Phase Angle, an Alternative Physiological Tool to Assess Wound Treatment in Chronic Nonhealing Wounds

Abstract

BACKGROUND: This exploratory study was conducted in an effort to demonstrate that bioelectrical impedance analysis (BIA) phase angle measurement is a novel tool for monitoring the effectiveness of a wound care regimen at a regional level and is valuable in comparing that status with the overall metabolic health of the patient. Isolating and measuring the extent to which nutritional supplementation contributes to the healing process is difficult and confounded by the many treatment modalities patients undergo.OBJECTIVE: The authors conducted a limited exploratory study to determine whether regional phase angle measurements accurately reflected the status of chronic nonhealing wounds. This information would potentially provide the ability to quantitatively evaluate of the role of nutritional supplementation in wounds of varying etiologies by comparing regional BIA phase angle measurement with overall BIA phase angle measurement.METHODS: Eleven patients with wounds of varying etiologies were selected to participate. Each patient underwent a treatment regimen specific to his or her condition, and all patients were given JUVEN Ò nutritional supplement.RESULTS AND CONCLUSION: In all patients, the BIA phase angle measurement mirrored the health of the wound and provided an accurate tool for assessing the regional tissue health, a valuable insight in measuring the effectiveness of a systemic treatment.

Impedance sensing device enables early detection of pressure ulcers in vivo

“…For example, in vitro impedance measurements have been shown to detect cell proliferation and cell-drug interaction 12 , quantify biomass in suspensions 11,13 and create two-dimensional images of cell migration 14 . Much of this work utilizes the electrical 'signature' of the cell membrane: a well-functioning cell membrane is relatively impermeable and thus behaves like a capacitor in the presence of electric current [9][10][11]13,15 . Cell damage or death results in a loss of membrane structure and integrity, allowing ions and current to pass through the membrane.…”

Ângulo de fase para avaliar risco ou cicatrização de lesões: revisão sistemática

“…After reading the full texts, 5 studies were included for the qualitative synthesis, as shown in Figure 1. In relation to the outcomes, four evaluated wound healing (E1, E2, E3, E4) (15)(16)(17)(18) .…”

“…Study E1 tested PA as an alternative physiological tool to evaluate the treatment of chronic non-healing wounds (15) . In all the patients, the measurement of the phase angle of EBI was effective, as it reflected the intrinsic state of the wound and provided an accurate tool to assess the regional health of the tissues, In Study E2, no association between PA and wound healing was demonstrated (16) .…”

“…Chart 3 shows the risk of bias by using the JBI's critical analysis tools. All the studies presented items that were not attended and/or that were not clearly described in the studies, and Study E4 obtained the highest percentage of positive answers (87.5%) and Study E1, the lowest percentage (66.7%) (15)(16)(17)(18) .…”

Prospective exploration of the effect of adiposity and associated microbial factors on healing and progression of diabetic foot ulcers in Tanzania: study protocol of a longitudinal cohort study

“…Indeed in patients with T2DM with advanced foot ulcers, a high protein diet resulted in a significant recreation of LBM and substantial improvement in DFUs 31 36 42. Several other studies have demonstrated comparable improvements in wound healing with restoration of normal body composition 43–46. In most of those studies however, the main focus had been LBM and not adiposity.…”