mice

Nayak, Bipin Kumar; Kumar, Arun; Kothiyal, Preeti

doi:10.22159/ijpps.2018v10i2.21633

Cited by 3 publications

(2 citation statements)

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“…Numerous methods have been used for the determination of paracetamol in pharmaceutical formulations and biological fluids including UV‐vis spectrophotometry, fluorimetry, near infrared transmittance spectroscopy and chromatography with several detectors [9–13] . The quantification of PAR from in vitro dissolution assays of commercially available formulations has been carried out with spectrophotometric methods [14–16] …”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12][13] The quantification of PAR from in vitro dissolution assays of commercially available formulations has been carried out with spectrophotometric methods. [14][15][16] Electrochemical drug determination has attracted great attention because electrochemical methods are low cost, highly sensitive, easy to use, and portable when needed. PAR is an electroactive compound.…”

Section: Introductionmentioning

confidence: 99%

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Carbon Nanotube Modified Glassy Carbon Electrodes for on‐line and off‐line in vitro Therapeutic Equivalence Assessment of Paracetamol Tablets

Cumsille‐Escandar,

Yáñez,

Álvarez‐Lueje

2024

ChemistrySelect

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In vitro bioequivalence assessment of paracetamol tablets was carried out by differential pulse voltammetry (DPV) and amperometry using a multiwalled carbon nanotube modified glassy carbon electrode (GCE/MWCNT). For the DPV developed method, samples were collected from the USP paddle apparatus, while amperometric measurements were carried out in situ. The DPV method was validated in three supporting electrolytes (per in vitro bioequivalence guidelines) by measuring the recovery from standard solutions and paracetamol tablet solutions, while precision was evaluated through the RSD (n=6). In HCl pH 1.2 solution the LOD and LOQ were 48 nM and 160 nM, respectively and the linear range was between 0.18–2.2 μM. In acetate buffer pH 4.5 the LOD and LOQ were 15 nM and 51 nM, respectively and the linear range was between 88 nM–880 nM. And in phosphate buffer pH 6.8 the LOD and LOQ were 4.6 nM and 15 nM, respectively and the linear range was between 88 nM–880 nM. Recovery values were between 95 and 105 % and precision values were less than 5 %. Results showed that both methods were effectively applied for the analysis of samples.

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Section: Introductionmentioning

confidence: 99%