Phase-dependent phase shift of methamphetamine-induced circadian rhythm by haloperidol in SCN-lesioned rats

Honma, Sato; Honma, Ken‐ichi

doi:10.1016/0006-8993(95)00027-n

Cited by 31 publications

(14 citation statements)

References 16 publications

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“…These 5-HT enhancing effects of TSD and LT could also explain the sleep reduction in responders, a phenomenon observed in the present study, because pharmacogenetic studies have showed that human homozygotes for the long variants of the serotonin promoter gene polymorphism, which respond better to both antidepressant TSD and serotonergic drugs (Benedetti et al, 1999), also reduce their sleep and increase their nighttime locomotor activity when treated with SSRIs (Putzhammer et al, 2005). Moreover, the DA-enhancing effects of TSD could contribute to the observed effects, because DA can entrain the activity-rest rhythm (Fertl et al, 1993;Honma & Honma, 1995), regulate the generation of sleep-wake states (Dzirasa et al, 2007), and exert complex effects on the physiological functions of sleep and dream mentation (Dahan et al, 2006). Other neurobiological mechanisms could involve the arousal-enhancing transmitter norepinephrine, which is markedly enhanced by TSD (Conti et al, 2007), or the expression of several immediate-early genes and transcription factors, genes related to energy metabolism, growth factors, adhesion molecules, chaperones, and heat shock proteins, vesicle-and synapserelated genes, neurotransmitter and hormone receptors, neurotransmitter transporters, and enzymes, which are enhanced by TSD (Cirelli & Tononi, 2000).…”

Section: Discussionmentioning

confidence: 65%

Phase Advance Is an Actimetric Correlate of Antidepressant Response to Sleep Deprivation and Light Therapy in Bipolar Depression

Benedetti

Dallaspezia

Fulgosi

et al. 2007

Chronobiology International

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The combination of total sleep deprivation (TSD) and light therapy (LT) in bipolar depression causes rapid antidepressant effects, and its mechanism of action has been hypothesized to involve the enhancement of all of the monoaminergic systems targeted by antidepressant drugs (serotonin, dopamine, norepinephrine). It is still unknown if the clinical effects are paralleled by changes in biological rhythms. In a before/after design of a study of biological correlates of response, 39 inpatients affected by Type I Bipolar Disorder whose current depressive episode was without psychotic features were treated for one week with repeated TSD combined with morning LT. Wrist actigraphy was recorded throughout the study. Two-thirds of the patients responded to treatment (50% reduction in Hamilton Depression score). Responders showed an increase in daytime activity, phase-advance of the activity-rest rhythm of 57 min compared to the pre-treatment baseline, and reduced nighttime sleep. Non-responders did not show significant changes in the parameters of their activity-rest rhythm. Phase advance of the activity-rest rhythm is an actimetric correlate of the antidepressant response to TSD and LT in bipolar depression. Results are consistent with the known effects of sleep-wake manipulations and neurotransmitter function on the suprachiasmatic nucleus.

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Section: Discussionmentioning

confidence: 65%

Phase Advance Is an Actimetric Correlate of Antidepressant Response to Sleep Deprivation and Light Therapy in Bipolar Depression

Benedetti

Dallaspezia

Fulgosi

et al. 2007

Chronobiology International

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“…We demonstrated in previous studies that MAP coadministered with the D 1 /D 2 receptor antagonist, haloperidol, the D 1 receptor antagonist, SCH23390, or the NMDA receptor antagonist, MK‐801, inhibited the development of MAP‐induced anticipatory locomotor activity and mPer1 gene expression in the striatum (Shibata et al ., 1995; Nikaido et al ., 2001). In addition, Honma & Honma (1995) reported that the free‐running rhythm induced by ingested MAP was reset by haloperidol. Taken together, these results suggest that both D 1 and NMDA receptor subtypes are involved in the appearance of MAP‐associated behavioural rhythms and mPer gene expression.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse

Iijima

Nikaido

Akiyama

et al. 2002

Eur J of Neuroscience

112

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While the suprachiasmatic nucleus (SCN) coordinates the majority of daily rhythms, some circadian patterns of expression are controlled from outside of the SCN. These include responses to daily methamphetamine (MAP) injection, or daily restricted feeding. The mechanisms underlying these SCN‐independent circadian rhythms are unknown. A circadian oscillation in the expression of mPer1 and/or mPer2, mouse period, in the SCN is considered necessary to generate an SCN‐dependent circadian rhythm. Therefore, in this experiment, we examined the association between mPer gene expression and the MAP‐induced, SCN‐independent circadian rhythm. Acute injection of MAP caused an elevation of mPer1, mBmal1, and mNpas2 gene expression in the striatum and mPer1 in the liver. Daily MAP injection at a fixed time for 6 days shifted the rhythmic mPer1 and mPer2 expression in the striatum from a nocturnal to a diurnal rhythm, but failed to affect that in the SCN. Although lesion of the SCN ‘flattened’mPer gene oscillation in the striatum and liver, daily MAP injection caused both behavioural and mPer gene expression rhythms. Daily MAP injection at variable injection intervals (12–36 h) for 6 days, however, failed to produce mPer gene rhythm in the striatum. Daily repeated MAP signals may strengthen the oscillatory force of SCN‐independent circadian behavioural and molecular rhythms. The present results suggest that daily oscillation of mPer genes outside the SCN is closely associated with the regulation of SCN‐independent rhythms. Thus, the present experiment highlights strongly the important role of clock gene expression, in the brain, that underlies the circadian behavioural rhythm.

