Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase

Abstract

Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidaseEugenia involucrata DC. (Myrtaceae), popularly known as "cereja-do-Rio-Grande", is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), ethyl acetate (FEA) and butanol (FBu) of leaves were assessed to determine the phenolic chemical composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC 50 = 44.19 µg mL -1 , for FEA) and α-glucosidase (α-Glu) (best result: IC 50 = 31.25 ± 0.15 µg mL -1 , for CHE).The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

“…It is well known that natural products provide abundant and effective small molecule drug targets for the treatment of human diseases [ 58 ]. It is well known that phenolic antioxidants play an important role in avoiding or delaying the onset of major degenerative diseases, such as AD and T2DM [ 59 ]. In our study, we demonstrate that ethanol and water extracts of kınkor ( Ferulago stellata ) have a rich content of small molecules such as chlorogenic acid, rutin, and orientin.…”

Potential of Brazilian berries in developing innovative, healthy, and sustainable food products

“…Work on cherry of Rio Grande demonstrated its effectiveness as an antitumor agent involving a heterogeneous and complex mechanism related to proliferation, oxidative stress and cytoskeletal architecture of tumor cells and has also presented promising activity for the management of diabetes through the inhibitory effect of the enzymes a-glucosidase and acetylcholinesterase (Table 6). 103,160 Pitanga also presented compounds in its composition that are effective in inhibiting a-amylase and extracted nanoparticles from this fruit have already been identied as potential cholesterol reducers. 161,162 a Wet basis.…”

“…Work on cherry of Rio Grande demonstrated its effectiveness as an antitumor agent involving a heterogeneous and complex mechanism related to proliferation, oxidative stress and cytoskeletal architecture of tumor cells and has also presented promising activity for the management of diabetes through the inhibitory effect of the enzymes α-glucosidase and acetylcholinesterase (Table 6). 103,160…”

Development and application on strawberries of edible coatings based on yam and corn starch added with Rio Grande cherry

“…The antioxidant activity presented by the Rio Grande cherry indicates that its use for incorporation into edible films may be feasible, causing this activity to bring about later oxidation of the material that was coated and, consequently, increase its shelf life. In addition, other applications can be indicated due to this characteristic, such as the treatment of pathologies (Cipriani et al, 2022).…”