Pharmacology of ocular allergy

Schultz, Beth Lillian

doi:10.1097/01.all.0000244801.79475.66

Cited by 22 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consequently, it was thought that the responsiveness in IP‐null mice inclined towards a Th2 response. There are some reports concerning the role of PGs in allergic inflammation by other researchers [20–24]. Taking this evidence together with our results, we postulate the existence of a balance mechanism of allergic inflammation regulated by arachidonate as shown in Fig.…”

Section: Role Of Prostaglandins In Allergic Inflammationsupporting

confidence: 86%

Possible role of prostaglandins in allergic inflammation

Nagai

Tanaka²,

Inagaki³

et al. 2007

Clin Exp All Rev

View full text Add to dashboard Cite

Summary Prostaglandins (PGs) and thromboxanes (TXs) are autacoids that exhibit a wide variety of actions in various cells and tissues. There is persuasive evidence that some PGs contribute to causing signs and symptoms of inflammation. In this study, we investigated the role of PGs and TXs in allergic airway inflammation by using a mouse model. When indomethacin was orally administered to allergic mice, the production of T‐helper type 2 cytokines, IgE antibody, and airway eosinophils and airway responsiveness to acetylcholine were accelerated. We next focused on the role of each PG by using mice lacking specific PG receptor genes. We examined the effects of depletion of PGD2 receptor (DP), PGE2 receptor (EP1, EP3, and EP4), PGI2 receptor (IP), and TxA2 receptor (TP) genes on the development of allergic inflammation in mice. As a result, allergic inflammation in the airway was accelerated in EP3 and IP gene knockout mice whereas inflammation was clearly suppressed in DP and TP gene‐deficient mice. These data suggest that PGE2 and PGI2 might have a suppressive role whereas PGD2 and TxA2 have pathological roles in the development of allergic airway inflammation.

show abstract

Section: Role Of Prostaglandins In Allergic Inflammationsupporting

confidence: 86%

Possible role of prostaglandins in allergic inflammation

Nagai

Tanaka²,

Inagaki³

et al. 2007

Clin Exp All Rev

View full text Add to dashboard Cite

show abstract

“…A hallmark of conjunctival inflammation that occurs in ocular allergy is an influx of mast cells and neutrophils that release histamine, leukotrienes, proteases, PGs, and cytokines (32, 33). Similarly, in dry eye disease, inflammation of the ocular surface includes cytokine production and infiltration of T cells and neutrophils (34).…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation

Dartt

Hodges

et al. 2011

The Journal of Immunology

112

134

View full text Add to dashboard Cite

The conjunctiva is a mucous membrane that covers the sclera and lines the inside of the eyelids. Throughout the conjunctiva are goblet cells that secrete mucins to protect the eye. Chronic inflammatory diseases such as allergic conjunctivitis and early dry eye lead to increased goblet cell mucin secretion into tears and ocular surface disease. The purpose of this study was to determine the actions of the inflammatory mediators, the leukotrienes and the proresolution resolvins, on secretion from cultured rat and human conjunctival goblet cells. We found that both cysteinyl leukotriene (CysLT) receptors, CysLT1 and CysLT2, were present in rat conjunctiva and in rat and human cultured conjunctival goblet cells. All leukotrienes LTB4, LTC4, LTD4, and LTE4, as well as PGD2, stimulated goblet cell secretion in rat goblet cells. LTD4 and LTE4 increased the intracellular Ca2+ concentration ([Ca2+]i), and LTD4 activated ERK1/2. The CysLT1 receptor antagonist MK571 significantly decreased LTD4-stimulated rat goblet cell secretion and the increase in [Ca2+]i. Resolvins D1 (RvD1) and E1 (RvE1) completely reduced LTD4-stimulated goblet cell secretion in cultured rat goblet cells. LTD4-induced secretion from human goblet cells was blocked by RvD1. RvD1 and RvE1 prevented LTD4- and LTE4-stimulated increases in [Ca2+]i, as well as LTD4 activation of ERK1/2. We conclude that cysteinyl leukotrienes stimulate conjunctival goblet cell mucous secretion with LTD4 using the CysLT1 receptor. Stimulated secretion is terminated by preventing the increase in [Ca2+]i and activation of ERK1/2 by RvD1 and RvE1.

show abstract

“…2 The predominant treatments of allergic conjunctivitis are directed at the histamine H 1 receptor and include oral antihistamines that target H 1 receptors and topical dual-action agents emedastine, epinastine, and ketotifen that are directed at H 1 , H 2 , and other targets. 12 In the present study the authors determined the effect of histamine and its receptors on goblet cell secretion. The findings showed that histamine using all four histamine receptor subtypes (H 1 -H 4 ) stimulated goblet cell secretion.…”

mentioning

confidence: 96%

Role of Histamine and Its Receptor Subtypes in Stimulation of Conjunctival Goblet Cell Secretion

Hayashi¹,

Hayashi

et al. 2012

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Rat and human conjunctival goblet cells are a direct target of histamine, which induces secretion. All four histamine receptors are present in rat and human conjunctiva and are active in rat conjunctival goblet cells. These findings suggest that all four histamine receptor subtypes are important for conjunctival goblet cell secretion. Blockage of histamine receptor subtypes could prevent the excess mucus production associated with ocular allergy.

show abstract

Pharmacology of ocular allergy

Cited by 22 publications

References 52 publications

Possible role of prostaglandins in allergic inflammation

Possible role of prostaglandins in allergic inflammation

Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation

Role of Histamine and Its Receptor Subtypes in Stimulation of Conjunctival Goblet Cell Secretion

Contact Info

Product

Resources

About