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“…Injections of Haloperidol, which is a dopamine antagonist with some sedative effects, cause phase-shifts of the MAPinduced circadian activity rhythms in SCN-lesioned arrhythmic female rats. In contrast, Pentobarbital or ether, which also has similar sedative effects, do not cause phase-shifts (Honma and Honma 1995). This suggests that the dopaminergic system is either involved in the entraining pathway of MASCO or in MASCO itself.…”

Section: Localization Of Mascomentioning

confidence: 91%

“…Both dopamine and serotonin systems seem to be involved in the circadian effects of MAP (Honma and Honma 1995). Injections of Haloperidol, which is a dopamine antagonist with some sedative effects, cause phase-shifts of the MAPinduced circadian activity rhythms in SCN-lesioned arrhythmic female rats.…”

Section: Localization Of Mascomentioning

confidence: 99%

“…However, the comparison between intact and SCNX C3H mice suggests that the presence of SCN inhibits MASCO or its output. Although, involvement of dopamine, serotonin and noradrenaline in the effects MASCO were suggested (Honma and Honma 1995), it has never been fully tested. One way to address this question would be to apply repeated injections of high doses of MAP to deplete monoamines in the brain and then apply MAP chronically to test whether MAP induced increase in activity, alpha or period length can be observed.…”

Section: (Nxcj IImentioning

confidence: 99%

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Effects of Methamphetamine on Circadian Rhythms of Mice

Tataroglu

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The circadian system allows an organism to anticipate rhythmic changes in the external conditions and thereby increases its fitness. In rodents, the circadian clock resides in a pair of nuclei called the suprachiasmatic nuclei (SCN) which regulates rhythms of locomotor behavior, body temperature and some other physiological variables. However, this hierarchical organization of the circadian system is challenged by the discovery of two SCN-independent major oscillators; a feeding-entrainable oscillator (FEO) and a methamphetamine-sensitive circadian oscillator (MASCO). The presence of SCN, FEO and MASCO suggests a central multi-oscillatory organization of the circadian system in rodents, similar to the organization found in non-mammal vertebrates. At present, we know very little about how this complex multi-oscillator system is integrated.Although there is substantial information available about the SCN, the molecular components, localization and natural role of MASCO in the body are unknown. In fact, it is still debated whether MASCO is a bona fide circadian oscillator rather than a simple hourglass mechanism. This is largely due to the lack of a robust circadian model to study the effects of methamphetamine (MAP) on circadian rhythms. This thesis aims to fill some of these gaps in our understanding of this fascinating major oscillator 3 Using mice, we successfully replicated the published effects of chronic MAP on the circadian rhythms of rats. In fact, the differences such as more robust and clear activity rhythms, more pronounced MAP-induced second components of the rhythm and obvious sex and strain differences make the mice a better model.The results also indicated that MASCO interacts with the SCN in a manner that is strain, sex and dose dependent. Our experiments testing the hourglass explanation showed that the effects of MAP can not be explained by such a mechanism. This suggests that MASCO has circadian properties and is indeed a bona fide circadian clock. We also tried to elucidate the similarities between the molecular components of SCN and MASCO using several circadian mutant mice that were available to us. Although, the results of these experiments are not adequate to propose a list of known circadian genes that are involved in MASCO function, they provide the background for future studies that will determine the differences between the molecular components of SCN and MASCO.Utilization of the mouse strains presented in this thesis will provide an easy to obtain standard model where MASCO can be studied using latest developments in genetics and molecular biology. Identification of the natural role of MASCO in the body and its interactions with other oscillators in the body is of both scientific and clinical significance and will greatly improve our understanding of the circadian system in mammals.4 Acknowledgements I would like to thank Dr.Menaker for his continuous support and outstanding mentoring. I owe whatever I accomplished during my time at UVA to him and could never repay my debt. I a...

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Phase-dependent phase shift of methamphetamine-induced circadian rhythm by haloperidol in SCN-lesioned rats

Cited by 31 publications

References 16 publications

Phase Advance Is an Actimetric Correlate of Antidepressant Response to Sleep Deprivation and Light Therapy in Bipolar Depression

Phase Advance Is an Actimetric Correlate of Antidepressant Response to Sleep Deprivation and Light Therapy in Bipolar Depression

Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse

Effects of Methamphetamine on Circadian Rhythms of Mice

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