Phenolic content, acute toxicity of Ajuga iva extracts and assessment of their antioxidant and carbohydrate digestive enzyme inhibitory effects

Fettach, Saad; Mrabti, Hanae Naceiri; Sayah, Karima; Bouyahya, Abdelhakim; Salhi, Najoua; Cherrah, Yahia; Abbes, F.

doi:10.1016/j.sajb.2019.08.010

Cited by 42 publications

(34 citation statements)

References 37 publications

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“…Moreover, our results are in agreement with other studies that found that the aqueous extract of A iva decreased blood glucose levels in diabetic rats compared to the control group 39,40 . Furthermore, our study showed similar results with a recent work 21 that evaluated the antidiabetic effect of A iva extracts on the same enzymes. This activity may be due to the phenolic compounds which have the ability to inhibit the effects of carbohydrate‐hydrolysing enzymes by binding to proteins 41 .…”

Section: Resultssupporting

confidence: 93%

“…This species has been used traditionally in Morocco to treat several illnesses such as diabetes mellitus 17,18 . Biological investigations of A iva extracts showed that this plant exhibited antimicrobial, 19 anti‐parasitic, 20 antidiabetic, 21 anticancer, antioxidant, anti‐hypertension 22 and anti‐inflammatory 23 effects. Moreover, volatile compounds of A iva essential oils (AIEO) have also shown antibacterial, antioxidant, hepatoprotective and antiviral activities against adenovirus type 5, coxsackievirus type B‐3, respiratory syncytial virus type B and herpes simplex virus type 2 1,24‐26 …”

Section: Introductionmentioning

confidence: 99%

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Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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Ajuga iva (A iva) is a medicinal plant used mainly in traditional medicine. This study was aimed to identify the volatile compounds of A iva essential oils (AIEO) at three developmental periods, and to evaluate their pharmacological properties. Chemical volatile compounds were identified by GC/MS analysis. Twenty‐eight volatile components were identified, belonging mainly to oxygenated monoterpenes and hydrocarbons monoterpenes. Carvacrol, octadecane, methyl chavicol were the major volatile components of AIEO at the three phenological stages. FRAP, DPPH and ABTS assays were adopted to estimate the antioxidant effects. AIEO at the vegetative stage exhibited important antioxidant effects with IC50 = 52.43 μg/mL (DPPH), IC50 = 115.22 μg/mL (FRAP), and, IC50 = 143.40 μg/mL (ABTS). The antidiabetic activity was evaluated in vitro by the inhibition of α‐amylase and α‐glucosidase. AIEO at the vegetative stage was the most active as an enzyme inhibitor of α‐amylase (IC50 = 101.727 μg/mL) and α‐glucosidase (IC50 = 86.93 μg/mL). The dermatoprotective effect was investigated by the in vitro inhibition of tyrosinase and elastase activities. AIEO at the vegetative stage showed the lowest IC50 inhibition values against tyrosinase (IC50 = 87.49 μg/mL) and elastase (IC50 = 192.21 μg/mL). Antifungal properties of AIEO were investigated on Trichophyton violaceum, T tonsurans and T mentagrophytes. The three EOs of A iva exhibited important inhibitions of the tested dermatophytes. The findings of this work showed that phenological stages affect significantly the volatile compounds of A iva, and these fluctuations influence mainly the biological properties. Moreover, further investigations concerning in vivo pharmacodynamic and pharmacokinetic investigations as well as clinical trials of these identified compounds could develop antidiabetic, dermatoprotective and anti‐dermatophyte drugs.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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“…Five terpenoids such as ivain I-V were isolated from the diethyl ether extract of the whole plant of A. iva , in addition to 6-desoxyharpagide, 3-8- O -acetylharpagide, 8- O -acetylharpagide, and harpagide. Flavonoids, such as apigenin hexoside-pentoside, apigenin dihexoside, apigenin 7- O -neohesperidoside, naringenin-hexoside, apigenin 7- O -glucoside, and naringenin-7- O -α-L-rhamnopyranosyl, were reported from A. iva [ 13 , 17 ]. Other compounds, including 5-caffeoylquinic acid, apigenin 6,8-di- C -glucoside, 3,5-dicaffeoylquinic acid, and naringin were predominantly found in the infusion of A. iva [ 18 ].…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

