Phenotypic deconstruction reveals involvement of manganese transporter<i>malvolio</i>in honey bee division of labor

Ben‐Shahar, Yehuda; Dudek, Nichole L.; Robinson, Gene E.

doi:10.1242/jeb.01151

Cited by 109 publications

(123 citation statements)

References 31 publications

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“…In our experiment, 1-day-old workers had weak expression levels of the Amobp5 and Acobp5 genes; this result is consistent with reports that the maturation of the olfactory neuron function begins 2 days before emergence (Masson and Arnold, 1984). When bees emerge, 1-week-old workers assume cleaning behaviors in their colony (Ben-Shahar et al, 2004;Leoncini et al, 2004;Whitfield et al, 2006). After about 1 week, bees begin to perform new roles, such as nursing, storing, and processing food (e.g., turning nectar into honey) (Trhlin and Rajchard, 2011).…”

Section: Discussionsupporting

confidence: 92%

Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana

Zhao¹,

Zeng

Liang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Apis mellifera ligustica and A. cerana cerana exhibit differences in olfactory sensitivity to odors from nectariferous plants and diseased broods. It is presumed that the differences in odorant-binding proteins (OBPs) between these 2 species contribute to their olfactory sensitivity. We compared the sequences, temporal expression pattern, and binding properties of the 2 OBP-encoding genes. We cloned the Amobp5 and Acobp5 genes. Among the ligands tested, phenethyl acetate was the most variable, with AcOBP5 showing high affinity and AmOBP5 having no apparent affinity for this ligand. While AmOBP5 had high affinity to both benzyl alcohol and 2-phenylethanol, the binding affinity of AcOBP5 to these compounds was moderate. However, the fluorescence intensity of these compounds was not decreased below 50%; thus, the dissociation Study of the obp5 gene in Apis mellifera and Apis cerana constants could not be calculated. The Amobp5 gene showed significantly higher expression in 10-and 15-day-old workers than in other stages, while the Acobp5 gene had the highest expression in 30-day-old workers. Both the Amobp5 and Acobp5 genes had the lowest expression level in 1-day-old workers. These results suggest that the binding properties and temporal expression patterns of the obp5 genes in A. mellifera and A. cerana play a critical role in the olfactory sensitivity of workers.

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Section: Discussionsupporting

confidence: 92%

Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana

Zhao¹,

Zeng

Liang

et al. 2015

Genet. Mol. Res.

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“…This gene also mediates behavioral maturation in honey bees and, as its name implies, is elevated when individuals transition from nursing to foraging (Ben-Shahar et al, 2003). Similarly, increases in the gene malvolio (mvl), a manganese transporter initially described in Drosophila mutants with taste deficiencies (Rodrigues et al, 1995), and NPF are also associated with behavioral maturation to foraging in honey bees (Ben-Shahar et al, 2004). Interestingly, homologs of the NPY pathway also mediate transitions from solitary to social (grouping) behavior in Caenorhabditis elegans (De Bono and Bargmann, 1998) and Drosophila larvae (Wu et al, 2003), suggesting that the role of NPY/NPF in the mediation of social behaviors may be particularly ancient and well conserved across animals.…”

Section: Modification Of Feeding Circuits In the Evolution Of Eusociamentioning

confidence: 98%

Modification of feeding circuits in the evolution of social behavior

Fischer

O’Connell

2017

Journal of Experimental Biology

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Adaptive trade-offs between foraging and social behavior intuitively explain many aspects of individual decision-making. Given the intimate connection between social behavior and feeding/foraging at the behavioral level, we propose that social behaviors are linked to foraging on a mechanistic level, and that modifications of feeding circuits are crucial in the evolution of complex social behaviors. In this Review, we first highlight the overlap between mechanisms underlying foraging and parental care and then expand this argument to consider the manipulation of feeding-related pathways in the evolution of other complex social behaviors. We include examples from diverse taxa to highlight that the independent evolution of complex social behaviors is a variation on the theme of feeding circuit modification.

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“…Evidence also showed that this taste behavior holds true for honeybees, Apis mellifera. An increase in brain mvl expression leads to an elevation in Mn transport, sucrose responsiveness and, ultimately, division of labor within the colonies (Ben-Shahar et al, 2004).…”

Section: Possible Dmt1 Transport Of Mn In Other Systemsmentioning

confidence: 99%

Manganese transport in eukaryotes: The role of DMT1

2008

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Manganese (Mn) is a transition metal that is essential for normal cell growth and development, but is toxic at high concentrations. While Mn deficiency is uncommon in humans, Mn toxicity is known to be readily prevalent due to occupational overexposure in miners, smelters and possibly welders. Excessive exposure to Mn can cause Parkinson's disease-like syndrome; patients typically exhibit extrapyramidal symptoms that include tremor, rigidity and hypokinesia (Calne et al., 1994;Dobson et al., 2004).Mn-induced motor neuron diseases have been the subjects of numerous studies; however, this review is not intended to discuss its neurotoxic potential or its role in the etiology of motor neuron disorders. Rather, it will focus on Mn uptake and transport via the orthologues of the divalent metal transporter (DMT1) and its possible implications to Mn toxicity in various categories of eukaryotic systems, such as in vitro cell lines, in vivo rodents, the fruitfly, Drosophila melanogaster, the honeybee, Apis mellifera L., the nematode, Caenorhabditis elegans, and the baker's yeast, Saccharomyces cerevisiae. Keywords DMT1; Manganese; NRAMP-2; Transport ManganeseMn is one of the most abundant naturally occurring elements in the earth's crust; it does not occur naturally in a pure state. Oxides, carbonates and silicates are the most important Mncontaining minerals (Post, 1999). Depending on its oxidation state, Mn is utilized in countless industrial processes, such as the production of dry cell batteries, steel (Post, 1999; Saric, 1986), fuel oil additives and antiknock agents (Pfeifer et al., 2004;Ressler et al., 1999;Rollin et al., 2005). *Corresponding Author: Michael Aschner, PhD, 2215-B Garland Avenue, 11425 MRB IV, Vanderbilt University Medical Center, Nashville, michael.aschner@vanderbilt.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeurotoxicology. Author manuscript; available in PMC 2009 July 1. Published in final edited form as:Neurotoxicology. 2008 July ; 29(4): 569-576. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptThe major source of Mn in humans is through dietary ingestion. Approximately 3-5% of ingested Mn is absorbed across the intestinal wall, and the remainder is excreted in feces, representing tight homeostatic control over Mn absorption. Mn toxicity from dietary intake is rare; its uptake is tightly regulated, and any excess of ingested Mn is readily excreted via the bile. In contrast, both pulmonary uptake and particulate transport via the olfactory bulb (Saric, 1986;Aschner et al., 1991...

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Phenotypic deconstruction reveals involvement of manganese transportermalvolioin honey bee division of labor

Cited by 109 publications

References 31 publications

Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana

Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana

Modification of feeding circuits in the evolution of social behavior

Manganese transport in eukaryotes: The role of DMT1

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