Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Fu, Yuhua; Chen, Ting-Hsu; Weng, Lebin; Huang, Liyue; Lai, Dong; Weng, Ching‐Feng

doi:10.1016/j.biopha.2021.111888

Cited by 132 publications

(78 citation statements)

References 107 publications

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“…The anti-inflammatory effect of curcumin is equally significant. Curcumin inhibits and regulates tissue production and secretions of pro-inflammatory cytokine, such as interleukins or tumor necrosis factor alpha (TNF-α) [ 17 ].…”

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

“…Curcumin and Curcuma longa extract inhibit the growth of microorganisms, both G(+) and G(-) bacteria, which often cause human infectious diseases. Curcumin is known to have an antiviral effect [ 17 ]; it also has been suggested as a potential treatment option for patients with COVID-19 [ 19 ]. Curcumin has an anti-diabetic effect through, for example, enhancing glucose uptake and improving pancreatic beta cell function.…”

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

“…Other activities of curcumin worth mentioning include immune modulation, cardiovascular protection, anti-pulmonary fibrosis, anti-chronic obstructive pulmonary disease and anti-dementia activity [ 17 ]. There is a growing scientific interest in curcumin’s therapeutic potential.…”

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

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Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in Curcuma longa L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.

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Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

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Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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“…The direct antioxidative activities of curcumin have been reported to be 2.5-fold stronger than those of vitamin C and are facilitated by the free radical scavenging functions of its phenolic hydroxyl groups. Curcumin also acts as an indirect antioxidant by increasing the synthesis of the antioxidant peptide glutathione, as well as the expression and activities of antioxidative enzymes, such as superoxide dismutase, catalase and glutathione peroxidase (reviewed in [ 2 , 3 , 4 ]).…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Activity of Curcumin on P-Glycoprotein and Its Uptake by and Efflux from LS180 Cells Is Not Affected by Its Galenic Formulation

2021

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The biological activities of curcumin in humans, including its antioxidative and anti-inflammatory functions, are limited by its naturally low bioavailability. Different formulation strategies have been developed, but the uptake of curcumin from these galenic formulations into and efflux from intestinal cells, which may be critical processes limiting bioavailability, have not been directly compared. Furthermore, little is known about their effect on P-glycoprotein activity, an important determinant of the pharmacokinetics of potentially co-administered drugs. P-glycoprotein activity was determined in LS180 cells, incubated with 30 or 60 µmol/L of curcumin in the form of seven different formulations or native curcuma extract for 1 h. All formulations inhibited P-glycoprotein activity at both concentrations. Curcumin uptake, after 1 h incubation of LS180 cells with the formulations (60 µmol/L), showed significant variability but no consistent effects. After 1 h pre-treatment with the formulations and further 8 h with curcumin-free medium, curcumin in cell culture supernatants, reflecting the efflux, differed between individual formulations, again without a clear effect. In conclusion, curcumin inhibits P-glycoprotein activity independently of its formulation. Its uptake by and efflux from intestinal cells was not significantly different between formulations, indicating that these processes are not important regulatory points for its bioavailability.

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“…Curcumin có các hoạt tính sinh học mạnh như kháng viêm, kháng khối u, kháng oxy hóa và kháng khuẩn [1], [2]. Trong môi trường acid và trung tính (pH = 3 -7), curcumin tồn tại ở dạng keto và hoạt động như một chất nhường proton, do đó, có chức năng quan trọng đối với hoạt tính kháng oxy hóa [3].…”

Section: đặT Vấn đềunclassified

Nghiên Cứu Tạo Nang Micro Curcumin Bằng Phương Pháp Tạo Gel Ion

Hùng¹,

Ngà²

2021

TNUJST

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Curcumin có nhiều hoạt tính sinh học mạnh như kháng oxy hóa, kháng khuẩn, kháng viêm, kháng khối u... Tuy nhiên, sinh khả dụng và độ hòa tan của curcumin thấp, tốc độ giải phóng nhanh, hấp thu kém do đặc tính ít tan trong nước. Để khắc phục các hạn chế của curcumin, phương pháp tạo gel ion đã được sử dụng trong nghiên cứu này, với sự kết hợp đồng thời của pectin, chất hoạt động bề mặt Solutol® HS 15 và ion canxi hóa trị 2, nhằm tạo ra viên nang curcumin có kích thước micro. Kết quả cho thấy, hiệu suất bào chế, hình thái và kích thước của nang micro curcumin bị thay đổi khi thay đổi lượng Solutol® HS 15. Hoạt tính kháng oxy hóa của nang micro curcumin có bổ sung Solutol® HS 15 với nồng độ từ 25% (w/v) thay đổi không đáng kể so với bột curcumin nguyên liệu. Từ đó, công thức thích hợp để bào chế nang micro curcumin đã được tối ưu và lựa chọn.

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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Cited by 132 publications

References 107 publications

Curcumin and Weight Loss: Does It Work?

Curcumin and Weight Loss: Does It Work?

The Inhibitory Activity of Curcumin on P-Glycoprotein and Its Uptake by and Efflux from LS180 Cells Is Not Affected by Its Galenic Formulation

Nghiên Cứu Tạo Nang Micro Curcumin Bằng Phương Pháp Tạo Gel Ion

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