“…A. iva possesses hypoglycaemic and hypolipidemic activities [ 19 ]. The bio-evaluation of the alpha-amylase and alpha-glucosidase inhibitory activities of the aqueous and methanolic extracts of the aerial parts of A. iva showed a good inhibition of alpha-amylase, with IC 50 values of 0.210 ± 0.003 and 0.180 ± 0.005 μg/mL, as well as of alpha-glucosidase, with IC 50 values of 0.172 ± 0.012 and 0.130 ± 0.008 μg/mL, respectively [ 17 ].…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

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Diabetes is one of the most dangerous metabolic disorders, with high rates of mortality worldwide. Since ancient times, medicinal plants have been used in traditional medicine to treat many diseases, including diabetes and its related complications. Plants are widely accepted, affordable, and perceived to have minimal adverse side effects. The Lamiaceae family is a potential source of therapeutic agents for the management of metabolic disorders, including diabetes. Hence, this review paper summarizes the antidiabetic use of Lamiaceae species in folk medicine globally. Furthermore, we present the antidiabetic activities and phytochemical constituents of twenty-three (23) Lamiaceae species and the antidiabetic activity of some notable chemical constituents isolated from some of these Lamiaceae species.

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“…javanica is a Chinese traditional medicinal plant and was reported to exert hepatoprotective, anti-inflammatory, immune-modulatory, antioxidant, anticancer, and antiviral properties [10,13,14]. Aerial parts of O. javanica were shown to contain biphenyl derivatives exhibiting anti-inflammatory properties by inhibiting cyclooxygenase-2 (COX-2), with 1-(6 -hydroxy-3 -prenyl-phenyl)-10,11-dimethyl-2H-chromen-2-ol possessing the highest activity (IC 50 22.18 µM), comparable to celecoxib used as a reference COX-2 inhibitor (IC 50 18.08 µM) [15]. Recently, O. javanica was reported to display photoprotective activity against UVB-induced collagen disruption and inflammation, which warrants possible application for the treatment of photodamaged skin [16].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Biological Activities of the Extracts from Two Oenanthe Species (O. aquatica and O. silaifolia)

et al. 2021

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This study presents the evaluation of biological activities and chemical profiling of Oenanthe aquatica (L.) Poir. and Oenanthe silaifolia M. Bieb. The phytochemical profile, antioxidant, enzyme inhibitory, cytotoxic and antiviral activities of the methanolic and aqueous extracts were investigated. The aqueous extract of O. aquatica possessing the highest content of phenolics (60.85 mg gallic acid equivalent/g extract), also exhibited the strongest radical scavenging potential against 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (79.46 and 148.66 mg Trolox equivalent/g extract, respectively), the highest reducing ability (207.59 and 107.27 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant activity, respectively), metal chelating potential (33.91 mg ethylenediaminetetraacetic acid equivalent/g extract) and total antioxidant ability (1.60 mmol Trolox equivalent/g extract). Liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (LC-ESI-QTOF-MS/MS) permitted tentative identification of compounds from simple organic acids, phenolic acids, coumarins, flavonoids and their glycosides in O. aquatica and O. silaifolia extracts. The methanolic extract of O. aquatica substantially depressed acetylcholinesterase (3.67 mg galantamine equivalent/g extract), tyrosinase (126.66 mg kojic acid equivalent/g extract), and α-amylase (0.83 mmol acarbose equivalent/g extract) enzymes. The methanolic extract of O. silaifolia showed highest enzymatic inhibitory property against butyrylcholinesterase, and its aqueous extract depressed α-glucosidase activity (0.26 mmol acarbose equivalent/g extract). All tested extracts exerted selective toxicity towards cancer cell lines, and the highest anticancer potential was found for O. aquatica aqueous extract on FaDu and HeLa cells with CC50 of 57.36 and 47.16 µg/mL, respectively. Significant antiviral activity against HSV-1 (HHV-1) was found for both aqueous extracts in concentrations of 1000 µg/mL, which inhibited the HSV-1 cytopathic effect (CPE) in virus infected VERO cells and reduced the virus infective titer by more than 3 log (logCCID50/mL). This study has produced critical scientific data on O. aquatica and O. silaifolia, which are potential contenders for the development of novel phyto-pharmaceuticals.

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Phenolic content, acute toxicity of Ajuga iva extracts and assessment of their antioxidant and carbohydrate digestive enzyme inhibitory effects

Cited by 42 publications

References 37 publications

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Phytochemical Profile and Biological Activities of the Extracts from Two Oenanthe Species (O. aquatica and O. silaifolia)

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