Phenolic rich extracts from cowpea sprouts decrease cell proliferation and enhance 5-fluorouracil effect in human colorectal cancer cell lines

Teixeira-Guedes, Catarina; Oppolzer, David; Barros, Ana; Pereira‐Wilson, Cristina

doi:10.1016/j.jff.2019.103452

Cited by 28 publications

(16 citation statements)

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“…It is associated with the presence of flavonoids, accumulating mostly in seed coat [ 45 , 49 ]. Anticancer activity in asparagus bean may be expressed as the protection of DNA from injuries and suppression of cancer cell proliferation [ 4 , 50 ]. It was noticed in research studies, when the processes undergoing in the intestines were simulated, that different PC fractions, including catechins, were exposed to various degrees of degradation and absorption, but still retained their bioactivity [ 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was noticed in research studies, when the processes undergoing in the intestines were simulated, that different PC fractions, including catechins, were exposed to various degrees of degradation and absorption, but still retained their bioactivity [ 51 , 52 ]. The content and composition of PC in cowpeas as well as their activity change when seeds are soaked, germinated or undergo culinary processing [ 35 , 36 , 50 ]. The issue of PC activity in a human organism has been actively discussed.…”

Section: Resultsmentioning

confidence: 99%

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Composition of Primary and Secondary Metabolite Compounds in Seeds and Pods of Asparagus Bean (Vigna unguiculata (L.) Walp.) from China

et al. 2020

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Asparagus bean immature pods and seeds are popular as food products for healthy and functional nutrition. Gas chromatography with mass spectrometry was used to compare metabolomic profiles of seeds and pods yielded by old Chinese landraces and the modern cultivars ‘Yunanskaya’ and ‘Sibirskiy razmer’. About 120 compounds were identified. The content of a majority among groups of compounds was higher in pods than in seeds. The amount of free amino acids in pods was 47 times higher, polyols and phytosterols 5 times higher, phenolics 4 times higher, and organic acids and saponins 3 times higher than in seeds. Differences were found in the relative content of compounds. Among phenolic compounds, the dominant one for seeds was protocatechuic acid, and for pods 4-hydroxycinnamic acid. Only polyols were identified in seeds, but pods additionally contained ethanolamine, phytol, and phytosphingosine. The ratio for nonsaturated/saturated fatty acids was 2.2 in seeds and 1.4 in pods. Seeds contained more stigmasterol, and pods more β-sitosterol. Aglycones of saponins were identified: cycloartenol in seeds, α- and β-amyrins in pods. Oligosaccharides dominated in both seeds and pods. Landraces manifested higher protein content in pods, while modern cultivars had pods with higher contents of organic acids, polyols, monosaccharides, and fatty acids. The results obtained confirm the high nutritional value of asparagus bean seeds and pods, and the prospects of their use in various diets.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Composition of Primary and Secondary Metabolite Compounds in Seeds and Pods of Asparagus Bean (Vigna unguiculata (L.) Walp.) from China

et al. 2020

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“…Antioxidants possess great potential as drugs suitable for the treatment of various diseases related to oxidative stress. In particular, the use of compounds containing phenol structural moiety in the treatment of Alzheimer's disease [32][33][34][35][36], Parkinson´s disease [37][38][39], Huntington´s disease [40,41], and cancer [42][43][44][45] have been extensively studied in the last two years. Their structural diversity provides many possibilities for the design and synthesis of new, highly effective agents.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

et al. 2020

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A series of 1,3,5-triazine analogues, incorporating aminobenzene sulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step-by-step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and EC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest concentration 1 × 10−4 M, the %inhibition activity values at 0 min were comparable with both standards at least for 10 compounds. After 60 min, compounds 5, 6, 13, and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with the standards (Trolox = 41.49%; ASA = 31.07%). Values of EC50 at 60 min (17.16–27.78 μM) were 5 times lower for compounds 5, 6, 13, and 25 than EC50 of both standards (trolox = 178.33 μM; ASA = 147.47 μM). Values of EC50 correlated with %inhibition activity. Based on these results, the presented 1,3,5-triazine analogues have a high potential in the treatment of illnesses caused or related to oxidative stress.

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“…Kadar total senyawa fenolik sereal kecambah kacang tunggak signifikan lebih tinggi daripada sereal kacang tunggak (Tabel 5). Perkecambahan dapat meningkatkan senyawa fenolik pada kacang tunggak putih (Khang et al, 2016) maupun kacang tunggak (Teixeira-Guedes et al, 2019). Menurut Tang et al (2014), proses perkecambahan mengaktifkan enzim-enzim biosintesis, sehingga metabolit sekunder akan terakumulasi.…”

Section: Potensi Antioksidan Sereal Kecambah Kacang Tunggakunclassified

PENGEMBANGAN TEPUNG KECAMBAH KACANG TUNGGAK (Vigna unguiculata) SEBAGAI SEREAL FUNGSIONAL KAYA SERAT PANGAN DAN BERPOTENSI ANTIOKSIDAN

Ariviani

Sholihin

Nastiti

2021

J. Teknol. Hasil. Pertanian

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<p>The average consumption of dietary fiber in Indonesian is still below the recommended daily intake. Low dietary fiber intake has an impact on the development of degenerative diseases and metabolic syndrome. One of the risk factors for the occurrence of the disease is oxidative stress. The most effective strategy to overcome oxidative stress is through dietary antioxidants intake. Cowpea is proven to be rich in bioactive compounds such as flavonoids, dietary fiber as well as antioxidants, and these compounds have been successfully increased by germination. This study aims to develop cowpea sprouts flour as a functional cereal high in dietary fiber and antioxidants. The cereal was prepared by the best formula based on two steps of sensory analysis. The first one, the sensory analysis conducted to select the formula based on the best sensory quality of the cereal made by the various proportions of cowpea flour (%b/b) (80, 85, 90, 95, 100). The selected formula was further used to prepare the cereal with different flavoring agents (5% b/b) (ginger, cinnamon, and ginger-cinnamon) to find the best formula based on the preference level. The cereals were further analyzed to determine the sensory quality compared to the commercial cereal, the dietary fiber content which includes the total, soluble, and insoluble dietary fibers, as well as the antioxidant potential with the total phenolic content (TPC) evaluation. Formula with 80%(b/b) cowpea flour and 5% (b/b) ginger as flavoring agents produce cereal with the highest preference level and stated as the best formula. The cowpea sprouts cereal exhibited a significantly higher quality of aroma, texture, and overall than the commercial ones. The cereal also showed the highest levels of total, soluble and insoluble dietary fiber as well as the TPC. These results have significant implications on the development of functional cereal using locally legumes sprouts flour.</p>

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Phenolic rich extracts from cowpea sprouts decrease cell proliferation and enhance 5-fluorouracil effect in human colorectal cancer cell lines

Cited by 28 publications

References 28 publications

Composition of Primary and Secondary Metabolite Compounds in Seeds and Pods of Asparagus Bean (Vigna unguiculata (L.) Walp.) from China

Composition of Primary and Secondary Metabolite Compounds in Seeds and Pods of Asparagus Bean (Vigna unguiculata (L.) Walp.) from China

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

PENGEMBANGAN TEPUNG KECAMBAH KACANG TUNGGAK (Vigna unguiculata) SEBAGAI SEREAL FUNGSIONAL KAYA SERAT PANGAN DAN BERPOTENSI ANTIOKSIDAN

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