Pharmacotherapy of Peptic Ulcer Disease and Latest Research

Abstract

Peptic ulcers have unquestionably been a disease of the twentieth century. Epidemiological data for this disease and its complications have shown striking variation in incidence and prevalence. Various drugs have been used to treat peptic ulcer disease like proton-pump inhibitors, histamine (H2) receptor antagonists, prostaglandin analogues and sucralfate. Because these drugs are complex, expensive and toxic, efforts have been constantly made to find a suitable, palliative and curative agent for the treatment of peptic ulcer disease from natural products of plant and animal origin. Recently, antioxidants are being used to treat peptic ulcer disease. Antioxidants help in scavenging the free radicals and controlling the oxidative stress responsible for the progression of peptic ulcer.

Phytochemical Screening, Antioxidant, Antiulcer, Anti-Inflammatory and Analgesic Activity of the Aqueous Extract of Angelica archangelica

“…The average age of onset of ulcers is 65 (exceptional before 40 years) (Karila-Cohen et al, 2005). The aetiologies of gastric ulcer were multiple: factors hereditary in 15 to 50% with a predominance of blood groups A, syndromes genetic (multiple endocrine neoplasias type 1), psychological factors (stress, stay in intensive care), environmental factors (tobacco, alcohol, coffee) and medication (salicylates, NSAIDs and AIS) (Mustafa et al, 2015;Ommurugan and Rao, 2019). It is currently believed that Helicobacter pylori is present with a prevalence of more than 60% in patients with a gastric ulcer and more than 70% in those with antral gastritis.…”

“…Its treatment is sometimes difficult, according to the depth of the ulcer. Treatment with modern medicine is sometimes expensive, which constitutes a handicap for the patient (Barkun and Leontiadis, 2010;Ommurugan and Rao, 2019). For those who have the means to do it, they develop sometimes a reluctance towards the disease, which is added to the side effects of medications.…”