Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation

Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial

“…Several treatment options have been tried for the preventive and therapeutic purpose of OM, but until now none hold the complete success [9]. LLLT has proved some good results in the prevention and treatment of OM induced by anticancer therapy in previous studies that include our previous studies [10][11][12][13][14][15][16][17][18][19][20]. To our knowledge, through an extensive literature search none of the studies have specifically evaluated the effects of LLLT against radiotherapy induced OM in elderly patients, so we did this study.…”

“…Low Level Laser Therapy (LLLT) is one of the physical modalities in photo-medicine which has been used in the prevention and treatment of cancer therapy induced OM in various patient settings. Few researches including our previous research showed positive results in reducing the incidence and severity of OM by using LLLT [10][11][12][13][14][15][16][17][18][19][20]. Many of these studies were done on the pediatric and adult population, but until now none of the studies have specifically evaluated the effects of LLLT in elderly people receiving RT for HNC.…”

Actualités de la prévention et du traitement des mucites orales chez les enfants cancéreux : recommandations pratiques

“…En fait, les auteurs estimeraient que la douleur serait cliniquement plus importante que la présence d'ulcères objectifs dans la cavité orale. Les lésions de la muqueuse peuvent Tableau 1 Grades des mucites orales selon l'échelle de l'Organisation mondiale de la santé (OMS) [17][18][19][20].…”

“…Elle prend en compte les aspects anatomique, fonctionnel et symptomatique de la mucite orale et les classe en degrés de gravité croissante (Tableau 1) [16][17][18][19].…”

“…Elle réduit l'incidence de l'ulcération et de l'érythème [6]. La Société internationale d'oncologie orale limite l'administration de la benzydamine aux patients recevant une dose modérée de radiothérapie [17,24].…”