Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease

Li, Zhou Peng; Kong, Dehui; Liu, Yongsheng; Li, Mingkai

doi:10.1016/j.gendis.2021.03.007

Cited by 43 publications

(24 citation statements)

References 95 publications

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“…However, given the diversity of the chemical structure of coumarin derivatives, these compounds affected the different life cycle stages of virus. In HIV, tricyclic coumarin GUT-70 blocked the attachment and fusion stage of HIV to the cellular wall or plasma membrane, whereas dipyranocoumarin (+)-calanolide A could inhibit the reverse transcription; coumarin dimmer analogs could inhibit the HIV integrase, and amide coumarin derivatives could affect the assembly of HIV ( Li et al, 2021 , april 20). Based on the structure of coumarin, we synthesized two major types of coumarin derivatives, dicoumarin and pyrone-coumarin.…”

Section: Discussionmentioning

confidence: 99%

Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT

Wang

Liu

et al. 2021

Front. Pharmacol.

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Hantaviruses are globally emerging zoonotic viruses that can cause hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe, which is primarily caused by Hantaan virus (HTNV) infection, results in profound morbidity and mortality. However, no specific treatment is available for this disease. Coumarin derivatives have been reported as antiviral molecules, while studies about the bioactivity of coumarin derivatives against HTNV infection are limited. To study the potential antiviral activity of coumarin derivatives, 126 coumarin derivatives are synthesized, and their inhibitory activity against HTNV is analyzed in vitro. Among these compounds, N6 inhibits HTNV with relatively high selectivity index at 10.9, and the viral titer of HTNV is reduced significantly after 5, 10, and 20 μM N6 treatments. Furthermore, the administration of N6 at the early stage of HTNV infection can inhibit the replication and production of infectious HTNV in host cell, this therapeutic efficacy is confirmed in HTNV-infected newborn mice at the early stage of infection. The molecular docking results show that N6 forms interactions with the key amino acid residues at its active site, and reveals several molecular interactions responsible for the observed affinity, and the treatment of N6 can inhibit the expression of p (Ser473)Akt and HTNV nucleocapsid protein significantly. As such, these observations demonstrate that coumarin derivative N6 might be used as a potential agent against HTNV infection.

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Section: Discussionmentioning

confidence: 99%

Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT

Wang

Liu

et al. 2021

Front. Pharmacol.

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“…Another in vitro assay indicated that essential oil treatment appreciably exhibited antibacterial activity against two S. aureus (ATCC 25923) and E. coli (ATCC 8739) with a minimum inhibitory cincentration (MIC) of 14.2 and 2.84 μl/ml, respectively (Acimovic, Pavlovic, et al, 2017a;Acimovica, Vetkovicb, et al, 2017b). Li, Kong, Liu, and Li (2021) et al, 2006). STW 5, exerted a spasmolytic effect on histamineinduced contractions in ex-vivo intestinal preparations and have been postulated that preparation was as effective as commercial preparations employed as a positive control in the study (Heinle et al, 2006).…”

Section: Anti-bacterial and Anti-viral Activity Of A Archangelicamentioning

confidence: 99%

“…Another in vitro assay indicated that essential oil treatment appreciably exhibited antibacterial activity against two S. aureus (ATCC 25923) and E. coli (ATCC 8739) with a minimum inhibitory cincentration (MIC) of 14.2 and 2.84 μl/ml, respectively (Acimovic, Pavlovic, et al, 2017a; Acimovica, Vetkovicb, et al, 2017b). Li, Kong, Liu, and Li (2021) have explored the antiviral potential of coumarin derivatives obtained from plant sources. The author proposed that natural coumarins have promising antiviral potential against human immunodeficiency virus (HIV), herpes simplex virus (HSV), Chikangunya, Enteroviurs, and Hepatitis virus.…”

Section: Anti‐bacterial and Anti‐viral Activity Of A Archangelicamentioning

confidence: 99%

“…The author proposed that natural coumarins have promising antiviral potential against human immunodeficiency virus (HIV), herpes simplex virus (HSV), Chikangunya, Enteroviurs, and Hepatitis virus. The authors have further suggested that structural modification in the coumarin scaffold can lead to the development of highly potent antiviral molecules against both RNA and DNA viruses (Li et al, 2021). Sahoo et al, 2021 have proposed various mechanisms, including inhibition of bacterial folate synthesis, bacterial DNA gyrase and topoisomerase among the chief mechanisms that confer anti‐bacterial activity to coumarin nucleus (Sahoo et al, 2021).…”

Section: Anti‐bacterial and Anti‐viral Activity Of A Archangelicamentioning

confidence: 99%

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Understanding the phytochemistry and molecular insights to the pharmacology of Angelica archangelica L. (garden angelica) and its bioactive components

Kaur

Bhatti

2021

Phytotherapy Research

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Plant-derived molecules have enduring usefulness in treating diseases, and herbal drugs have emerged as a vital component of global therapeutic demand. Angelica archangelica L. (A. archangelica), commonly known as garden angelica, is an aromatic food plant used in culinary procedures as a flavoring agent. In the traditional medicine system, it is regarded as an "Angel plant" due to its miraculous curative power. This review aims to provide a comprehensive summary of the plant's taxonomic profile, ethnopharmacology, Phytochemistry, and pharmacological activities. Various in vivo and in vitro experiments have validated that the plant possesses broad pharmacological potential. The biological activities attributed to the plant include anti-anxiety activity, anti-convulsant activity, cognition enhancer, antiviral activity, cholinesterase inhibitory potential, antiinflammatory activity, gastroprotective activity, and radioprotective activity. The beneficial effects of the plant are credited to its bioactive components, that is, coumarins and volatile oils. The review summarizes the pharmacological activities of crude extract and its bioactive fractions and has also explored their target-oriented effects. This review will be of value in undertaking further investigations on the plant with regard to exploring mechanism-based pharmacological approaches on A. archangelica.

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“…Coumarins can be called privileged heterocyclic compounds. They display a broad range of biological activities such as anti-viral, anti-microbial, anti-HIV, anti-malarial, and so on [ 173 , 174 ].…”

Section: O- Containing Heterocyclic Scaffolds For the Inhibi...mentioning

confidence: 99%