Phase II trial of high-dose melatonin oral gel for the prevention and treatment of oral mucositis in H&amp;N cancer patients undergoing chemoradiation (MUCOMEL).

Lozano, A.; Marruecos, J.; Rubió‐Casadevall, Jordi; Farré, Núria; López‐Pousa, Antonio; Giralt, Jordi; Planas, Isabel; Cirauqui, Beatriz; Lanzuela, M.; Morera, R.; Escribano, A.; Gómez-Millán, Jaime; Toledo, M. D.; Masedo, Gonzalo Vázquez; Cascallar, L.; Grima, P.; Valentí, V.; Tarragó, Cristina; Bosser, R.; Mesı́a, Ricard

doi:10.1200/jco.2018.36.15_suppl.6007

Cited by 9 publications

(9 citation statements)

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“…[13]. Various clinical trials have also confirmed the efficacy of some of these natural products [53,54]. Since experimental findings have shown encouraging radioprotective results for hesperidin, it would be interesting to see how it competes with other radioprotectors.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective Effect of Hesperidin: A Systematic Review

et al. 2019

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Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and www.ClinicalTrials.gov for information about completed or ongoing clinical trials. Results: From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case—control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights.

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Section: Discussionmentioning

confidence: 99%

Radioprotective Effect of Hesperidin: A Systematic Review

et al. 2019

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“…A clinical study by Ben-David et al reported the ability of melatonin to protect against radiodermatitis (which is commonly observed after RT for breast cancer) [59]. As an adjuvant in chemoradiation for head and neck cancer, melatonin administration has been shown to delay the appearance of grade 3 oral mucositis and grade 2 xerostomia, leading to uninterrupted treatment, thereby improving both treatment outcomes and patients’ quality of life [60,61]. Results from these clinical findings are encouraging towards future clinical studies on the efficacy of melatonin for protection against radiotherapy-induced small intestinal damages.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Melatonin Against Radiotherapy-Induced Small Intestinal Oxidative Stress: Biochemical Evaluation

2019

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Background and Objectives: Radiation enteritis is a common side effect after radiotherapy for abdominal and pelvic malignancies. The aim of the present study was to investigate the protective effect of melatonin, known for its free radical scavenging ability, against radiotherapy-induced small intestinal oxidative damage. Materials and Methods: Thirty male Wistar rats were randomly assigned to six groups (5 rats in each) as follows: Group I (control group) rats received neither radiation nor melatonin; group II rats received only 8 Gy single dose of gamma radiation to their abdomen and pelvis regions; group III (administered with only 50 mg/kg melatonin); group IV (administered with only 100 mg/kg melatonin); group V (50 mg/kg melatonin + 8 Gy radiation), group VI (100 mg/kg melatonin + 8 Gy radiation). All rats were sacrificed after 5 days for biochemical assessments of their intestinal tissues. Results: Treatment with melatonin post irradiation significantly reduced malondialdehyde (MDA) levels as well as increased both superoxide dismutase (SOD) and catalase (CAT) activities of the irradiated intestinal tissues. In addition, melatonin administration with different doses pre irradiation led to protection of the tissues. Moreover, the 100 mg/kg dose was more effective compared to 50 mg/kg. Conclusions: The results of our study suggest that melatonin has a potent protective effect against radiotherapy-induced intestinal damage, by decreasing oxidative stress and increasing antioxidant enzymes. We recommend future clinical trials for more insights.

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“…Melatonin possesses antiapoptotic [91], antioxidant [92], anti-inflammatory [93], tumor sensitizing [94], as well as neuroprotective abilities [95]. Clinical studies have shown promising results in its use in radiotherapy for preventing complications such as dermatitis, and oral mucositis [96,97,98].…”

Section: Melatoninmentioning

confidence: 99%

Radiation-Induced Heart Diseases: Protective Effects of Natural Products

Musa

Shabeeb

2019

Medicina

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Cardiovascular diseases (CVDs) account for the majority of deaths worldwide. Radiation-induced heart diseases (RIHD) is one of the side effects following exposure to ionizing radiation (IR). Exposure could be from various forms such as diagnostic imaging, radiotherapy for cancer treatment, as well as nuclear disasters and nuclear accidents. RIHD is mostly observed after radiotherapy for thoracic malignancies, especially left breast cancer. RIHD may affect the supply of blood to heart muscles, leading to an increase in the risk of heart attacks to irradiated persons. Due to its dose-limiting consequence, RIHD has a negative effect on the therapeutic efficacy of radiotherapy. Several methods have been proposed for protection against RIHD. In this paper, we review the use of natural products, which have shown promising results for protection against RIHD.

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Phase II trial of high-dose melatonin oral gel for the prevention and treatment of oral mucositis in H&N cancer patients undergoing chemoradiation (MUCOMEL).

Cited by 9 publications

References 0 publications

Radioprotective Effect of Hesperidin: A Systematic Review

Radioprotective Effect of Hesperidin: A Systematic Review

Protective Effect of Melatonin Against Radiotherapy-Induced Small Intestinal Oxidative Stress: Biochemical Evaluation

Radiation-Induced Heart Diseases: Protective Effects of Natural Products

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