“…Consistent with the critical roles of glucuronidation and sulfonation in the first-pass clearance of hesperetin, an array of UDP-glucuronosyltransferase (UGT) enzymes (i.e., UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, and UGT2B15) and multiple sulfotransferase (SULT) enzymes (including SULT1A1, SULT1A3, and SULT2A1) are actively involved in conjugating hesperetin (Brand et al, 2010a). In addition, hesperetin conjugates are found to be the main circulating metabolites in humans and rodents, confirming the importance of conjugative metabolism in hesperetin disposition (Matsumoto et al, 2004;Takumi et al, 2012;Yamamoto et al, 2013).…”